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19941
The change in mean annual densities of Amakihi at mid-elevation due to the translocation of disease-resistant Amakihi as a function of larval carrying capacity and density of infec...
Published 2013“…The other climate scenarios are derived from this scenario by increasing or decreasing the daily temperatures and rainfall. The mean annual temperatures and average yearly amounts of rainfall for these scenarios are 15.5°C and 3000 mm (t−), 18.5°C and 3000 mm (t+), 17°C and 2000 mm (r−) and 17°C and 4000 mm (r+). …”
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19942
Decreases in white matter integrity in t(1;11) translocation carriers (n = 7) versus non-carriers (n = 13) and in patients (n = 34) versus controls (n = 33).
Published 2015“…To aid visualization the results (pfwe < 0.05) are thickened using the “tbss-fill” command. Statistics for FA decreases in the patient group versus controls for these peaks; cluster 1: p = 0.023 at [-3, 28, 6; left genu of corpus callosum], cluster 2: p = 0.032 at [29, 26, 15; right fronto-occipital fasciculus], cluster 3: p = 0.012 at [11, 26, 14; right genu of corpus callosum], cluster 4: p = 0.033 at [20, 25, 0; right acoustic radiation], and cluster 5: p = 0.031 at [28, -24, -8; right fornix] i.e. for clusters 1–5 respectively, see, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130900#pone.0130900.t002" target="_blank">Table 2</a>).…”
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19943
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19944
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19945
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19946
Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling
Published 2019“…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …”
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19947
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19948
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19949
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19950
Influence of chemical components of PVAC during storage of RBC.
Published 2019“…In <b>(b)</b> values after 1 month (end of storage) are shown: PVA at 100 μg/mL increased hemolysis while PVAC at 2.5 mg/mL, 500 and, 100 μg/mL decreased the levels of hemolysis compared to the control.…”
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19951
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19952
Caffeine effects on embryonic heart function at E9.5 and E12.5 under normoxic and hypoxic (2% O<sub>2</sub>) conditions.
Published 2013“…<p>In room air, E9.5 embryos (A) and E12.5 hearts (B) were treated with 200 µM caffeine (E9.5, n = 20; E12.5, n = 17) or vehicle (E9.5, n = 24; E12.5, n = 17) at 15 min, as indicated by arrows. …”
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19953
Hepatic IRE1α/XBP1 pathway of the UPR is decreased in pediatric cholestatic liver disease (pCLD) samples compared to pediatric normal (pNormal) livers.
Published 2022“…<p>A) Hepatic gene expression of IRE1α, XBP1s and downstream targets EDEM1 and ERdj4 were measured via qPCR. pCLD livers (n = 10) had decreases in IRE1α, XBP1, EDEM1 and ERdj4 expression compared to pNormal livers (n = 9). …”
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19954
Histamine 1 Receptor Blockade Enhances Eosinophil-Mediated Clearance of Adult Filarial Worms
Published 2015“…Although fexofenadine-treated mice had decreased antigen-specific IgE levels as well as lower splenocyte IL-5 and IFNγ production, they exhibited a greater than fourfold rise in eosinophil numbers at the tissue site where adult <i>L</i>. …”
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19955
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19956
Image_1_Loss of the Essential Autophagy Regulators FIP200 or Atg5 Leads to Distinct Effects on Focal Adhesion Composition and Organization.TIF
Published 2020“…We provide evidence suggesting the primary autophagy regulators Atg5 and FIP200 both play a role in cell motility and extracellular matrix adhesion. …”
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19957
Image_2_Loss of the Essential Autophagy Regulators FIP200 or Atg5 Leads to Distinct Effects on Focal Adhesion Composition and Organization.TIF
Published 2020“…We provide evidence suggesting the primary autophagy regulators Atg5 and FIP200 both play a role in cell motility and extracellular matrix adhesion. …”
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19958
Programmed Release METTL3-14 Inhibitor Microneedle Protects Myocardial Function by Reducing Drp1 m6A Modification-Mediated Mitochondrial Fission
Published 2023“…RIP assay and mechanistic investigation confirmed that METTL3 inhibition reduced the translation efficiency of Drp1 mRNA by 5′UTR m6A modification, thus decreasing the Drp1 protein level and mitochondrial fragment after hypoxic-ischemic injury. …”
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19959
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19960