An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals by Dominique Detaille (3768979)

“…<div><p>Findings</p><p>Here, we demonstrate that OP2113 (5-(4-Methoxyphenyl)-3H-1,2-dithiole-3-thione, CAS 532-11-6), synthesized and used as a drug since 1696, does not act as an unspecific antioxidant molecule (i.e., as a radical scavenger) but unexpectedly decreases mitochondrial reactive oxygen species (ROS/H₂O₂) production by acting as a specific inhibitor of ROS production at the I_Q site of complex I of the mitochondrial respiratory chain. …”

Decreased levels of soluble amyloid β-protein precursor and β-amyloid protein but increases of intrathecal axonal degradation products and TGF-β in patients with cerebral lupus by Estelle Trysberg (58614)

DataSheet_1_Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life.docx by Hanqi Lu (8563149)

“…</p>Methods and Results<p>Three-week-old mice were treated with AZT (50 mg/kg/day) via drinking water for two weeks and then were fed a CRP diet (1% CRP extract) for four weeks and an HFD for five weeks. …”

Table_1_Comparison of the First and Second Wave of Infections by SARS-CoV-2: A Retrospective and Longitudinal Study From a Primary Health Care Center in Santiago of Chile.docx by Claudio Acuña-Castillo (512379)

“…In addition, we observed that infections in the second wave were mainly in young patients with reduced comorbidities. The population with a complete vaccination schedule shows a decrease in the duration of symptoms related to the disease, and patients with more comorbidities tend to develop severe illness. …”

IQGAP1 is a protein that plays a critical role in regulating the level of apoptosis in endothelial cells. by Shaojun Huang (12489901)

“…<p>(A) The Annexin V–FITC/propidium iodide (PI) assay results indicate that Si-IQGAP1 can slightly decrease the apoptosis rate of normal cells, whereas knocking down IQGAP1 in PA-induced cells (PA + Si-IQGAP1) can significantly reduce the apoptosis rate. …”

Synthesis, Ion Aggregation, Alkyl Bonding Modes, and Dynamics of 14-Electron Metallocenium Ion Pairs [(SBI)MCH₂SiMe₃⁺···X^-] (M = Zr, Hf)... by Fuquan Song (2690335)

“…Whereas in the MeB(C₆F₅)₃^- complexes the alkyl ligand points away from the metal and tight anion coordination forms the familiar inner-sphere ion pair, in the B(C₆F₅)₄^- salts the alkyl ligand adopts a conformation that enables agostic bonding to a γ-CH₃ group. …”

Cardiac percentage engraftment 24h post-injection. by Kristine Yee (668076)

Data Sheet 1_A cost-reducing reimbursement programme? Effects of value-based reimbursement on healthcare costs.docx by Thérèse Eriksson (20413838)

The hybrid incompatibility proteins HMR and LHR interact in a defined HMR/LHR complex. by Andrea Lukacs (3752956)

Closed loop stimulation (CLS) and driving stimulation (DSt) protocols. by Muhammad Mushtaq (788834)

Data_Sheet_1_Parental perceptions and the 5C psychological antecedents of COVID-19 vaccination during the first month of omicron variant surge: A large-scale cross-sectional survey... by Shuliweeh Alenezi (11671658)

“…We utilized the validated 5C Scale, which evaluates five psychological factors influencing vaccination intention and behavior: confidence, complacency, constraints, calculation, and collective responsibility.…”

Vaccination with Pneumovax^®23 does not generate a detectable memory response after 90 days. by Alena Roth (2586994)

Segmentation of cerebral subcortical deep gray matter with FSL-FIRST and FreeSurfer pipelines. by Renxin Chu (5169857)

Video_2_Resveratrol enhances A1 and hinders A2A adenosine receptors signaling in both HeLa and SH-SY5Y cells: Potential mechanism of its antitumoral action.mp4 by Sonia Muñoz-López (11369454)

“…Interestingly, these effects were almost identical in HeLa and SH-SY5Y cells suggesting that resveratrol enhances A₁ and hinders A_2A adenosine receptors signaling as part of a potential mechanism of antitumoral action.…”

Video_1_Resveratrol enhances A1 and hinders A2A adenosine receptors signaling in both HeLa and SH-SY5Y cells: Potential mechanism of its antitumoral action.mp4 by Sonia Muñoz-López (11369454)

“…Interestingly, these effects were almost identical in HeLa and SH-SY5Y cells suggesting that resveratrol enhances A₁ and hinders A_2A adenosine receptors signaling as part of a potential mechanism of antitumoral action.…”

<b>Ensemble learning model identifies </b><b>adaptation classification and turning points</b><b> of river microbial communities in response to heatwaves</b> by Qian Qu (14198684)

“…If emissions of particulate matter with sizes not more than 2.5 μm (PM2.5, an indicator of human activities) increase by 2-fold, the number of global rivers associated with the fast stress adaptation type will decrease by ~13.7% after heatwave disturbances. …”

A 48-year-old man with Moyamoya disease. by Soo Buem Cho (4576561)

“…(F). On a spectral plot from a MonoE image at 40 keV, active extravasation reveals a gradual decrease in HU values with a steep slope (ROI 3), suggesting iodine. …”

Nutritional Control of DNA Replication Initiation through the Proteolysis and Regulated Translation of DnaA by David J. Leslie (764323)

“…Instead, we demonstrate that decreased nutrient availability downregulates <i>dnaA</i> translation by a mechanism involving the 5' untranslated leader region of the <i>dnaA</i> transcript; Lon-dependent proteolysis of DnaA then outpaces synthesis, leading to the elimination of DnaA and the arrest of DNA replication. …”

Both T1 and T2 LCLs can be separated into 11 separate clusters in scRNA-seq analysis. by Jillian A. Bristol (5566289)

Molecular and cellular defects in <i>Sr/+;Nr/+</i> SCO development at 12.5 dpc and 14.5 dpc. by Kristie Lee (186289)

“…<p><b>A,B:</b> Saggital section of 12.5 dpc wild type (A) and <i>Sr/+;Nr/+</i> (B) SCO region showing immuno-positive BrdU cells. …”