Progress toward implementing the Swiss Hepatitis Strategy: Is HCV elimination possible by 2030? by Beat Müllhaupt (416436)

“…Given the current standard of care, total viremic infections are expected to decline by 45%, while cases of decompensated cirrhosis, hepatocellular carcinoma, and liver-related deaths will decrease by 20%. If treatment and diagnosis efforts were to cease in 2018, late stage HCV-related morbidity and mortality would increase by 90–100% by 2030. …”

X-ChIP based affinity purification provides the most inclusive analysis of nucleoid associated proteins. by Nina Rajala (693865)

“…The pie-chart shown here illustrates the distribution of the 366 enriched proteins identified with the X-ChIP method in regular HEK293 TwinkleFLAG and measured in HEK293 TwinkleFLAG ρ° in the following classes: not detected (absent), 95 proteins; ≥2 fold decrease, 163 proteins; no change, 100 proteins or ≥2 fold increase, 8 proteins(see also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116726#pone.0116726.s004" target="_blank">S3 Table</a>). …”

Arginine-dependent mRNA destabilization. by Tamar Ben-Zvi (3175077)

“…Putrescine can be produced from ornithine via <i>speC</i> and <i>speF</i> encoding a constitutive and inducible ornithine decarboxylase, respectively or from arginine in two steps via <i>speA</i> and <i>speB</i> encoding arginine decarboxylase agmatine ureohydrolase respectively. …”

PMN-MDSC induce EMT in vitro and in vivo. by Benjamin Toh (204080)

“…Red, S100A4; blue, Heamatoxylin (Nuclear stain). Panel I shows a decrease in the percentage of S100A4⁺ cells in the tumors depleted from PMN-MDSC (depletion scheme A). …”

Contribution of anti-gp120 antibodies to the overall neutralizing activity of HIV+ plasmas. by Iliyana Mikell (120166)

“…<p>(A) Log10 decrease in neutralizing activity caused by the elimination of anti-gp120 antibodies, and (B) Log10 decrease in neutralizing activity of plasmas in the presence of D368R. …”

DataSheet1.DOCX by Alexander H. Turaihi (4995452)

“…In these experiments insulin (10.0 nM) increased diameter in the presence of IRS2^+/+ PVAT (17 ± 4.8, p = 0.014), yet induced a 10 ± 7.6% decrease in diameter in the presence of IRS2^−/− PVAT. …”

Homolog pairing and sister chromatid cohesion in interphase remain unaffected genome-wide after knockdown of Rad21. by T. Niroshini Senaratne (3067776)

“…A simple separation of sister chromatids would be expected to cause a decrease in the percentage of nuclei with a single FISH signal, or an increase in the area of FISH signals; we observed neither (see main text for details).…”

DataSheet_2_In Patients With Obesity, the Number of Adipose Tissue Mast Cells Is Significantly Lower in Subjects With Type 2 Diabetes.docx by David Lopez-Perez (10842069)

“…Since mast cell progenitors cannot arrive at WAT, the amount of WAT mast cells depends on how the new microenvironment affects progenitor and differentiated mast cells. Here, we employed a flow cytometry-based approach to analyze the number of mast cells from omental white adipose tissue (o-WAT) and subcutaneous white adipose tissue (s-WAT) in a cohort of 100 patients with obesity. …”

<i>T. cruzi</i> infection alters host blood lipid profile and cardiac cholesterol level. by Fnu Nagajyothi (37087)

“…Results are presented as % difference compared to uninfected RD fed mice at day 0 post infection(d0 pi = 100%). (<b>c</b>) Analysis of total cholesterol (TC) levels in the RD fed mice showed a significant decrease (p≤0.005) even at 15 dpi compared to uninfected mice (n = 5). …”

Pd nanocrystals encapsulated in MOF-derived Ni/N-doped hollow carbon nanosheets for efficient thermal CO oxidation: unveiling the effect of porosity by Ipadeola, Adewale K.

“…This is evidenced in the great ability of Pd/Ni-MOF-HNC to utterly oxidize CO at a lower complete conversion temperature (T100) of 114.5 °C compared with Pd/Ni-MOF-NC (153.8 °C) and Pd/C (201.5 °C) under atmospheric pressure. …”
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Low cost microcontroller-based inverter integrated in PV systems by Salmi, Tarak

“…This would increase the efficiency and decrease the leakage current. The control strategy of the proposed topology is based on a low cost microcontroller interfaced to two drivers to step up the MOSFETs gate voltages. …”
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TRAIL pathway and the gene-gene interaction. by Yin-Ping Zhang (260509)

“…<p>The binding of TRAIL to TRAILR2 may induce the apoptosis of osteoclast. Increased c-FLIP levels may decrease the apoptosis of Osteoclast. …”

