Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5‑LOX Inhibitor that Limits Inflammation by Konstantin Neukirch (11153961)

“…Endogenous long-chain metabolites of vitamin E (LCMs) mediate immune functions by targeting 5-lipoxygenase (5-LOX) and increasing the systemic concentrations of resolvin E3, a specialized proresolving lipid mediator. …”

Nonequilibrium Arrhythmic States and Transitions in a Mathematical Model for Diffuse Fibrosis in Human Cardiac Tissue by Rupamanjari Majumder (128411)

“…Our study of a single myocyte-fibroblast (MF) composite, with a single myocyte coupled to fibroblasts via a gap-junctional conductance , reveals five qualitatively different responses for this composite. …”

Image_5_10-Hydroxydec-2-Enoic Acid Reduces Hydroxyl Free Radical-Induced Damage to Vascular Smooth Muscle Cells by Rescuing Protein and Energy Metabolism.TIF by Pei Fan (404125)

“…In this study, we found that the •OH scavenging rate by 10-HDA (2%, g/ml) was more than 20%, which was achieved through multiple-step oxidization of the –OH group and C=C bond of 10-HDA. …”

HBV RNA could be methylated by NSUN2 <i>in vitro</i>. by Jiangpeng Feng (9287738)

OPTN degrades GSK3β via activating LC3-mediated autophagy. by Xiao Chen Shi (8611887)

Relationships between each parameter relative change and stent wire mesh density. by Shunsuke Masuda (12859231)

Changes in biomarkers with age among past-prime individuals (> 35 years old) in a mixed-longitudinal sample. by Nicole Thompson González (9257300)

Platelets were inhibited by PFC administration and activated in response to LPS. by Heather F. Pidcoke (9023789)

MicroRNA-139-5p acts as a suppressor gene for depression by targeting nuclear receptor subfamily 3, group C, member 1 by Bing Su (51332)

“…Moreover, as a potential target for miR-139-5p, NR3C1 level was reduced by miR-139-5p mimic. …”

DataSheet_1_cheA, cheB, cheR, cheV, and cheY Are Involved in Regulating the Adhesion of Vibrio harveyi.docx by Xiaojin Xu (6661580)

“…The genes responsible for chemotaxis (cheA, cheB, cheR, cheV, and cheY), which are also crucial for adhesion, were identified and silenced via RNAi. …”

Image_5_Cardioprotective Effects and Possible Mechanisms of Luteolin for Myocardial Ischemia-Reperfusion Injury: A Systematic Review and Meta-Analysis of Preclinical Evidence.TIF by Qinyuan Pan (11589910)

Sequence alignments of HBV from high-throughput bisulfite sequencing or different HBV genotypes. by Jiangpeng Feng (9287738)

Potential interplay between Aβ oligomers, Ca²⁺, and a target cell in the initial stages of Alzheimer's disease. by Anna Itkin (354170)

“…These three steps might form an inimical cycle leading to increases in both cytosolic calcium and Aβ oligomer concentrations. (4) Aβ oligomers disrupt intracellular membranes, leading to apoptosis <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018250#pone.0018250-Kawahara1" target="_blank">[34]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018250#pone.0018250-Arispe1" target="_blank">[41]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018250#pone.0018250-Arispe2" target="_blank">[64]</a>. (5) Extracellular calcium concentration ([Ca²⁺]_e) promotes oligomerization of extracellular Aβ. (6) Oligomers form nonspecific pores in the plasma membrane, disturbing cellular integrity and leading to apoptosis <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018250#pone.0018250-Bucciantini1" target="_blank">[65]</a>. (7) Aβ oligomers can interact and impair calcium channels at the membrane surface, opening calcium importers and blocking calcium exporters such as the voltage-dependent calcium channel <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018250#pone.0018250-Rovira1" target="_blank">[66]</a>. …”

Transmission electron micrographs of expelled <i>Symbiodinium</i> from <i>Acropora selago</i> on the first day at 27°C. by Lisa Fujise (672628)

Validation of ALDH1A3 as target of miR-187. by Irene Casanova-Salas (738137)

“…<p>A) RNA22 predicted mRNA-miRNA heteroduplexes. RNA22 v1.0 software predicted three different miR-187 binding sites within ALDH1A3 mRNA sequence. …”

Fig 2 - by Karolina Pawlak (13813008)

Table_5_High-throughput screening of the effects of 90 xenobiotics on the simplified human gut microbiota model (SIHUMIx): a metaproteomic and metabolomic study.XLSX by Victor Castañeda-Monsalve (17989807)

“…Several food additives had significant effects on the relative abundances of bacterial species; for example, acid orange 7 and saccharin led to a 75% decrease in Clostridium butyricum, with saccharin causing an additional 2.5-fold increase in E. coli compared to the control. …”

Table_2_Oral Zinc Sulfate for Prevention and Treatment of Chemotherapy-Induced Oral Mucositis: A Meta-Analysis of Five Randomized Controlled Trials.DOC by Xu Tian (179192)

“…We included five eligible studies involving 352 patients. Meta-analysis based on limited data revealed that oral zinc sulfate failed to decrease the incidence of chemotherapy-induced oral mucositis (RR [relative risk] = 0.52, 95% CI [confidence interval] = 0.17–1.64) as well as relieve chemotherapy-induced oral mucositits grade (RR = 0.62, 95% CI = 0.11–3.56; RR = 0.70, 95% CI = 0.29–1.71). …”

Image_5_Vancomycin-induced gut microbial dysbiosis alters enteric neuron–macrophage interactions during a critical period of postnatal development.jpeg by Ellen Merrick Schill (17135947)

Table_1_Oral Zinc Sulfate for Prevention and Treatment of Chemotherapy-Induced Oral Mucositis: A Meta-Analysis of Five Randomized Controlled Trials.DOCX by Xu Tian (179192)

“…We included five eligible studies involving 352 patients. Meta-analysis based on limited data revealed that oral zinc sulfate failed to decrease the incidence of chemotherapy-induced oral mucositis (RR [relative risk] = 0.52, 95% CI [confidence interval] = 0.17–1.64) as well as relieve chemotherapy-induced oral mucositits grade (RR = 0.62, 95% CI = 0.11–3.56; RR = 0.70, 95% CI = 0.29–1.71). …”