Table 1_Burden of esophageal cancer in global, regional and national regions from 1990 to 2021 and its projection until 2050: results from the GBD study 2021.docx by Chengcheng Zhang (725743)

“…</p>Results<p>In 2021, there were 576,529 new esophageal cancer cases, with an age-standardized incidence rate (ASIR) of 6.65 per 100,000, reflecting a 24.87% decrease since 1990. …”

Western blot assay was performed to assess the effect of MDR1 siRNA loaded nanoparticles on expression of P-gp. by Michiro Susa (248432)

“…<p>The expression of P-gp was significantly decreased after application of 30 nM MDR1 siRNA loaded nanoparticles for KHOS_R2 (<i>A</i>) and 100 nM MDR1 siRNA loaded nanoparticles for U-2OS_R2 (<i>B</i>). …”

Data Sheet 1_Comparison of trend analysis of varicella zoster disease burden between China and the world 1990–2021 and disease burden forecast 2030.csv by Zhichun Chang (18594517)

“…The age-standardized disability-adjusted life year rate (ASDR) in China decreased significantly, from 17.68/100,000 to 4.66/100,000, while the global ASDR decreased from 19.28/100,000 to 12.31/100,000. …”

Activation of p65, and not p52, is critical to the apoptotic resistance in U2OS cells. by Brian K. Bednarski (259893)

“…Western blot for p65 confirmed significant knockdown. Evaluation of p100 levels revealed a modest decrease of p100 in the cells lacking p65 and complete knockdown in the cells treated with sip100. …”

Gal-3 is upregulated in hypoxia in NG97ht cells. by Rafael Yamashita Ikemori (698128)

“…In the treatment of the protein extracts with AP, there was a decrease in isoforms 2 and 3 compared to control samples mainly in cells exposed to normoxia. …”

An effective “three-in-one” screening assay for testing drug and nanoparticle toxicity in human endothelial cells by Marcela Filipova (165639)

“…Our results indicated that all the tested NP types induced decreases in cell viability after 24 hours at a concentration of 100 μg/ml. …”

Table 1_Global, regional, national epidemiology and trends of Parkinson’s disease from 1990 to 2021: findings from the Global Burden of Disease Study 2021.docx by Yuanrong Luo (20539082)

“…Age-standardized rates of incidence, prevalence, and DALYs increased to 15.63/100,000, 138.63/100,000, and 89.59/100,000. The burden of Parkinson’s disease were higher in males than in females, and showed an increase and then a slight decrease with age. …”

Potential mechanisms. by Iwan Zimmermann (117942)

“…Channel gating (described by the efficacy equilibrium constant <i>E</i>) is impaired when the channel is bound to divalent ions (yellow circles, <i>E</i>_Ca²⁺). The decrease in agonist efficacy is likely to be due to a change in the rate of opening, as shown by the size of the arrows in the last step of the reaction. …”

The effect of HuR expression levels on Epi-induced ROS production in SW620 cells. by Guan-Liang Lin (2423170)

“…The relative ROS percentage was calculated by setting the mean fluorescence intensity of siC group as 100%. …”

Pharmacokinetics and pharmacodynamics after treatment of DIO-mice with HI, X10 and IGF-1 by sc injection. by Henning Hvid (486358)

“…<p>A: Plasma concentrations measured in mice treated with HI, X10 or IGF-1. …”

The effects of Hh protein and agonist on vertebrate Smo and Ptc proteins by Maria Frank-Kamenetsky (26382)

