At clinically relevant concentrations the anaesthetic/amnesic thiopental but not the anticonvulsant phenobarbital interferes with hippocampal sharp wave-ripple complexes-2 by Costas Papatheodoropoulos (78587)

“…The cross-correlation plot from another slice (b) illustrates the large decrease of function value during drug application at 100 μM. …”

Image_1_DALY trend and predictive analysis of COPD in China and its provinces: Findings from the global burden of disease study.tif by Mimi Zhai (13232313)

“…The ASR of DALY was 1445.53 per 100,000 people in 2017 and demonstrated a significant decrease. …”

Image_2_DALY trend and predictive analysis of COPD in China and its provinces: Findings from the global burden of disease study.tif by Mimi Zhai (13232313)

“…The ASR of DALY was 1445.53 per 100,000 people in 2017 and demonstrated a significant decrease. …”

Activation of AMPK prevented drug-induced hepatocellular injury and hepatocyte depolarization. by Sun Woo Sophie Kang (3280878)

“…After hepatocytes were treated with various concentrations of acetaminophen (APAP) or diclofenac (Diclo), dose-viability response curves were obtained for (<b>A</b>) acetaminophen (1–20mM, 24hr) in rat hepatocytes, (<b>B</b>) diclofenac (50–800μM, 24hr) in rat hepatocytes, (<b>C</b>) acetaminophen (1–50mM, 24hr) in human hepatocytes, and (<b>D</b>) diclofenac (100–3000μM, 24hr) in human hepatocytes. …”

Nefopam inhibits cell viability in cultures from aggressive fibromatosis and hypertrophic cutaneous wounds. by Raymond Poon (12265)

“…The mean value for the cell culture treated with carrier was arbitrarily defined as 100 for each cell type. A) Data for a dose of 10 µM of Nefopam. …”

Semiparametric pairwise model outperforms other models. by Jan Humplik (4445659)

“…<b>D)</b> Average (across neurons) error rate decrease achieved by using a semiparametric pairwise model instead of a K-pairwise model for subpopulations of various sizes. …”

Superoxide flashes induce mitochondrial depolarizations, independently from the activity of the permeability transition pore. by Sandrine Pouvreau (240917)

“…Note the spatial and temporal colocalization of the increase in RPmt and decrease in TMRM fluorescence. <b>C</b> Total area of mitochondria presenting a flash or a depolarization per 1000 µm² cell per 100 s, in 5 cells under control conditions and after 20 min of treatment with 15 mM tiron (*: p<0.05 for control vs tiron, paired Wilcoxon Signed Rank test). …”

OSM activates ERK-1/2, SAPK/JNK-1/2 MAP kinases, the PI3-kinase Akt and STAT1/3 in HCT116 cells and STAT3 activation is dependent of the LIFR. by Florian Beigel (174724)

“…<p>(A) Stimulation with OSM (100 ng/mL) resulted in increased phosphorylation of ERK-1/2, SAPK/JNK-1/2 kinases and induced PI3 kinase-dependent Akt phosphorylation. …”

Effect of heparanase on activation of T lymphocytes. by Menachem Bitan (365486)

“…Addition of heparanase to the culture medium resulted in a significant (p<0.01) dose dependent decrease in ConA activation and proliferation of the spleen cells. …”

Table 1_The impact of percutaneous endoscopic gastrostomy on nutritional status and survival in cervical esophageal cancer patients undergoing chemoradiotherapy.docx by Zijun Wen (21596450)

“…The 2, 3, and 4 year OS rates for the PEG group were 81.9% (95% confidence interval [CI]: 63.2–100%), 54.3% (95% CI: 25.5–83.1%), and 32.6% (95% CI: 0.0–63.6%), respectively, while the Non-PEG group had 2, 3, and 4 year OS rates of 100% (95% CI: 83.0–100%), 82.1% (95% CI: 59.2–100%), and 49.2% (95% CI: 11.4–87.0%), respectively. …”

Experimental data for Atf3 and Egr1 regulation in cardiomyocytes exposed to ET-1 and modifications to the original mathematical model for the Atf3/Egr1 negative feedback system. by Marcus J. Tindall (243398)

