Combinatorial Synthesis and in Vitro Evaluation of a Biaryl Hydroxyketone Library as Antivirulence Agents against MRSA by Guanping Yu (1345770)

“…An acylation bond-forming process afforded resorcinols (<b>1</b>) and aryloxy acetonitriles (<b>2</b>) as synthons. A Lewis-acid-activated Friedel–Crafts’ acylation step involving a nitrile functionality of <b>2</b> by ZnCl₂, followed by nucleophilic attack by <b>1</b> was executed to obtain biaryl hydroxyketones in excellent yields. …”

Combinatorial Synthesis and in Vitro Evaluation of a Biaryl Hydroxyketone Library as Antivirulence Agents against MRSA by Guanping Yu (1345770)

“…An acylation bond-forming process afforded resorcinols (<b>1</b>) and aryloxy acetonitriles (<b>2</b>) as synthons. A Lewis-acid-activated Friedel–Crafts’ acylation step involving a nitrile functionality of <b>2</b> by ZnCl₂, followed by nucleophilic attack by <b>1</b> was executed to obtain biaryl hydroxyketones in excellent yields. …”

CD68 immunoreactivity. by Carola I. F. Janssen (414818)

“…<p>In the CA1, we observed a genotype × diet interaction (p = 0.001), there was a trend for increased inflammation in WT after HF supplementation (p = 0.052). …”

Data_Sheet_1_Ultra-Low Oxygen and Preconditioning Storage Regulate Ethylene Synthesis to Prevent Corky Disorders in ‘Fuji’ Apple.docx by Camila Riaño (12693314)

“…In addition, a considerable reduction in ethylene production for up to 30 days was observed in ULO-treated fruit at 0 and 5^°C. …”

Measurement of intracellular Ca²⁺, [Ca²⁺]_i, levels showing strong cross-talk between TRPV4 and the KCa channels in mCCDcl1. by Yue Li (102191)

“…Addition of the 4 Blockers had not affect in the absence of GSK101 (-), averaging 0.4 ± 2.5 nM (n = 24). In the presence of GSK101 (+), the 4 Blockers induce a marked decrease in [Ca²⁺]_i of 477 ± 45 nM (n = 24, P<0.001) with the 4 Blockers, demonstrates a strong functional cross-talk between TRPV4, [Ca²⁺]_I, and KCa channels. …”

Gangliosides are required for viral capture mediated by mDC. by Nuria Izquierdo-Useros (91232)

“…Data show mean values and standard error of the mean (SEM) from five independent experiments including cells from at least six donors. mDCs capture significantly higher amounts of GM3-containing LUV_HIV-tRed than Cer or Ø LUV_HIV-tRed (<i>p</i><0.0001, paired <i>t</i> test). mDCs capture significantly higher amounts of GM1a-containing LUV_HIV-tRed than negatively charged PS-LUV_HIV-tRed (<i>p</i> = 0.0081, paired <i>t</i> test). …”

Cell cycle analysis of cardiomyoblasts using EdU incorporation. by Artem Shkumatov (551689)

“…Images represent EBs cultured in suspended state (A-1 and A-5) and on hydrogels with <i>E</i> of 0.2 (A-2 and A-5), 6 (A-3 and A-5), and 40 kPa (A-4 and A-5). …”

TSA on chronic pain data. by G. G. Koning (103625)

“…Lichtenstein anticipating a realistic relative risk decrease of chronic pain of 20% with TEP compared to Lichtenstein assuming a control event proportion of 17% and a type 1 error risk of 5% and a type 2 error risk of 20% (power = 80%). …”

Probing the auditory nerve using round-window response in control and ouabain-poisoned cochleae. by Charlène Batrel (3639406)

“…Note that below 2 kHz (light-coloured area), the neural index amplitude decreases because of the phase locked response of fibers and their cancelation by opposite polarities. …”

