Image_1_Epidemiological and demographic drivers of lung cancer mortality from 1990 to 2019: results from the global burden of disease study 2019.tif by Yaguang Fan (15415049)

“…Decomposition analysis was used to analyze the contributions of epidemiological and demographic drivers to lung cancer mortality.</p>Results<p>Despite a non-significant decrease in ASMR [EAPC = −0.31, 95% confidence interval (CI): −1.1 to 0.49], the number of deaths from lung cancer increased by 91.8% [95% uncertainty interval (UI): 74.5–109.0%] between 1990 and 2019. …”

Tau knockout prevents sensitivity to Kainic acid–mediated stress in AICD-Tg mice. by Kaushik Ghosal (244754)

“…C. Mean seizure severity scores showed a significant rescue of seizure severity by Tau-/- in AICD animals. n = 4–5 mice per group (A-C). …”

Thirty-year Trends in Complications in U.S. Adults With Newly Diagnosed Type 2 Diabetes by Michael Fang (9708234)

“…</p> <p><b>Results: </b>From 1988-1994 to 2011-2018, there was a significant decrease in the prevalence of albuminuria (38.9 to 18.7%, p-for-trend<0.001), but no change in the prevalence of reduced eGFR (7.5 to 9.9%, p-for-trend=0.30), retinopathy (1988-1994 to 1999-2008 only; 13.2 to 12.1%, p-for-trend=0.86), or self-reported cardiovascular disease (19.0 to 16.5%, p-for-trend=0.64). …”

Expression of Sox2, Sox10, Gata3, Prox1 and Peripherin during primary auditory neuron development and maturation. by Koji Nishimura (2077804)

“…At E10.5, Sox10 was downregulated as neuroblasts delaminated from the otocyst. …”

Evaluation of emerging NASH therapies: the impact of treatment efficacy profiles on long-term health outcomes: Supplementary materials by William L Herring (14039541)

“…The fibrosis worsening profile reduced predicted 10-year LRC rates (F1:</p> <p>1.9%; F2: 6.5%; F3: 19.1%; F4/CC: 55.0%) more than the resolution and fibrosis improvement profiles</p> <p>(F1: 2.6%/2.6%; F2: 8.5%/8.3%; F3: 23.3%/23.0%; F4/CC: NA/59.0%). …”

Secondary metabolites from <i>Gentiana cruciata</i> L. and their anti-inflammatory and analgesic activities by Rima Konya (14075753)

“…<p>A previously unreported secoiridoid glycoside, cruciatoside (<b>1</b>) was isolated from the aerial parts of <i>Gentiana cruciata</i> L. along with ten known compounds eustomoside (<b>2</b>), eustomorusside (<b>3</b>), gentiopicroside (<b>4</b>), 6'-<i>O</i>-β-D-glucopyranosyl gentiopicroside (<b>5</b>), loganic acid (<b>6</b>), isoorientin (<b>7</b>), isovitexin (<b>8</b>), isovitexin 2''<i>-(E)-</i>ferulate (<b>9</b>), mangiferin (<b>10</b>), and 2-methyl-inositol (<b>11</b>). …”

MPs^PPARα+/+-induced EPC differentiation and <i>in vitro</i> angiogenesis of mature ECs involve NF-κB pathway activation. by Tarek Benameur (196206)

“…<p>(<b>A</b>) Western blot showing that MPs^PPARα+/+ induced I-κB phosphorylation on activator sites (Ser32/36) in EPCs, indicating that NF-κB pathway is activated. …”

DNMT1-mediated demethylation of lncRNA MEG3 promoter suppressed breast cancer progression by repressing Notch1 signaling pathway by Tingting Pan (4735617)

“…Functionally, treatment of breast cancer cells with the DNA methylation inhibitor 5-AzadC as well as silencing of DNA methyltransferase-1 (DNMT1) could decrease the abnormal hypermethylation of the MEG3 promoter, reverse MEG3 expression, inhibit cell proliferation and promote cell apoptosis. …”

Identification of Differentially-Expressed Genes Associated with Pistil Abortion in Japanese Apricot by Genome-Wide Transcriptional Analysis by Ting Shi (3955)

“…<div><p>The phenomenon of pistil abortion widely occurs in Japanese apricot, and imperfect flowers with pistil abortion seriously decrease the yield in production. Although transcriptome analyses have been extensively studied in the past, a systematic study of differential gene expression has not been performed in Japanese apricot. …”

Evolutionary dynamics of iPD-population consisting of two types of players: With WSLS and AllD strategies. by Anton M. Unakafov (5706560)

“…<p>(A) Initially, both types have the same frequency, but after 40 generations the fraction of WSLS-players <i>x</i>₁(<i>t</i>) converges to 0 for probabilities to see partner’s choice <i>p</i>_see = 0.0, 0.2 and to 1 for <i>p</i>_see = 0.4, 0.5. …”

Effect of Vitrification on the MicroRNA Transcriptome in Mouse Blastocysts by Xueming Zhao (400630)

“…Of these, the expression levels of five miRNAs differed significantly: in the vitrified blastocysts, four miRNAs (mmu-miR-199a-5p, mmu-miR-329-3p, mmu-miR-136-5p and mmu-miR-16-1-3p) were upregulated, and one (mmu-miR-212-3p) was downregulated. …”

FDG PET parameters and survival curves. by Julien Ganem (7490378)

“…<p>Survival curves using the Kaplan-Meier method. <b>(a)</b> PFS was longer for patients with low TLG₂ (HR = 2.8, 95%CI 1.3–5.9, p< 0.01). …”

Loss of FHL2 reduces intestinal polyp multiplicity. by Charlotte Labalette (365229)

“…<p>(A) Representative images of intestines from 11-month-old <i>Apc^Δ14/+FHL2^+/+</i> and <i>Apc^Δ14/+FHL2^−/−</i> mouse. …”

Comparison of two physiotherapy treatments in reducing pain and increasing functional autonomy of elderly patients with gonarthrosis by Stela Freitas Raymundo (12817830)

“…Similarly, there was significant decrease (p<0.001) in the level of pain in both EG1 (Δ=5.09) and EG2 (Δ=7.1). …”

Methylation profiling in control and Tet tcKO retinas. Related to Fig 6. by Ismael Hernández-Núñez (10128242)

“…<p><b>(A)</b> Graphic displaying results of WGBS and bACE-seq to distinguish 5mC and 5hmC marks. …”

Advanced assessment of ductile fracture in steel by X-ray computed tomography by Fabien Léonard (463224)

Manager's Discretionary Power and Comparability of Financial Reports: An Analysis of the Regulatory Transition Process in Brazilian Accounting by Alex Mussoi Ribeiro (12830273)

The proposed mechanism whereby PPi protects against early electrical failure in the course of LDVF. by Junko Shibayama (387144)

Preprocessing of sequencing data. by Benjamín Sigurgeirsson (535869)

“…<p>The barplot shows how many reads survive through each of the steps of the preprocessing pipline (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0091851#s2" target="_blank">Methods</a>). …”

Transition matrices for HMM models. by Mark J. Panaggio (10291238)

“…Values indicate the probability of transitioning between source and target classes at each time step (2 hour window). These values were obtained by averaging over 10 models resulting from the 10 folds used in cross-validation. …”