Responses of cells expressing various γ subunits to different concentrations of agonist. by Mariangela Chisari (257345)

“…<p><i>A.</i> M3-CHO cells expressing αq-CFP, YFP-γ (as indicated) and PH-mCh were imaged as mentioned in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0007797#s4" target="_blank">Methods</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0007797#pone.0007797.s006" target="_blank">Text S1</a>. …”

Image1_The clinical and genetic aspects of six individuals with GH1 variants and isolated growth hormone deficiency type II.tif by Xiaozhen Huang (5858690)

“…Background<p>Isolated growth hormone deficiency type II (IGHD II) is an autosomal dominant disorder characterized by a GH1 gene variant resulting in a significant reduction in growth hormone (GH) secretion and a subsequent decrease of plasma insulin-like growth factor 1 (IGF-1) levels and eventual growth impairment.…”

WIKI4 inhibits the functional outcomes of Wnt/ß-catenin signaling. by Richard G. James (114424)

“…(<b>C</b>) Treatment with WIKI4 prevents the decrease in co-expression of markers of undifferentiated hESCs following Wnt3A stimulus. hESCs were stimulated with the indicated treatments and expression of GCTM2 and CD9 was assessed by flow cytometry following six days of treatment. …”

Effects of the activation and inhibition of NOTCH signalling on spinal cord progenitor cell proliferation and neuronal generation. by Barbara Hämmerle (36261)

“…Higher magnification of a single optical section (5 µm) of the boxed region of F showing two double labelled cells. …”

Significantly enriched pathways after infection by EV-D94 or EV-D68 in respiratory and intestinal tissues. by Ines Cordeiro Filipe (5849144)

“…<p><b>A)</b>. Genes with average log2 fold change increase/decrease of 0.5 versus the mock were considered for pathway analysis. …”

Solution X-ray Absorption Fine Structure Study of the Eu²⁺ and Sr²⁺ Ions:  Unexpected Solvent and Metal Ion Dependencies of the Solvation Numbers by Gilles Moreau (3042738)

“…For both Eu²⁺ and Sr²⁺ ions, a decrease in coordination number (<i>N</i>) and metal-to-solvent distances was found along the increasingly solvating MeCN < H₂O ≪ DMF < DMSO solvent series:  for strontium, <i>N</i> = 8 with [Sr(MeCN)₈]²⁺ (2.665(6) Å) and [Sr(H₂O)₈]²⁺ (2.600(3) Å) and <i>N</i> = 7 with [Sr(DMF)₇]²⁺ (2.555(5) Å) and [Sr(DMSO)₇]²⁺ (2.540(7) Å); for europium(II), <i>N</i> = 8 with [Eu(MeCN)₈]²⁺ (2.640(4) Å), <i>N</i> = 7 with [Eu(H₂O)₇]²⁺ (2.584(5) Å), and <i>N</i> = 6 with [Eu(DMF)₆]²⁺ (2.541(3) Å) and by extrapolation [Eu(DMSO)₆]²⁺ (2.525 Å). …”

Table1_The clinical and genetic aspects of six individuals with GH1 variants and isolated growth hormone deficiency type II.docx by Xiaozhen Huang (5858690)

“…Background<p>Isolated growth hormone deficiency type II (IGHD II) is an autosomal dominant disorder characterized by a GH1 gene variant resulting in a significant reduction in growth hormone (GH) secretion and a subsequent decrease of plasma insulin-like growth factor 1 (IGF-1) levels and eventual growth impairment.…”

Hybrid stochastic framework predicts efficacy of prophylaxis against HIV: An example with different dolutegravir prophylaxis schemes by Sulav Duwal (152805)

“…<div><p>To achieve the 90-90-90 goals set by UNAIDS, the number of new HIV infections needs to decrease to approximately 500,000 by 2020. One of the ‘five pillars’ to achieve this goal is pre-exposure prophylaxis (PrEP). …”

Data_Sheet_1_Present and future distribution of Faidherbia albida in Cabo Verde as revealed by climatic modelling and LULC analysis.PDF by Danilson Varela (14799583)

“…On average, the predicted suitable habitat for future distributions gradually decreases by 2080 under both scenarios compared with the current, with a smaller effect of RCP4.5 than of RCP8.5. …”

Data_Sheet_1_Aerobic Vaginitis Induced by Escherichia coli Infection During Pregnancy Can Result in Adverse Pregnancy Outcomes Through the IL-4/JAK-1/STAT-6 Pathway.docx by Chong Fan (10533020)

