β-Catenin regulates proliferation of prostatic duct progenitors. by Jeffrey C. Francis (107011)

“…A significant decrease in proliferation is evident after 5 days in culture, compared to control prostates (E18.5 p = 0.095, 5 days in culture p = 0.0016). …”

WV phase space projection for QIF model with spike waveform, and convergent iterative theoretical predictions for <i>μ</i> > <i>μ</i>* and <i>μ</i> → 0. by Adam D. Schneider (148548)

“…Inset shows the cyan trajectory in terms of decaying variables <i>x</i>*(<i>t</i>) and <i>C</i>*(<i>t</i>), and how <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0159300#pone.0159300.e084" target="_blank">Eq (22)</a> captures the initial increase and then decrease in the calcium concentration, while <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0159300#pone.0159300.e083" target="_blank">Eq (21)</a> does not. …”

Increasing dead cell burden in wounds resulted in increased pro-inflammatory cytokine levels. by Savita Khanna (252283)

“…Data (mean ±SD, n = 5) are presented as <i>pg</i> cytokine per <i>mg</i> wound tissue. *, <i>p</i><0.05 compared to IgG treated control side.…”

Jackknife analysis of the top environmental predictors used in the model. by Kylie M. Sage (4543402)

“…BIO5 = maximum temperature of the warmest month, BIO6 = minimum temperature of the coldest month, BIO8 = mean temperature of the wettest quarter, BIO7 = annual temperature range, BIO15 = precipitation seasonality, BIO18 = precipitation of the warmest quarter, elv = elevation.…”

Cytotoxic effect of antimicrobial peptides is related to the entry of peptides but not with the binding to the cell membrane. by Marcus V. Buri (491139)

Fetal growth standards for Somali population by Hiba J. Mustafa (7417595)

Image_2_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Kv7.4 channels co-expressed with wild-type (WT) CaM show inhibited activation when intracellular calcium levels increase, while Kv7.4 channels co-expressed with CaM₁₂₃₄ or CaM₃ are insensitive to calcium. Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Image_7_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Kv7.4 channels co-expressed with wild-type (WT) CaM show inhibited activation when intracellular calcium levels increase, while Kv7.4 channels co-expressed with CaM₁₂₃₄ or CaM₃ are insensitive to calcium. Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Image_4_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Kv7.4 channels co-expressed with wild-type (WT) CaM show inhibited activation when intracellular calcium levels increase, while Kv7.4 channels co-expressed with CaM₁₂₃₄ or CaM₃ are insensitive to calcium. Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Image_6_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Kv7.4 channels co-expressed with wild-type (WT) CaM show inhibited activation when intracellular calcium levels increase, while Kv7.4 channels co-expressed with CaM₁₂₃₄ or CaM₃ are insensitive to calcium. Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Image_8_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Kv7.4 channels co-expressed with wild-type (WT) CaM show inhibited activation when intracellular calcium levels increase, while Kv7.4 channels co-expressed with CaM₁₂₃₄ or CaM₃ are insensitive to calcium. Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Image_9_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Kv7.4 channels co-expressed with wild-type (WT) CaM show inhibited activation when intracellular calcium levels increase, while Kv7.4 channels co-expressed with CaM₁₂₃₄ or CaM₃ are insensitive to calcium. Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Data_Sheet_1_4DEMON: Integrating 40 Years of Data on PCB and Metal Contamination in Marine Sediments of the Belgian Part of the North Sea.docx by Hong Minh Le (10887786)

“…Trend analysis revealed a strong decrease in PCB concentrations in the nineteen eighties and nineties, followed by a slight increase over the last decade. …”

Image_1_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Kv7.4 channels co-expressed with wild-type (WT) CaM show inhibited activation when intracellular calcium levels increase, while Kv7.4 channels co-expressed with CaM₁₂₃₄ or CaM₃ are insensitive to calcium. Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Image_3_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Kv7.4 channels co-expressed with wild-type (WT) CaM show inhibited activation when intracellular calcium levels increase, while Kv7.4 channels co-expressed with CaM₁₂₃₄ or CaM₃ are insensitive to calcium. Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Validation of E. coli Signaling Network Model by Burton W Andrews (274358)

“…<div><p>(A) Response of the E. coli signaling network model is plotted for a 0.1-mM step increase in chemoattractant concentration from 0.2 mM at 10 s. …”

Chloroquine (CQ) treatment blocks autophagosome–lysosome fusion and induces myopathy in the larva. by Jonathan Zirin (483506)

“…(M) Quantification of autophagy changes due to <i>Atg</i> gene knockdown in <i>Dmef2</i>–<i>Gal4</i>, <i>UAS</i>–<i>GFP</i>–<i>Atg8</i> larvae starved on low-nutrient food +2.5 mg/ml CQ for 6 h. Each of the 10 <i>UAS</i>–<i>Atg</i> RNAi transgenes tested caused a highly significant decrease (<i>p</i><.01) in the total area of GFP–Atg8 vesicles. …”

DataSheet1_Inhibition of colon cancer K-RasG13D mutation reduces cancer cell proliferation but promotes stemness and inflammation via RAS/ERK pathway.PDF by Yan Qi (59532)

“…We found a close correlation of increased Lgr5 and CD133 with proinflammatory factors like IL-17, IL-22, and IL-23. …”

Data_Sheet_2_Exercise Capacity Is Improved by Levosimendan in Heart Failure and Sarcopenia via Alleviation of Apoptosis of Skeletal Muscle.xlsx by Di Wang (329735)

“…Therefore, levosimendan may be a potential drug for the treatment of heart failure with sarcopenia.…”

Data_Sheet_1_Exercise Capacity Is Improved by Levosimendan in Heart Failure and Sarcopenia via Alleviation of Apoptosis of Skeletal Muscle.PDF by Di Wang (329735)

“…Therefore, levosimendan may be a potential drug for the treatment of heart failure with sarcopenia.…”