Data_Sheet_2_SNP-Based Genotyping Provides Insight Into the West Asian Origin of Russian Local Goats.PDF by Tatiana E. Deniskova (5527175)

“…In addition, we addressed genetic relationships between local and global goat populations obtained from the AdaptMap project. Russian goats showed a high level of genetic diversity. Although a decrease in historical effective population sizes was revealed, the recent effective population sizes estimated for three generations ago were larger than 100 in all studied populations. …”

Schematic illustration of the variable-ranking process for the derivation cohort. by Johan Nilsson (364438)

“…Step II: variable-ranking using the trained survival model from step I. …”

Geographic Analysis of Urologist Density and Prostate Cancer Mortality in the United States by Nengliang Yao (760915)

“…</p><p>Findings</p><p>The ordinary least squares (OLS) regression found that, on average, increasing urologist density by 1 urologist per 100,000 people resulted in an expected decrease in prostate cancer mortality of -0.499 deaths per 100,000 men (95% CI -0.709 to -0.289, p-value < 0.001), or a 1.5% decrease. …”

Viral ORF57 inhibits eIF2α phosphorylation through down-regulation of PKR pathway. by Nishi R. Sharma (4543936)

“…The relative levels of p-eIF2α (Ser 51), phospho-PKR (Thr 451), total eIF2α, and total PKR in each sample were determined by Western blot with the corresponding antibodies and are plotted in bar graphs (C), with the expression level in the sample without ORF57 being set to 100% after normalized to GAPDH which served as a loading control. …”

miR-143 binding to the 3′ UTR of PTGS2 mRNA. by Sun Young Kim (91779)

“…In AECs, there is a 58.5% of decrease in luciferase activity following transfection with miR-143 mimic but transfection of miR-143 hairpin inhibitor does not alter luciferase activity. …”

GBE enhanced oxygen consumption of isolated mitochondria and led to an up-regulation of mitochondrial DNA. by Virginie Rhein (243241)

“…<p><b>A</b>) Two-way ANOVA revealed a significant Aβ-induced decrease of the total cellular respiration in isolated mitochondria from APP cells compared to that of control cells (group effect: control vs. …”

Acute HIV-1 gp120 induces calcium (Ca²⁺) flux and dephosphorylation of Kv2.1 in hippocampal neurons. by Andrew J. Shepherd (462677)

“…Densitometric analysis of Kv2.1 immunoreactive band intensities at molecular weight range of ~90 to ~150 kDa (see methods for details), showing phospho-Kv2.1 with peak intensity at ~130 kDa and dephospho-Kv2.1 with peak intensity at ~100 kDa. Data are presented as mean (n = 4-5 for each group).…”

Age-related increase of neuronal stress in forebrain-specific <i>Xpg</i> knockout mice. by Sander Barnhoorn (641837)

“…(D) Representative images of Mac2 immunostained sagittal brain sections of 26- and 52-week old <i>Emx1-Xpg</i> and <i>wt</i> mice showing Mac2-positive microgliosis and a progressive decrease in size of the cerebral cortex and hippocampus of <i>Emx1-Xpg</i> mice. …”

CCDC66-depleted cells exhibit abnormal ciliary signaling and transport. by Jovana Deretic (13113617)

“…(<i>p</i> value of Welch’s <i>t</i> test, *<i>p</i> = 0.0183). Mean ciliary fluorescence density of SMO in CCDC66 depletion is decreased to 0.33-fold of the control mean. …”

<i>vang-1(tm1422)</i> life span modulation depends on Insulin/IGF-1-like signaling and leads to higher DAF-16 activity. by Sebastian J. Honnen (183696)

“…In contrast, depletion of DAF-16 by RNAi in <i>tm1422</i> (rose spotted line) and WT (purple solid line) causes a decrease of mean life span to <b>12±0.3 d</b> (n = 247*) and <b>11.9±0.2 d</b> (n = 142*), respectively (p<0.96**). …”