“…Besides, pregnant status also aggravates the symptoms and consequences of the infection. Here, we infected pregnant BALB/c mice with Escherichia coli on embryonic day 4.5 (E4.5) (study group), and administered an equivalent volume of phosphate-buffered saline in another cohort of pregnant mice (control group). …”

Data_Sheet_1_Association of nocturnal sleep duration and midday napping with subjective poor hearing among middle-aged and older adults in China.docx by Xiaorui Cui (1595827)

“…Individuals with napping for 5 to ≤30 min had a 20% (HR: 0.80, 95%CI: 0.63, 1.00) lower risk of hearing loss compared with those with napping ≤ 5 min. …”

Image_1_Chemerin and PEDF Are Metaflammation-Related Biomarkers of Disease Activity and Obesity in Rheumatoid Arthritis.pdf by Barbara Tolusso (146649)

“…Moreover, after low-calories diet, RA with low-moderate disease activity reaching BMI reduction ≥5% (62.6%) at 6 months had significant decrease of PEDF (p < 0.05) and Chemerin (p < 0.05) plasma values, in parallel with the improvement in disease activity.…”

Table1_Effects of shading on morphology, photosynthesis characteristics, and yield of different shade-tolerant peanut varieties at the flowering stage.docx by Jing Wang (6206297)

“…Shade stress led to decreased dry-matter accumulation, reduced weight of 100 fruits and kernels, and a significant decline in yield in the shade-sensitive cultivars. …”

DataSheet1_The interplay of common genetic variants NRG1 rs2439302 and RET rs2435357 increases the risk of developing Hirschsprung’s disease.PDF by Shuiqing Chi (10298891)

“…NRG1 and RET double mutants caused the most severe reduction in enteric neuron numbers than NRG1 single mutant or RET single mutant in the hindgut of zebrafish. SHSY-5Y cells and IPSCs with rs2439302 GG/rs2435357 TT genotype exhibited a decreased proliferative, migration, and differentiative capacity. …”

Table_1_Chemerin and PEDF Are Metaflammation-Related Biomarkers of Disease Activity and Obesity in Rheumatoid Arthritis.doc by Barbara Tolusso (146649)

“…Moreover, after low-calories diet, RA with low-moderate disease activity reaching BMI reduction ≥5% (62.6%) at 6 months had significant decrease of PEDF (p < 0.05) and Chemerin (p < 0.05) plasma values, in parallel with the improvement in disease activity.…”

Prospective Study of the Quality of Colonoscopies Performed by Primary Care Physicians: The Alberta Primary Care Endoscopy (APC-Endo) Study by Michael R. Kolber (428008)

“…Patient satisfaction was captured by a telephone survey.</p><p>Setting</p><p>Thirteen rural and suburban hospitals in Alberta, Canada.…”

Data_Sheet_1_From acidophilic to ornithogenic: microbial community dynamics in moss banks altered by gentoo penguins.pdf by Yevheniia Prekrasna-Kviatkovska (18117865)

“…The contrasting composition of peat and penguin feces led to the elimination of the initial peat microbiota, with an increase in Betaproteobacteria (from 1.3 ± 0.8% to 30.5 ± 23%) and Bacteroidota (from 5.5 ± 3.7% to 19.0 ± 3.7%) proportional to the intensity of penguins’ impact, accompanied by a decrease in community diversity. …”

Image_2_Chemerin and PEDF Are Metaflammation-Related Biomarkers of Disease Activity and Obesity in Rheumatoid Arthritis.pdf by Barbara Tolusso (146649)

“…Moreover, after low-calories diet, RA with low-moderate disease activity reaching BMI reduction ≥5% (62.6%) at 6 months had significant decrease of PEDF (p < 0.05) and Chemerin (p < 0.05) plasma values, in parallel with the improvement in disease activity.…”

AgDscam Is Implicated in Phagocytosis of Bacteria by Yuemei Dong (17509)

“…<div><p>(A) AgDscam distribution in DAPI-stained Sua5B cells and co-localization with FITC-labeled bacteria [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0040229#pbio-0040229-b030" target="_blank">30</a>]. …”

Image_3_Chemerin and PEDF Are Metaflammation-Related Biomarkers of Disease Activity and Obesity in Rheumatoid Arthritis.pdf by Barbara Tolusso (146649)

“…Moreover, after low-calories diet, RA with low-moderate disease activity reaching BMI reduction ≥5% (62.6%) at 6 months had significant decrease of PEDF (p < 0.05) and Chemerin (p < 0.05) plasma values, in parallel with the improvement in disease activity.…”