“…<p>A, Experimental data for Atf3 mRNA (solid circles, solid line) and Atf3 protein (open circle, dashed line) levels in cardiomyocytes exposed to 100 nM ET-1 for the times shown. …”

Data_Sheet_1_Trends in mortality and causes of death among Chinese adolescents aged 10–19 years from 1990 to 2019.ZIP by Jiaxin Zhu (446571)

“…Regarding age, compared with those aged 10–14 years, the mortality rate of adolescents aged 15–19 years had a higher mortality (35.9/100,000 vs. 21.2 in 2019) and a slower decrease rate (percent: −57.6 vs. −63.2). …”

Reactions of NPY+ and ChAT+ interneurons to QA. by Qiqi Feng (535984)

“…Cont is short for control. Scale bars: A–D, 100 μm; A′–D′, 30 μm; B*, 10 μm.</p>…”

Oligodendrocyte ablation modifies the expression of axonal guidance molecules and neuronal plasticity markers. by Sandrine Doretto (221560)

“…Scale bar 100 µm. Quantification (expressed as % of control) of Netrin-1 shows a decrease of its expression in granule cell precursors of the external granular layer; while a concomitant increase of Sema3A expressed by Purkinje neurons is observed in MBP-TK mice versus WT siblings. …”

Anthocyanin-rich compounds extracted from bilberry and blackcurrants inhibit <i>in vitro</i> osteoclastogenesis, but not osteogenesis. by Sawako Moriwaki (563407)

“…B: Anti-osteoclastogenic activity of anthocyanin compound was evaluated by the absorption ratio of the red-stained area per well at 520 nm on a spectrometer. C: Primary osteoblastic cells were cultured in the medium containing 50 µg AA, 10 µM Dex and 10 mM β-GP with or without anthocyanin compound for 2 weeks. …”

Microarray analysis of 4HT, endoxifen and ICI action in the absence of estrogen. by John R. Hawse (227611)

“…<p>(<b>A</b>) Venn diagram of genes whose expression levels were determined to be significantly altered by 100 nM concentrations of 4HT, endoxifen or ICI in the absence of estrogen following 24 hours of regardless of fold-change levels. …”

Changes in the Bacterial Community Structure of Remediated Anthracene-Contaminated Soils by Laura Delgado-Balbuena (3211080)

“…On the one hand, application of earthworms removed most of the contaminant from the arable soil and had a strong effect on the bacterial community structure, i.e. a decrease in the relative abundance of the Acidobacteria, Chloroflexi and Gemmatimonadetes, and an increase in that of the Proteobacteria compared to the unamended soil. …”

<i>In vivo</i> analysis of the P1' Specificity of the pTEV2 protease. by Christian Renicke (585725)

“…<b>B</b>) Quantification of the P1' Specificity of the pTEV2 protease. Decrease of full length tester construct after two hours was normalized to initial values and relative efficiency normalized to proline was calculated (cleavage efficiency = ([X]_2h/[Pro]_2h×100-100) ×(−1)), assuming that the recognition sequence with proline at the P1’ Position is not cleaved at all. …”

<i>Sox10</i>-GFP^neg OPCs do not rescue the myelination phenotype in adult mice. by Shayan Moghimyfiroozabad (19066182)

“…<p>(A) Low magnification of a coronal brain section of adult mouse immunostained for myelin basic protein (MBP, magenta) and 2′,3′-Cyclic nucleotide 3′-phosphodiesterase (CNP, red) illustrates the almost total absence of myelination in the dorsal forebrain upon genetic ablation of <i>C1ql1</i>-expressing OPCs (upper panel). …”

Trends in prostate cancer mortality in the state of São Paulo, 2000 to 2015 by Carolina Terra de Moraes Luizaga (10434025)

“…RESULTS For the state of São Paulo, age-adjusted mortality rates were 15.2, 13.3 and 11.9 per 100,000 men, respectively, in the periods between 2000 to 2005, 2006 to 2010 and 2011 to 2015, with a significant decrease trend (AAPC = -2.10%; 95%CI -2.42 – -1.79) each year. …”