Nutritional Control of DNA Replication Initiation through the Proteolysis and Regulated Translation of DnaA by David J. Leslie (764323)

“…Instead, we demonstrate that decreased nutrient availability downregulates <i>dnaA</i> translation by a mechanism involving the 5' untranslated leader region of the <i>dnaA</i> transcript; Lon-dependent proteolysis of DnaA then outpaces synthesis, leading to the elimination of DnaA and the arrest of DNA replication. …”

A Family of Octahedral Rhenium Cluster Complexes [Re₆Q₈(H₂O)<i>_n</i>(OH)₆_-<i>_n<... by Konstantin A. Brylev (1379436)

An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals by Dominique Detaille (3768979)

“…<div><p>Findings</p><p>Here, we demonstrate that OP2113 (5-(4-Methoxyphenyl)-3H-1,2-dithiole-3-thione, CAS 532-11-6), synthesized and used as a drug since 1696, does not act as an unspecific antioxidant molecule (i.e., as a radical scavenger) but unexpectedly decreases mitochondrial reactive oxygen species (ROS/H₂O₂) production by acting as a specific inhibitor of ROS production at the I_Q site of complex I of the mitochondrial respiratory chain. …”

Decreased levels of soluble amyloid β-protein precursor and β-amyloid protein but increases of intrathecal axonal degradation products and TGF-β in patients with cerebral lupus by Estelle Trysberg (58614)

DataSheet_1_Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life.docx by Hanqi Lu (8563149)

“…</p>Methods and Results<p>Three-week-old mice were treated with AZT (50 mg/kg/day) via drinking water for two weeks and then were fed a CRP diet (1% CRP extract) for four weeks and an HFD for five weeks. …”

Table_1_Comparison of the First and Second Wave of Infections by SARS-CoV-2: A Retrospective and Longitudinal Study From a Primary Health Care Center in Santiago of Chile.docx by Claudio Acuña-Castillo (512379)

“…In addition, we observed that infections in the second wave were mainly in young patients with reduced comorbidities. The population with a complete vaccination schedule shows a decrease in the duration of symptoms related to the disease, and patients with more comorbidities tend to develop severe illness. …”

IQGAP1 is a protein that plays a critical role in regulating the level of apoptosis in endothelial cells. by Shaojun Huang (12489901)

“…<p>(A) The Annexin V–FITC/propidium iodide (PI) assay results indicate that Si-IQGAP1 can slightly decrease the apoptosis rate of normal cells, whereas knocking down IQGAP1 in PA-induced cells (PA + Si-IQGAP1) can significantly reduce the apoptosis rate. …”

<i>Arid1a</i>^<i>d/d</i> mice exhibited an altered decidualization. by Tae Hoon Kim (128536)

“…The uterine weight ratio was significantly decreased in <i>Arid1a</i>^<i>d/d</i> mice as compared to <i>Arid1a</i>^<i>f/f</i> (C) Histology of control and stimulated horn in <i>Arid1a</i>^<i>f/f</i> (a and c) and <i>Arid1a</i>^<i>d/d</i> mice (b and d) at day 5, respectively (D) The expression of decidualization marker genes, <i>Bmp2</i>, <i>Fst</i> and <i>Fkbp5</i> was measured in the uteri of control and stimulated horn. …”

Synthesis, Ion Aggregation, Alkyl Bonding Modes, and Dynamics of 14-Electron Metallocenium Ion Pairs [(SBI)MCH₂SiMe₃⁺···X^-] (M = Zr, Hf)... by Fuquan Song (2690335)

“…Whereas in the MeB(C₆F₅)₃^- complexes the alkyl ligand points away from the metal and tight anion coordination forms the familiar inner-sphere ion pair, in the B(C₆F₅)₄^- salts the alkyl ligand adopts a conformation that enables agostic bonding to a γ-CH₃ group. …”

Cardiac percentage engraftment 24h post-injection. by Kristine Yee (668076)

Data Sheet 1_A cost-reducing reimbursement programme? Effects of value-based reimbursement on healthcare costs.docx by Thérèse Eriksson (20413838)

The hybrid incompatibility proteins HMR and LHR interact in a defined HMR/LHR complex. by Andrea Lukacs (3752956)

Closed loop stimulation (CLS) and driving stimulation (DSt) protocols. by Muhammad Mushtaq (788834)

Data_Sheet_1_Parental perceptions and the 5C psychological antecedents of COVID-19 vaccination during the first month of omicron variant surge: A large-scale cross-sectional survey... by Shuliweeh Alenezi (11671658)

“…We utilized the validated 5C Scale, which evaluates five psychological factors influencing vaccination intention and behavior: confidence, complacency, constraints, calculation, and collective responsibility.…”

Vaccination with Pneumovax^®23 does not generate a detectable memory response after 90 days. by Alena Roth (2586994)

Segmentation of cerebral subcortical deep gray matter with FSL-FIRST and FreeSurfer pipelines. by Renxin Chu (5169857)

Video_2_Resveratrol enhances A1 and hinders A2A adenosine receptors signaling in both HeLa and SH-SY5Y cells: Potential mechanism of its antitumoral action.mp4 by Sonia Muñoz-López (11369454)

“…Interestingly, these effects were almost identical in HeLa and SH-SY5Y cells suggesting that resveratrol enhances A₁ and hinders A_2A adenosine receptors signaling as part of a potential mechanism of antitumoral action.…”

Video_1_Resveratrol enhances A1 and hinders A2A adenosine receptors signaling in both HeLa and SH-SY5Y cells: Potential mechanism of its antitumoral action.mp4 by Sonia Muñoz-López (11369454)

“…Interestingly, these effects were almost identical in HeLa and SH-SY5Y cells suggesting that resveratrol enhances A₁ and hinders A_2A adenosine receptors signaling as part of a potential mechanism of antitumoral action.…”

<b>Ensemble learning model identifies </b><b>adaptation classification and turning points</b><b> of river microbial communities in response to heatwaves</b> by Qian Qu (14198684)

“…If emissions of particulate matter with sizes not more than 2.5 μm (PM2.5, an indicator of human activities) increase by 2-fold, the number of global rivers associated with the fast stress adaptation type will decrease by ~13.7% after heatwave disturbances. …”

A 48-year-old man with Moyamoya disease. by Soo Buem Cho (4576561)

“…(F). On a spectral plot from a MonoE image at 40 keV, active extravasation reveals a gradual decrease in HU values with a steep slope (ROI 3), suggesting iodine. …”