Evidence for Substrate Preorganization in the Peptidylglycine α-Amidating Monooxygenase Reaction Describing the Contribution of Ground State Structure to Hydrogen Tunneling by Neil R. McIntyre (2249155)

“…The first step, the copper-, ascorbate-, and O₂-dependent stereospecific hydroxylation at the α-carbon of the C-terminal glycine, is catalyzed by peptidylglycine α-hydroxylating monooxygenase (PHM). …”

Evidence for Substrate Preorganization in the Peptidylglycine α-Amidating Monooxygenase Reaction Describing the Contribution of Ground State Structure to Hydrogen Tunneling by Neil R. McIntyre (2249155)

“…The first step, the copper-, ascorbate-, and O₂-dependent stereospecific hydroxylation at the α-carbon of the C-terminal glycine, is catalyzed by peptidylglycine α-hydroxylating monooxygenase (PHM). …”

Evidence for Substrate Preorganization in the Peptidylglycine α-Amidating Monooxygenase Reaction Describing the Contribution of Ground State Structure to Hydrogen Tunneling by Neil R. McIntyre (2249155)

“…The first step, the copper-, ascorbate-, and O₂-dependent stereospecific hydroxylation at the α-carbon of the C-terminal glycine, is catalyzed by peptidylglycine α-hydroxylating monooxygenase (PHM). …”

Feijoa F3 activates autophagy and inhibits NF-κB activity in HCT15 cells. by Noha Ahmed Nasef (760610)

“…A percentage of greater than 100 shows increased inflammatory response in the presence of the ligand when compared to media (no treatment); and a percentage of less than one suggests a decrease in the inflammatory response in the presence of the ligand when compared to media (no treatment) meaning that a condition has inhibited NF-κB signaling. …”

Uniform downscaling of postsynaptic AMPA receptors across the dendritic tree in primary hippocampal cultures. by Mathieu Letellier (6803699)

“…(B) Representative EPSC trace evoked by a pair of brief depolarizations (+100 mV, 50-ms interval) of the presynaptic neuron. …”

<i>klf4</i> is required for the maintenance of the <i>egc</i>^<i>+</i><i>/meg-1</i>^<i>+</i><i>/zfp-1-1</i>^<i>+</i> TRL. by Lu Zhao (296389)

“…(F) FISH depicting a modest decrease in <i>tsp-2</i>⁺ cell number following <i>klf4</i> RNAi. …”

Effect of hypotonic stress and elevated K⁺ on the ECS diffusion parameters in α-syn +/+ and α-syn −/− mice <i>in vitro</i>. by Lesia Dmytrenko (431060)

“…The mean values of the maximum change during application correspond to the time-point of the maximum decrease of α (i.e., the 25^th min in H-50 and H-100 and the 30^th min in 10 mM K⁺); the values for washout correspond to the data point at the 90^th min. …”

Image5_The effect of ginger extract on cisplatin-induced acute anorexia in rats.TIFF by Hyeonah Kim (17359114)

“…Among these, acute anorexia is one of the most severe secondary effects. In this study, a single oral administration of 100 or 500 mg/kg ginger extract (GE) significantly alleviated the cisplatin-induced decrease in food intake in rats. …”

Image1_The effect of ginger extract on cisplatin-induced acute anorexia in rats.TIF by Hyeonah Kim (17359114)

“…Among these, acute anorexia is one of the most severe secondary effects. In this study, a single oral administration of 100 or 500 mg/kg ginger extract (GE) significantly alleviated the cisplatin-induced decrease in food intake in rats. …”

Image2_The effect of ginger extract on cisplatin-induced acute anorexia in rats.TIF by Hyeonah Kim (17359114)

“…Among these, acute anorexia is one of the most severe secondary effects. In this study, a single oral administration of 100 or 500 mg/kg ginger extract (GE) significantly alleviated the cisplatin-induced decrease in food intake in rats. …”