Erratum: Stroke Prevalence, Mortality and Disability-Adjusted Life Years in Adults Aged 20-64 Years in 1990-2013: Data from the Global Burden of Disease 2013 Study by Krishnamurthi R.V. (3236010)

“…Death rates for all strokes among younger adults also declined significantly in developed countries from 33.3 (95% UI 29.8-37.0) in 1990 to 23.5 (95% UI 21.1-26.9) in 2013. A significant decrease in HS death rates for younger adults was seen only in developed countries between 1990 and 2013 (19.8 (95% UI 16.9-22.6) and 13.7 (95% UI 12.1-15.9)) per 100,000). …”

Debromination of Polybrominated Diphenyl Ether Congeners BDE 99 and BDE 183 in the Intestinal Tract of the Common Carp (<i>Cyprinus carpio</i>) by Heather M. Stapleton (1278081)

“…In both exposure studies, the concentration of the exposure compound decreased significantly in the gut within 2.5 ± 1 h following ingestion. …”

Debromination of Polybrominated Diphenyl Ether Congeners BDE 99 and BDE 183 in the Intestinal Tract of the Common Carp (<i>Cyprinus carpio</i>) by Heather M. Stapleton (1278081)

“…In both exposure studies, the concentration of the exposure compound decreased significantly in the gut within 2.5 ± 1 h following ingestion. …”

Metabolic capacity of synaptosomes. by Ernst-Bernhard Kayser (2172865)

“…The only significant (α = 5%) change observed was a decrease with age in the controls (*) from cerebellum. …”

Binaphthoquinones inhibit yeast respiratory growth by depolarizing the mitochondrial membrane. by Ashkan Emadi (248270)

“…The peak shift toward the left represents a decrease of fluorescence signal of rhodamine 123 in the yeast, indicating the loss of mitochondrial membrane potential in the presence of BiQs as compared to no drug (DMSO) control.…”

The SPR analysis of SECRET-CX3CL1 interaction in the presence of heparin. by Xiaoguang Xue (211883)

“…<p>(A) Sensorgrams of passing CX3CL1 pre-incubated with an increased concentration of heparin (sodium salt, molecular weight ∼15 KD) (0, 0.125, 0.25, 0.5, 1, 2, and 4 mg/ml) through the CM5 chip surface immobilized with the SECRET domain. …”

Monitoring of growth and chemotherapy response in the model of visceral growing mPlum HT-29 xenografts. by Henrike Caysa (301868)

“…It becomes apparent that chemotherapy induced a clear decrease of FI indicating the response of tumors. …”

Protective effect of AICAR on the rhodopsin level and OS length during inflammation. by Mamoru Kamoshita (601804)

“…<p>(A, B) Immunoblot analysis. Rhodopsin protein in the retina was decreased during EIU, and this decrease was attenuated by AICAR, 24 hours after LPS injection. …”

Climate projections of chill hours and implications for olive cultivation in Minas Gerais, Brazil by Fabrina Bolzan Martins (7141982)

“…The present climate data were obtained from 47 conventional weather stations, and the future climate data were obtained from three Earth system models (IPSL-CM5A-LR, MRI-CGCM3, and MIROC5). Future projections point to a decrease in the suitable areas for olive crop cultivation, particularly under representative concentration pathway (RCP) 8.5 and for olive cultivars with a high-chilling requirement (Tb=7.0ºC). …”

Hypoxia activates autophagy in CD8 T cells. by Katelin N. Townsend (501754)

“…<p>(A) A representative Western blot indicating protein expression of HIF-1α, p62, LC3-II and β-actin is shown for OT-I CD8 T cells cultured under 1.5% oxygen. …”

Data from: Decade-long bird trends in China: Stable species richness but increasing biotic homogenization by Jiekun He (20964269)

“…We found that species richness remained stable over 10 years, with no directional trend at 84.5% of sites and a small mean effect size (Zr = 0.102, 95% CI = [-0.012; 0.216]). …”