“…Blots in (b) and (c) were reprobed with anti-tubulin antibody as a sample loading control. Anti-HA protein blot of cell extracts, fractionated by SDS-polyacrylamide gel electrophoresis, from cells treated with decreasing concentrations of Hh protein (lane 1, 100 nM; lane 2, 50 nM; lane 3, 25 nM; lane 4, 12.5 nM; lane 5, 6.25 nM; lane 6, 3.12 nM), or with vehicle (lane 7), or with increasing concentrations of Hh-Ag 1.2 (agonist; lane 8, 15 nM; lane 9, 31.25 nM; lane 10, 62.5 nM; lane 11, 250 nM; lane 12, 500 nM; lane 13, 1 μM) for 22 hours. …”

shRNA-mediated knockdown of <i>Tsc2</i> expression in 3T3-L1 preadipocytes leads to enhanced mTORC1-dependent adipocyte differentiation. by Hui H. Zhang (262186)

“…<p>(A) 3T3-L1 preadipocytes with stable shRNA-mediated knockdown of <i>Tsc2</i> expression display elevated basal mTORC1 signaling and attenuation of insulin-stimulated Akt phosphorylation. 3T3-L1 preadipocytes stably expressing shRNAs targeting <i>Tsc2</i> (shTsc2), or firefly luciferase (shLuc) as a control, were serum-starved for 16 h and, where indicated, were pretreated with rapamycin for 15 min prior to stimulation with 100-nM insulin for 15 min. …”

Data from: Viviparity does not affect the numbers and sizes of reptile offspring by Shai Meiri (394933)

“…We attribute this paradoxical result to (1) strong selection on optimal offspring sizes, unaffected by parity mode, (2) the lack of a larval stage in amniotes, favouring large eggs even in the ancestral oviparous mode, and (3) the ability of viviparous females to decrease the mass of uterine embryos by reducing extra-embryonic water stores. …”

MUS81 causes DNA double-strand breaks upon Chk1 inhibition that result in cell death. by Josep V. Forment (119177)

“…Neutral comet assays were performed on cells transfected with siLuc or siMus81 #2 and then treated with 200 nM AZD7762 or 500 nM CEP-3891 for 5 h, or transfected with siChk1 as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023517#pone-0023517-g001" target="_blank">Fig. 1D</a>. …”

ndrg4 function is required for the expression of several genes that are essential for vesicle docking. by Laura Fontenas (3371204)

“…<p>(A) qPCR showing a significant decrease in the expression of nsfa, syt1a, stxbp1b but not vamp2 in ndrg4 mutants with mRNA relative expression to ef1a. …”

TMP blocks angiogenesis in vitro. by Xiaoxiao Cai (520170)

“…Original magnification, ×100. The error bars represent the s.d. of the mean. …”

Effects of paclitaxel on the total length of neurites per cell in control and treated DRG cultures. by Elena E. Ustinova (283017)

“…Pac was added to cultures at concentrations 0.1 nM–100 nM. As shown, Pac decreases the length of neurites in a concentration-dependent manner both in control (solid bars) and TLR4 knockout mice (open bars). *, p<0.05 versus 0 M of Pac in the same group; #, p<0.05 versus wild type at the same concentration of Pac. …”

Progression index. by Enedino Hernández-Torres (816735)

“…(B) Age-matched patients were divided in high 100*PI (>20) and low 100*PI (<20). Note that R2* values in the low PI group are higher than in the high PI group, supporting the hypothesis of a decrease in R2* with disease progression.…”

Feasibility of CT radiomics to predict treatment response of individual liver metastases in esophagogastric cancer patients by Remy Klaassen (3903154)

“…Random forest (RF) models were generated to discriminate partial responding (PR, >65% volume decrease, including 100% volume decrease), and complete remission (CR, only 100% volume decrease) lesions from other lesions. …”

Quantitative Real-Time Polymerase Chain Reaction Measurement of <i>HLA-DRA</i> Gene Expression in Whole Blood Is Highly Reproducible and Shows Changes That Reflect Dynamic Shifts i... by Sara Cajander (2657173)

“…<div><p>Introduction</p><p>A decrease in the expression of monocyte surface protein HLA-DR (mHLA-DR), measured by flow cytometry (FCM), has been suggested as a marker of immunosuppression and negative outcome in severe sepsis. …”