A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation... حسب Thirumal Kumar, D

"…In addition, the change of glutamate to lysine at position 17 of AKT1 (E17K) was found to be highly predominant. An extensive two-step molecular dynamics (simple and complex) simulation (MDS) using GROMACS (GROningen MAchine for Chemical Simulations) was then initiated to analyze and understand the structural impact of the E17K mutation on the function of AKT1. …"
احصل على النص الكامل
احصل على النص الكامل

The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans حسب Esh, Christopher J.

"…Random coefficient models determined relationships between Tc and COX/PGE2. Tc [mean (range)] increased in hot [+ 0.8 (0.4–1.2) °C; p < 0.0001; effect size (ES): 2.9], decreased in cold [− 0.5 (− 0.8 to − 0.2) °C; p < 0.0001; ES 2.6] and was unchanged in thermoneutral [+ 0.1 (− 0.2 to 0.4) °C; p = 0.3502]. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Effects of Trehalose Administration in Patients with Mucopolysaccharidosis Type III. حسب Mobini, Moein

"…Decreases in mean splenic length were observed, whereas the liver volume did not change. …"
احصل على النص الكامل
احصل على النص الكامل

Novel electroless deposited corrosion — resistant and anti-bacterial NiP–TiNi nanocomposite coatings حسب Fayyad E.M.

احصل على النص الكامل
احصل على النص الكامل

The Impact of Multiple Autoclave Cycles on the Surface Roughness of Thermally Treated Nickel-Titanium Endodontic Files حسب Ba-Hattab, Raidan

"…., 20 TN, 20 ETP, and 20 PTG files), and each group was divided into four equal subgroups of five files (n = 5). An unsterilized group was assigned as the pre-autoclaving group (Cycle 0), and the other three groups underwent various autoclave sterilization cycles (Cycles 1, 5, and 10). …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Adrenoceptor Desensitization: Current Understanding of Mechanisms حسب Maaliki, Dina

"…In this context, this review discusses the different patterns of desensitization of the α1-, α2- and the β adrenoceptors and highlights the role of β-arrestins in regulating physiologic responsiveness through desensitization and biased agonism. …"
احصل على النص الكامل
احصل على النص الكامل

Investigating the utilization of healthcare services to manage respiratory tract infections (RTIs) among Qatari patients attended selected primary healthcare centers in Qatar حسب Islam, Nazmul

"…Results: A total of 171,447 RTI visits made by 58,786 patients during July-2015 to December-2017. The Mean age ±SD of participants is 24.80±18.5 years, among them 38.79% falls to age group 5-19 and 33.53% belongs to 20-44. …"
احصل على النص الكامل

The Effect of Hyperoxia on Central and Peripheral Factors of Arm Flexor Muscles Fatigue Following Maximal Ergometer Rowing in Men حسب Volianitis, Stefanos

"…Results: Arterial hemoglobin O2 saturation was reduced to 92.5 ± 0.2% during exercise with normoxia but maintained at 98.9 ± 0.2% with hyperoxia. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Effect of binary mixture of waste plastics on the thermal behavior of pyrolysis process حسب Pek, Wee Kiat

"…It was also found that secondary reaction occurred when mixing two types of plastics. The activation energy of the first step pyrolysis reaction is also higher than the secondary reaction. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Nonlinear stochastic modeling for optimal dispatch of distributed energy resources in active distribution grids including reactive power حسب Mehrjerdi, Hasan

احصل على النص الكامل
احصل على النص الكامل

Urology Residents' Perspectives on the In-House On-Call Systems: A Study in an Accredited Academic Center حسب Khalil, Ibrahim A. and Ibrahim, Tarek and Aldeeb, Maya and Mohamed, Ahmed and Ben Salah, Rym and Aboumarzouk, Omar M. and Al-Naimi, Abdulla

"…Working hours: compliance and violations There was no significant difference in the mean weekly working hours (p = 0.1). However, the total number of duty hours violations decreased in the 12-hour on-call system. …"
احصل على النص الكامل
احصل على النص الكامل

