Image7_The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis.JPEG by Paolo Comeglio (14195007)

“…Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human K_D = 25 nM; rabbit K_D = 12 nM) and high oral bioavailability in rabbits and man. …”

Image5_The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis.JPEG by Paolo Comeglio (14195007)

“…Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human K_D = 25 nM; rabbit K_D = 12 nM) and high oral bioavailability in rabbits and man. …”

Table3_The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis.docx by Paolo Comeglio (14195007)

“…Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human K_D = 25 nM; rabbit K_D = 12 nM) and high oral bioavailability in rabbits and man. …”

Table1_The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis.docx by Paolo Comeglio (14195007)

“…Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human K_D = 25 nM; rabbit K_D = 12 nM) and high oral bioavailability in rabbits and man. …”

Increase in conjugated linoleic acid content and improvement in microbial and physicochemical properties of a novel kefir stored at refrigerated temperature using complementary pro... by Hamid POURBABA (10465398)

“…A 4-fold increase in the acetic acid value (0.592 g/100 mL) was observed in kefirs supplemented with B. lactis BB-12 along with L. acidophilus LA-5 and L. paracasei 431 (G12). …”

Mapping maternal mortality rate via spatial zero-inflated models for count data: A case study of facility-based maternal deaths from Mozambique by Osvaldo Loquiha (300896)

“…<div><p>Maternal mortality remains very high in Mozambique, with estimates from 2015 showing a maternal mortality ratio of 489 deaths per 100,000 live births, even though the rates tend to decrease since 1990. …”

Image_1_The Association Between Alveolar Dead Space Fraction and Mortality in Pediatric Acute Respiratory Distress Syndrome: A Prospective Cohort Study.TIF by Sheow Boon Oh (12157812)

“…This study aims to characterize AVDSF in patients with pediatric ARDS (PARDS), to determine its association with clinical outcomes and examine the validity of a previously studied cutoff (AVDSF > 0.25).</p>Methods<p>This was a prospective cohort study performed in the setting of a lung protective mechanical ventilation protocol. …”

Image_5_The Association Between Alveolar Dead Space Fraction and Mortality in Pediatric Acute Respiratory Distress Syndrome: A Prospective Cohort Study.TIF by Sheow Boon Oh (12157812)

“…This study aims to characterize AVDSF in patients with pediatric ARDS (PARDS), to determine its association with clinical outcomes and examine the validity of a previously studied cutoff (AVDSF > 0.25).</p>Methods<p>This was a prospective cohort study performed in the setting of a lung protective mechanical ventilation protocol. …”

Image_2_The Association Between Alveolar Dead Space Fraction and Mortality in Pediatric Acute Respiratory Distress Syndrome: A Prospective Cohort Study.TIF by Sheow Boon Oh (12157812)

“…This study aims to characterize AVDSF in patients with pediatric ARDS (PARDS), to determine its association with clinical outcomes and examine the validity of a previously studied cutoff (AVDSF > 0.25).</p>Methods<p>This was a prospective cohort study performed in the setting of a lung protective mechanical ventilation protocol. …”

Image_4_The Association Between Alveolar Dead Space Fraction and Mortality in Pediatric Acute Respiratory Distress Syndrome: A Prospective Cohort Study.TIF by Sheow Boon Oh (12157812)

“…This study aims to characterize AVDSF in patients with pediatric ARDS (PARDS), to determine its association with clinical outcomes and examine the validity of a previously studied cutoff (AVDSF > 0.25).</p>Methods<p>This was a prospective cohort study performed in the setting of a lung protective mechanical ventilation protocol. …”

Image_3_The Association Between Alveolar Dead Space Fraction and Mortality in Pediatric Acute Respiratory Distress Syndrome: A Prospective Cohort Study.TIF by Sheow Boon Oh (12157812)

