RAGE blocking and APP inhibition synergistically reduce oxidative stress, apoptosis and rescue sequential gliocentric cell fate change in DS HNPs. by Jie Lu (139953)

“…(B) Graphs show the S100B stimulation for 24 hours dose dependently increase H₂O₂ production and decrease mitochondrial membrane potential which can be blocked by RAGE antibody (1 µg/ml) or dalteparin sodium (1 IU/ml) (<b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0022126#pone.0022126.s005" target="_blank">Figure S5A</a></b>). …”

Effect of sagopilone (SAG) on cell proliferation, tubulin cytoskeleton, cell cycle and apoptosis of lung cancer cells. by Sebastian Winsel (222664)

“…A549 cells were incubated for 72 hrs with vehicle, or 2.5 nM, 5 nM, 10 nM, 40 nM, or 100 nM SAG. …”

Steady state flux and G6P and F6P concentrations. by Maria José Ramírez-Bajo (515922)

“…<p>Decrease of flux of steady-state TrP production from Glc (A,D) and maintenance of G6P (B,E) and F6P (C,F) steady-state concentrations, in the presence of different pre-incubating concentrations of metals. …”

Representative Macro- and Microscopic Traces of Different MthK Constructs Expressed in E. coli Membrane by Mario Meng-Chiang Kuo (376172)

“…A single-channel trace with two active channels shows that the open probability does not decrease in the Ca²⁺ solution. …”

Effect of cycloheximide on development of <i>tko</i>^<i>25t</i> and wild-type flies. by Esko Kemppainen (64909)

“…Based on pairwise <i>t</i> tests, and considering all the flies of a given sex and genotype cultured at a specific drug concentration as a single population, mean eclosion times were significantly different (<i>p</i> < 0.05) at different cycloheximide concentrations, apart from <i>tko</i>^<i>25t</i> flies of either sex at 100 μg/ml, which were not different from <i>tko</i>^<i>25t</i> flies cultured in the complete absence of the drug. …”

Fig 4 - by Mohammad Ordikhani (13171002)

“…<b>Step 2</b>: Either increase or decrease the selected gene with the same probability. …”

The contributions of the saturable and non-saturable components to total flux of [³H]-ADMA into the capillary depletion samples are plotted against the unlabelled ADMA c... by Mehmet Fidanboylu (343341)

“…<p>The measured values are the mean ±SEM for 4-5 mice (homogenate), 4-5 mice (supernatant) and 5 mice (pellet except at 100 μM where it was 1 mouse) at each of the 6 ADMA concentrations and has been [¹⁴C]-sucrose corrected. …”

Global assessment of methylation levels and confounders contributing to hypomethylation in common CNV regions. by Corey T. Watson (250356)

“…Each plot shows a 100 bp moving average. Although a small decrease in methylation level is evident within CNVs compared to flanking regions, overall mean methylation levels within CNV regions (69%) are very similar to the genome average (70%). …”

The adhesion genes are activated by TAp63β but not by ΔNp63β in Caski cells. by Youcef Ben Khalifa (203743)

“…<p>(A) Real-time PCR performed in Caski cells infected with recombinant adenoviruses expressing GFP compared to TAp63β (upper panel) or ΔNp63β (lower panel) at increasing m.o.i. (20, 50 and 100). …”

DYNLT1 knockdown aggravates hypoxia-induced damage of mitochondria: mPT induction, MMP disruption and reduction of cellular viability. by Ya-dong Fang (338292)

“…<b>C</b>, −DYNLT1 cells showed a dramatic decrease in cell viability compared with WT and +DYNLT1 cells; WT and +DYNLT1 cells were not significantly different. …”

P2rx7 participates in the regulation of the basal BDNF expression in the mouse hippocampus. by Cecilia Csölle (425362)

“…The inhibitory effect of BzATP (100 µM) could be counteracted using CNQX (10 µM), the non-NMDA-type glutamate receptor antagonist, TCN-201 (10 µM), the NMDA-NR1/NR2A glutamate receptor antagonist and RO-256981 (3 µM) the NMDA-NR2B glutamate receptor antagonist but not using MCPG (200 µM), the group I mGluR antagonist. …”