Impact of fines type on gas flow using 3D micro-computed tomography حسب Al-Raoush, Riyadh

"…The qualitative and quantitative findings achieved in this work in 3D, agree with other observations in recent literature on 2D micromodels. Understanding the fluid physics in homogenous sand systems is an essential step to quantify fines impact on heterogeneous rock systems. …"
احصل على النص الكامل
احصل على النص الكامل

Impact of fines type on gas flow using 3D micro-computed tomography حسب Al-Raoush, Riyadh

"…The qualitative and quantitative findings achieved in this work in 3D, agree with other observations in recent literature on 2D micromodels. Understanding the fluid physics in homogenous sand systems is an essential step to quantify fines impact on heterogeneous rock systems. …"
احصل على النص الكامل

Fecal Carriage and Molecular Characterization of Carbapenemase-Producing Enterobacterales in the Pediatric Population in Qatar حسب Pérez-López, Andrés

"…All 9 blaOXA-48-type-gene-containing E. coli sequence type 38 (ST38) strains were isolated from patients without international travel history. The mean quarterly incidence of fecal carriage decreased more than 6-fold after the implementation of coronavirus disease 2019 (COVID-19)-related international travel restrictions in Qatar in mid-March 2020. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Demographic characteristics, laboratory features and complications in 346 cases of brucellosis: A retrospective study from Qatar حسب Varikkodan, Irfan

"…Results: Of the 346 patients 299 were males. The mean age was 39.62 years. 120 patients had history of drinking raw milk and 116 had a history of contact with animals. …"
احصل على النص الكامل
احصل على النص الكامل

Simulation and Optimization of an LNG Plant Cold Section حسب Katebah, Mary Anna

"…Using the short cut method, optimization revealed that optimized MR composition resulted in almost 10% MR compression power and 6% plant operating cost savings, whereas new intermediate propane evaporation pressures, identified using detailed simulation, and flowrates decreased the propane compression power and operating costs by around 3.6%, and 2%, respectively. …"
احصل على النص الكامل
احصل على النص الكامل

Response of cauliflower (Brassica oleracea L.) to nitric oxide application under cadmium stress حسب Jing, Ma

"…Our results illustrated that the increasing levels of Cd in the sand, significantly (P < 0.05) decreased shoot length, root length, shoot fresh weight, root fresh weight, shoot dry weight, root dry weight, germination percentage, germination index, mean germination time, time to 50% germination, chlorophyll a, chlorophyll b, total chlorophyll and carotenoid contents in all genotypes of B. oleracea. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

The Effects of Class IV Hemorrhagic Hypotensive Shock and Its Resuscitation with Fluids and Adjuvant Vasopressors or Cellular Energy Replenishment on the Splanchnic Microcirculatio... حسب Zakaria, El Rasheid

"…The transected organ was returned to the abdominal cavity for free arterial and venous bleeding until class IV hemorrhage is achieved [defined by persistent mean arterial pressure, MAP < 40 mmHg, and a shock index (ratio of heart rate and systolic arterial pressure), SI ≥ 5 for successive 10 minutes during the period of active uncontrolled bleeding]. …"
احصل على النص الكامل
احصل على النص الكامل

Fabrication of Selective Sensors for Hg2+ Traces in Water Using Graphene Decorated with Metal Nanoclusters حسب Ayesh, Ahmad I.

"…Nevertheless, previous studies estimated the allowed amount of inorganic Hg2+ in water to 0.5 ppb [5]. Therefore, the development of sensitive, selective, reliable, and cost effective Hg2+ sensors is needed for medical diagnostic, quality control of food industry, as well as water and environment quality monitoring. …"
احصل على النص الكامل
احصل على النص الكامل

Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach حسب P., Sneha

"…Missense mutations of the HNF1A were retrieved from public databases and subjected to a three-step computational mutational analysis to identify the underlying mechanism. …"
احصل على النص الكامل
احصل على النص الكامل