Age-related increase of neuronal stress in forebrain-specific <i>Xpg</i> knockout mice. by Sander Barnhoorn (641837)

“…(D) Representative images of Mac2 immunostained sagittal brain sections of 26- and 52-week old <i>Emx1-Xpg</i> and <i>wt</i> mice showing Mac2-positive microgliosis and a progressive decrease in size of the cerebral cortex and hippocampus of <i>Emx1-Xpg</i> mice. …”

<i>vang-1(tm1422)</i> life span modulation depends on Insulin/IGF-1-like signaling and leads to higher DAF-16 activity. by Sebastian J. Honnen (183696)

“…In contrast, depletion of DAF-16 by RNAi in <i>tm1422</i> (rose spotted line) and WT (purple solid line) causes a decrease of mean life span to <b>12±0.3 d</b> (n = 247*) and <b>11.9±0.2 d</b> (n = 142*), respectively (p<0.96**). …”

Evidence for Substrate Preorganization in the Peptidylglycine α-Amidating Monooxygenase Reaction Describing the Contribution of Ground State Structure to Hydrogen Tunneling by Neil R. McIntyre (2249155)

“…The first step, the copper-, ascorbate-, and O₂-dependent stereospecific hydroxylation at the α-carbon of the C-terminal glycine, is catalyzed by peptidylglycine α-hydroxylating monooxygenase (PHM). …”

Evidence for Substrate Preorganization in the Peptidylglycine α-Amidating Monooxygenase Reaction Describing the Contribution of Ground State Structure to Hydrogen Tunneling by Neil R. McIntyre (2249155)

“…The first step, the copper-, ascorbate-, and O₂-dependent stereospecific hydroxylation at the α-carbon of the C-terminal glycine, is catalyzed by peptidylglycine α-hydroxylating monooxygenase (PHM). …”

Evidence for Substrate Preorganization in the Peptidylglycine α-Amidating Monooxygenase Reaction Describing the Contribution of Ground State Structure to Hydrogen Tunneling by Neil R. McIntyre (2249155)

“…The first step, the copper-, ascorbate-, and O₂-dependent stereospecific hydroxylation at the α-carbon of the C-terminal glycine, is catalyzed by peptidylglycine α-hydroxylating monooxygenase (PHM). …”

Feijoa F3 activates autophagy and inhibits NF-κB activity in HCT15 cells. by Noha Ahmed Nasef (760610)

“…A percentage of greater than 100 shows increased inflammatory response in the presence of the ligand when compared to media (no treatment); and a percentage of less than one suggests a decrease in the inflammatory response in the presence of the ligand when compared to media (no treatment) meaning that a condition has inhibited NF-κB signaling. …”

Effect of hypotonic stress and elevated K⁺ on the ECS diffusion parameters in α-syn +/+ and α-syn −/− mice <i>in vitro</i>. by Lesia Dmytrenko (431060)

“…The mean values of the maximum change during application correspond to the time-point of the maximum decrease of α (i.e., the 25^th min in H-50 and H-100 and the 30^th min in 10 mM K⁺); the values for washout correspond to the data point at the 90^th min. …”

<i>klf4</i> is required for the maintenance of the <i>egc</i>^<i>+</i><i>/meg-1</i>^<i>+</i><i>/zfp-1-1</i>^<i>+</i> TRL. by Lu Zhao (296389)

“…(F) FISH depicting a modest decrease in <i>tsp-2</i>⁺ cell number following <i>klf4</i> RNAi. …”

Uniform downscaling of postsynaptic AMPA receptors across the dendritic tree in primary hippocampal cultures. by Mathieu Letellier (6803699)

“…(B) Representative EPSC trace evoked by a pair of brief depolarizations (+100 mV, 50-ms interval) of the presynaptic neuron. …”

Image5_The effect of ginger extract on cisplatin-induced acute anorexia in rats.TIFF by Hyeonah Kim (17359114)

“…Among these, acute anorexia is one of the most severe secondary effects. In this study, a single oral administration of 100 or 500 mg/kg ginger extract (GE) significantly alleviated the cisplatin-induced decrease in food intake in rats. …”

Image1_The effect of ginger extract on cisplatin-induced acute anorexia in rats.TIF by Hyeonah Kim (17359114)

“…Among these, acute anorexia is one of the most severe secondary effects. In this study, a single oral administration of 100 or 500 mg/kg ginger extract (GE) significantly alleviated the cisplatin-induced decrease in food intake in rats. …”

Image2_The effect of ginger extract on cisplatin-induced acute anorexia in rats.TIF by Hyeonah Kim (17359114)

“…Among these, acute anorexia is one of the most severe secondary effects. In this study, a single oral administration of 100 or 500 mg/kg ginger extract (GE) significantly alleviated the cisplatin-induced decrease in food intake in rats. …”

Image4_The effect of ginger extract on cisplatin-induced acute anorexia in rats.TIFF by Hyeonah Kim (17359114)

“…Among these, acute anorexia is one of the most severe secondary effects. In this study, a single oral administration of 100 or 500 mg/kg ginger extract (GE) significantly alleviated the cisplatin-induced decrease in food intake in rats. …”

Image6_The effect of ginger extract on cisplatin-induced acute anorexia in rats.TIFF by Hyeonah Kim (17359114)

“…Among these, acute anorexia is one of the most severe secondary effects. In this study, a single oral administration of 100 or 500 mg/kg ginger extract (GE) significantly alleviated the cisplatin-induced decrease in food intake in rats. …”

Image3_The effect of ginger extract on cisplatin-induced acute anorexia in rats.TIF by Hyeonah Kim (17359114)

“…Among these, acute anorexia is one of the most severe secondary effects. In this study, a single oral administration of 100 or 500 mg/kg ginger extract (GE) significantly alleviated the cisplatin-induced decrease in food intake in rats. …”

Treatment Satisfaction and Well-Being in Patients with Myopic Choroidal Neovascularization Treated with Ranibizumab in the REPAIR Study by Winfried M. Amoaku (748780)

“…Treatment satisfaction significantly increased over the study period (<i>p</i> = 0.0001). Mean MacTSQ scores increased by 9.7 and 10.0 in patients treated in their WSE and BSE, respectively. …”

BV and GSK3β siRNA modulate the levels of cytokines in the supernatants of cultured splenocytes. by Ran Fu (434520)

“…<p>Both BV (100 μg/mL) and GSK3β siRNA (100 pmol/mL) were shown to significantly decrease the levels of IL-4, but increase the levels of IL-10 and TGF-β1 in the supernatants of cultured splenocytes. …”

Mechanosensitive response in <i>pain</i> loss of function individuals. by Sébastien Sénatore (80383)

“…In the three mutants and in the RNAi line, a significant decrease is observed following <i>painless</i> knock-down. …”

Data_Sheet_1_Polygenic Risk Score for Early Prediction of Sepsis Risk in the Polytrauma Screening Cohort.docx by Hongxiang Lu (2947089)

“…Genetic variants with mean decrease accuracy (MDA) > 1.0 by random forest algorithms were selected to construct the multilocus wGRS. …”

Image_1_Polygenic Risk Score for Early Prediction of Sepsis Risk in the Polytrauma Screening Cohort.TIF by Hongxiang Lu (2947089)

“…Genetic variants with mean decrease accuracy (MDA) > 1.0 by random forest algorithms were selected to construct the multilocus wGRS. …”