Supplementary Material for: NANLING: Roxadustat effectiveness/safety in chronic kidney disease-associated anemia with peritoneal dialysis by figshare admin karger (2628495)

“…Baseline hemoglobin was 98.1 ± 10.7 g/L and was <80 g/L in 10 (5.1%). The mean [95% confidence interval] proportion who achieved a hemoglobin concentration ≥100 g/L was 85.1% [79.8%, 90.5%] (T2DM: 89.2% [78.5%, 99.9%]; non-DM: 84.0% [77.8%, 90.1%]). …”

Apyrase treatment removes extracellular ATP. by Isabel R. Orriss (432214)

“…<p>(<b>A</b>) Within one minute of 0.5U/ml apyrase treatment, a rapid decrease in ATP levels was observed; by 2 minutes and for the remainder of the experiment (10 minutes) ATP levels were negligible. …”

Pharmacological suppression of local activity abolishes non-linear interactions. by Michael T. Lippert (410615)

“…<p>A: General decrease in average rectified current source density (AVREC) caused by muscimol application (100 ms post-stimulus window, mean of both unisensory stimuli, n = 5, <i>P</i><0.05, U test). …”

Reelin is secreted by GABAergic neurons. by Cecilia Gonzalez Campo (264260)

“…Treatment with BFA did not change the proportion of intense reelin IR neurons: 21.1±1.2% before treatment (n = 8) and 21.0±1.9% after 16 hours (n = 6), whereas it caused a significant decrease in the fraction of punctate reelin IR neurons. …”

Effect of topical applications of EHNA on the incidence and multiplicity of histologically characterized skin tumors in high risk SKH-1 mice previously treated with UVB. by Jamie J. Bernard (645781)

“…These tumor-free mice with a high risk of developing skin tumors were treated topically with 3.1 µmole or 0.8 µmole of erythro-9-(2-hydroxy-3-nonyl) adenine hydrochloride (EHNA hydrochloride) or 6.2 µmole caffeine in 100 µl acetone:water (8∶2) once a day five days a week for 16 weeks. …”

Metalloproteinases cleave CD13 from the surface of FLS. by Rachel L. Morgan (3132747)

“…<p>Five different protease inhibitors were added to FLS cultures covering all classes of proteases. <b>(A)</b> The only inhibitor to decrease shedding of CD13 into the supernatant of the cultures was GM6001. …”

Effects of blocking degradation on reconsolidation and extinction. by Remus Osan (3639754)

“…Bars (mean ± S.E.M. of 100 simulations) indicate freezing percentages after initial learning with <i>S</i> = 0.8 (red) and after an intermediate reexposure session (<i>t</i> = 6) with vehicle (<i>S</i> = 0.8, <i>D</i> = 1.25, dark blue), anisomycin (<i>S</i> = 0, <i>D</i> = 1.25, light blue), degradation blockade (<i>S</i> = 0.8, <i>D</i> = 0, light gray) or anisomycin+degradation blockade (<i>S</i> = 0, <i>D</i> = 0, dark gray). …”

QUANTIFICATION OF NEURAL ELEMENTS IN POSTERIOR CRUCIATE LIGAMENT: COMPARISON BETWEEN HEALTHY KNEES AND WITH PRIMARY OSTEOARTHROSIS by MARCELO PARENTE OLIVEIRA (12679956)

“…Methods: In two groups with OA, one of cadavers and another of individuals, the area of neural elements identified in histological sections of PCL with anti-S100 immunohistochemistry was quantified. Results: The overall mean area of the neural elements was 0.96% ± 0.67%, with the value in the cadaver group of 1.02% ± 0.67% and in the OA group of 0.80% ± 0.64%, with a significant statistically difference (p = 0.001). …”

EPB-113 binds to hexameric nsp15 protein. by Benjamin Van Loy (9496075)

“…<p>(A) Thermal shift assay showing the decrease in T_m when 6 µM of nsp15 protein was incubated with 100 µM EPB-113. …”