Reaction Mechanism of the PET Degrading Enzyme PETase Studied with DFT/MM Molecular Dynamics Simulations by Carola Jerves (11383365)

“…The reaction mechanism takes place in two stages, acylation and deacylation, each of which occurs through a single, associative, concerted and asynchronous step. …”

Data_Sheet_5_Exploring the active ingredients and pharmacological mechanisms of the oral intake formula Huoxiang Suling Shuanghua Decoction on influenza virus type A based on netwo... by Ruying Tang (14036640)

DRLE had a cardioprotective effect. by Lung-Shuo Wang (3391244)

Ca²⁺ supplementation <i>in vitro</i> has no impact on the expression of CD69 by expanded Vγ2⁺ T cells and on the production of some cytokines by expanded huma... by Yusuf Cem Eskiocak (10789281)

Inhibition of ADP-induced P-selectin expression on platelets by deoxygenated erythrocytes + nitrite <i>in vitro</i>. by Attaphon Chamchoi (5774669)

Bar chart and logistic regression curve of combined gastrointestinal parasite (GIP) infection prevalence in Nepalese Gurkha recruits who migrated to the UK by year, 2012–2020. by William D. Nevin (17854751)

Image3_Circ-CDK8 regulates SLC7A11-mediated ferroptosis by inhibiting miR-615-5p to promote progression in oral squamous cell carcinomas.TIF by Kai Sun (140584)

“…Bioinformatics analyses and luciferase reporter assays were performed and revealed targeted relationships between circ-CDK8 and miR-615-5p, miR-615-5p and SLC7A11. Interference with circ-CDK8 expression reduced SLC7A11 expression by sponging miR-615-5p, suppressed OSCC cell migration and invasion, and promoted ferroptosis by increasing ROS, MDA, and iron levels and decreasing GSH and GPX4 levels in OSCC cells. …”

Image1_Circ-CDK8 regulates SLC7A11-mediated ferroptosis by inhibiting miR-615-5p to promote progression in oral squamous cell carcinomas.TIF by Kai Sun (140584)

“…Bioinformatics analyses and luciferase reporter assays were performed and revealed targeted relationships between circ-CDK8 and miR-615-5p, miR-615-5p and SLC7A11. Interference with circ-CDK8 expression reduced SLC7A11 expression by sponging miR-615-5p, suppressed OSCC cell migration and invasion, and promoted ferroptosis by increasing ROS, MDA, and iron levels and decreasing GSH and GPX4 levels in OSCC cells. …”

Table1_Circ-CDK8 regulates SLC7A11-mediated ferroptosis by inhibiting miR-615-5p to promote progression in oral squamous cell carcinomas.DOCX by Kai Sun (140584)

“…Bioinformatics analyses and luciferase reporter assays were performed and revealed targeted relationships between circ-CDK8 and miR-615-5p, miR-615-5p and SLC7A11. Interference with circ-CDK8 expression reduced SLC7A11 expression by sponging miR-615-5p, suppressed OSCC cell migration and invasion, and promoted ferroptosis by increasing ROS, MDA, and iron levels and decreasing GSH and GPX4 levels in OSCC cells. …”

Image2_Circ-CDK8 regulates SLC7A11-mediated ferroptosis by inhibiting miR-615-5p to promote progression in oral squamous cell carcinomas.TIF by Kai Sun (140584)

“…Bioinformatics analyses and luciferase reporter assays were performed and revealed targeted relationships between circ-CDK8 and miR-615-5p, miR-615-5p and SLC7A11. Interference with circ-CDK8 expression reduced SLC7A11 expression by sponging miR-615-5p, suppressed OSCC cell migration and invasion, and promoted ferroptosis by increasing ROS, MDA, and iron levels and decreasing GSH and GPX4 levels in OSCC cells. …”

Bar chart and logistic regression curve of yearly positive <i>S</i>. <i>stercoralis</i> results (both charcoal culture and IgG ELISA), in Nepalese Gurkha recruits who migrated to t... by William D. Nevin (17854751)

Cumulative percentage of positive diagnoses made by light microscopy following FEA concentration, depending on whether one, two or three stool samples were analysed, in Nepalese Gu... by William D. Nevin (17854751)

General laboratory tests and specific coagulation test in PCR SARS-CoV-2 positive patients with and without thrombosis. by B. de Laat (12475632)

Cell cycle progression is altered in DCT knockdown cells compared to control cells. by Pınar Aksoy (3663211)

<i>Gria1</i> and <i>Grin1</i> mRNA expressions in POMC neurons is impaired by the lack of <i>Efnb1</i> in POMC-expressing progenitors. by Manon Gervais (9708032)

Bar chart and logistic regression curve of yearly prevalence of hookworm infection in Nepalese Gurkha recruits who migrated to the UK 2012–2020. by William D. Nevin (17854751)

Bar chart and logistic regression curve of yearly prevalence of <i>T</i>. <i>trichiura</i> ova detection in Nepalese Gurkha recruits who have migrated to the UK 2012–2021. by William D. Nevin (17854751)

Depleting extracellular ATP reverts the mesenchymal phenotype of ovarian carcinoma cell lines. by José David Nuñez-Ríos (18823719)

FLIM-FRET measurements not affected by changes in expression levels or sedation method. by Xiaowen Jiang (8291814)

Overexpression of K⁺-leak channels and their effects on pectoral fin bud growth. by Xiaowen Jiang (8291814)