“…This study aims to characterize AVDSF in patients with pediatric ARDS (PARDS), to determine its association with clinical outcomes and examine the validity of a previously studied cutoff (AVDSF > 0.25).</p>Methods<p>This was a prospective cohort study performed in the setting of a lung protective mechanical ventilation protocol. …”

Flow cytometric analysis of putative cancer stem cell pools in control and Syndecan-1-silenced MDA-MB-231 breast cancer cells. by Sherif A. Ibrahim (504852)

“…Syndecan-1 siRNA knockdown results in a significant decrease of the SP and ALDH activity. …”

Additional file 3 of C. elegans as a test system to study relevant compounds that contribute to the specific health-related effects of different cannabis varieties by Monique van Es-Remers (13895294)

“…In this assay C. elegans was exposed to different concentrations (5, 50 and 100 μg/mL) of the Non-Polar Fractions both in carboxylated (NPFdec) and non-decarboxylated (NPF) form. …”

Data_Sheet_1_Projecting trends in the disease burden of adult edentulism in China between 2020 and 2030: a systematic study based on the global burden of disease.docx by Xiaofeng Qin (10721592)

“…Males experienced a higher increase than females. However, the standardized rates decreased over the same period. …”

Hypoxia Activates a Ca²⁺-Permeable Cation Conductance Sensitive to Carbon Monoxide and to GsMTx-4 in Human and Mouse Sickle Erythrocytes by David H. Vandorpe (254705)

“…</p><h3>Methodology/Principal Findings</h3><p>We now show by cell-attached and nystatin-permeabilized patch clamp recording from sickle erythrocytes of mouse and human that deoxygenation reversibly activates a Ca²⁺- and cation-permeable conductance sensitive to inhibition by <em>Grammastola spatulata</em> mechanotoxin-4 (GsMTx-4; 1 µM), dipyridamole (100 µM), DIDS (100 µM), and carbon monoxide (25 ppm pretreatment). …”

File S1 - Impact of Glucocorticoid Receptor Density on Ligand-Independent Dimerization, Cooperative Ligand-Binding and Basal Priming of Transactivation: A Cell Culture Model by Steven Robertson (414616)

“…Exposure times of 1500 ms at 100% light intensity were used. F-don values reflect the CFP signal after 30 minutes of DEX stimulation measured in a region of interest in the nucleus of each individual cell. …”

Effect of a roadblock on ParB2-mediated stimulation of <i>oriII</i> activity in <b><i>E. coli</i></b>. by Tatiana Venkova-Canova (424756)

“…<p>Two <i>oriII</i> plasmids, pTVC20 and pBJH218, isogenic except for about 100 bp extra sequences carrying an array of five P1 RepA binding sites (iterons) in the latter, were used to transform BR8706 (<i>recA</i> minus) cells without (#1, #2) and with (#3, #4) an integrated λ prophage (λDKC311). …”

Data_Sheet_1_Will Multidisciplinary Collaboration Reduce the Disability Rate of Diabetic Foot (2009–2019)?—A Study Based on the Perspective of Organizational Reform.PDF by Mengchi Hou (11537440)

“…After the multidisciplinary collaboration, the rate of above-knee amputation is reduced by 3.63%, the disability score per 100 diabetic foot patients decreases by 6.12, the average length of stay decreases significantly, and the cost of hospitalization shows an increasing trend.…”

Table_1_Short-Term Physical Inactivity Induces Endothelial Dysfunction.docx by Kelly A. Bowden Davies (7247510)

“…Following 14 days of step-reduction, endothelial function was reduced by a 1.8% (0.4, 3.3; P = 0.01) decrease in FMD. …”

Pharmacodynamic Consequences of Administration of VLA-4 Antagonist CDP323 to Multiple Sclerosis Subjects: A Randomized, Double-Blind Phase 1/2 Study by Christian Wolf (385271)

“…<div><p>Background</p><p>Lymphocyte inhibition by antagonism of α4 integrins is a validated therapeutic approach for relapsing multiple sclerosis (RMS).…”