Revisiting aneuploidy profile of surgically retrieved spermatozoa by whole exome sequencing molecular karyotype by Stephanie Cheung (254096)

“…The assessment by FISH evidenced 2.8% chromosomal defects in the ejaculated and 1.2% in testicular biopsies while by NGS became 8.4% and 1.3% (<i>P</i> = 0.02), respectively. Interestingly, we evidenced a pregnancy rate of 0% with ejaculated while 100% with the testicular spermatozoa in this latter group. …”

Data_Sheet_1_Increase of Albinistic Hosts Caused by Gut Parasites Promotes Self-Transmission.docx by Shuqian Tan (5494841)

“…In addition, there was a decrease in phenol oxidase activity and the expression of henna and pale, which are involved in the synthesis of cuticle melanin, decreased. …”

Image_1_Different Renal Function Patterns in Patients With Acute Heart Failure: Relationship With Outcome and Congestion.jpeg by Alberto Palazzuoli (12203753)

“…The primary outcome was the combined endpoint of 180 days including all causes of mortality and re-hospitalization.</p>Results<p>We recruited 467 subjects with a mean congestion score of 3.5±1.08 and a median creatinine value of 1.28 (1.00–1.70) mg/dl, eGFR 50 (37–65) ml/min/m² and NTpro B-type natriuretic peptide (BNP) 7,000 (4,200–11,700) pg/ml. …”

Image_2_Different Renal Function Patterns in Patients With Acute Heart Failure: Relationship With Outcome and Congestion.jpeg by Alberto Palazzuoli (12203753)

“…The primary outcome was the combined endpoint of 180 days including all causes of mortality and re-hospitalization.</p>Results<p>We recruited 467 subjects with a mean congestion score of 3.5±1.08 and a median creatinine value of 1.28 (1.00–1.70) mg/dl, eGFR 50 (37–65) ml/min/m² and NTpro B-type natriuretic peptide (BNP) 7,000 (4,200–11,700) pg/ml. …”

DataSheet_1_Rapid Emergence of T Follicular Helper and Germinal Center B Cells Following Antiretroviral Therapy in Advanced HIV Disease.xlsx by Chun-Shu Wong (6750368)

“…The early events of immune recovery of T cells and B cells in severely lymphopenic HIV⁺ patients have not been fully characterized. In a cohort of lymphopenic (CD4 T-cell count < 100/µL) HIV⁺ patients, we studied mononuclear cells isolated from peripheral blood (PB) and lymph nodes (LN) pre-ART (n = 40) and 6-8 weeks post-ART (n = 30) with evaluation of cellular immunophenotypes; histology on LN sections; functionality of circulating T follicular helper (cTfh) cells; transcriptional and B-cell receptor profile on unfractionated LN and PB samples; and plasma biomarker measurements. …”

Image_1_Therapy With Different Dose Regimens of Rituximab in Patients With Active Moderate-To-Severe Graves’ Orbitopathy.tif by Irene Campi (10531166)

“…Primary endpoint was disease inactivation, measured as a decrease of the Clinical Activity Score (CAS) of at least two points. …”

Presentation_1_Rapid Emergence of T Follicular Helper and Germinal Center B Cells Following Antiretroviral Therapy in Advanced HIV Disease.pptx by Chun-Shu Wong (6750368)

“…The early events of immune recovery of T cells and B cells in severely lymphopenic HIV⁺ patients have not been fully characterized. In a cohort of lymphopenic (CD4 T-cell count < 100/µL) HIV⁺ patients, we studied mononuclear cells isolated from peripheral blood (PB) and lymph nodes (LN) pre-ART (n = 40) and 6-8 weeks post-ART (n = 30) with evaluation of cellular immunophenotypes; histology on LN sections; functionality of circulating T follicular helper (cTfh) cells; transcriptional and B-cell receptor profile on unfractionated LN and PB samples; and plasma biomarker measurements. …”

DataSheet_1_Rapid Emergence of T Follicular Helper and Germinal Center B Cells Following Antiretroviral Therapy in Advanced HIV Disease.xlsx by Chun-Shu Wong (6750368)

“…The early events of immune recovery of T cells and B cells in severely lymphopenic HIV⁺ patients have not been fully characterized. In a cohort of lymphopenic (CD4 T-cell count < 100/µL) HIV⁺ patients, we studied mononuclear cells isolated from peripheral blood (PB) and lymph nodes (LN) pre-ART (n = 40) and 6-8 weeks post-ART (n = 30) with evaluation of cellular immunophenotypes; histology on LN sections; functionality of circulating T follicular helper (cTfh) cells; transcriptional and B-cell receptor profile on unfractionated LN and PB samples; and plasma biomarker measurements. …”