RNAseq analysis of IAV-infected AECs and AMs with and without TrkA inhibition. by Vikram Verma (13822961)

320-row CT transcatheter aortic valve replacement planning with a single reduced contrast media bolus injection by Daddy Mata-Mbemba (5746847)

“…<div><p>Objective</p><p>To reduce the iodine load required for CT Transcatheter Aortic Valve Replacement (TAVR) planning on a 320-row scanner by acquiring the two CT TAVR steps (ECG-gated aortic root CTA and non-gated aorto-ilio-femoral CTA) within a single contrast media bolus injection.…”

Effects of RcsB, LrhA, RtsB and SlyA on transcription of P1<i>_flhDC</i> and P5<i>_flhDC</i>. by Chakib Mouslim (531364)

“…Luciferase activity of P5⁻<i>_fhlDC-luxCDBAE-</i>Pwt<i>_flhDCflhD</i>⁺<i>C</i>⁺ transcriptional fusion (P1-expressed) was investigated in five genetic backgrounds: wild-type (TH18895), Δ<i>rcsB</i>::<i>tetRA</i> (TH20237), <i>rtsB</i>::T-POP (TH19976), Δ<i>lrhA</i>::<i>tetRA</i> (TH19974), <i>slyA</i>::T-POP (TH19975). …”

(A) Activity of SOD under B stress; (B) Activity of POD under B stress; (C) Activity of CAT under B stress; (D) Activity of APX under B stress; (E) Content of MDA under B stress ac... by Qiang Li (8118)

Exhumation and deformation history of the lower crustal section of the Valstrona di Omegna in the Ivrea Zone, southern Alps by S. Siegesmund (2845832)

Image_4_Substrate Specificity of Acyltransferase Domains for Efficient Transfer of Acyl Groups.TIF by Jie-Jie Shen (5600129)

“…In Streptomycestsukubaensis YN06, we found that AT4_FkbB [an AT in the fourth module of tacrolimus (FK506) PKS] transferred both allylmalonyl (allmal) and emthylmalonyl (ethmal) units to ACPs, which was supposed responsible for the production of both FK506 and its analog FK520, respectively. Mutations of five residues in AT4_FkbB (Q119A, L185I-V186D-V187T, and F203L) caused decreased efficiency of allmal transfer, but a higher ratio of ethmal transfer, supposedly due to less nucleophilic attacks between Ser599 in the active site of AT4_FkbB and the carbonyl carbon in the allmal unit, as observed from molecular dynamics simulations. …”

Image_3_Substrate Specificity of Acyltransferase Domains for Efficient Transfer of Acyl Groups.TIF by Jie-Jie Shen (5600129)

“…In Streptomycestsukubaensis YN06, we found that AT4_FkbB [an AT in the fourth module of tacrolimus (FK506) PKS] transferred both allylmalonyl (allmal) and emthylmalonyl (ethmal) units to ACPs, which was supposed responsible for the production of both FK506 and its analog FK520, respectively. Mutations of five residues in AT4_FkbB (Q119A, L185I-V186D-V187T, and F203L) caused decreased efficiency of allmal transfer, but a higher ratio of ethmal transfer, supposedly due to less nucleophilic attacks between Ser599 in the active site of AT4_FkbB and the carbonyl carbon in the allmal unit, as observed from molecular dynamics simulations. …”

Image_2_Substrate Specificity of Acyltransferase Domains for Efficient Transfer of Acyl Groups.TIF by Jie-Jie Shen (5600129)

“…In Streptomycestsukubaensis YN06, we found that AT4_FkbB [an AT in the fourth module of tacrolimus (FK506) PKS] transferred both allylmalonyl (allmal) and emthylmalonyl (ethmal) units to ACPs, which was supposed responsible for the production of both FK506 and its analog FK520, respectively. Mutations of five residues in AT4_FkbB (Q119A, L185I-V186D-V187T, and F203L) caused decreased efficiency of allmal transfer, but a higher ratio of ethmal transfer, supposedly due to less nucleophilic attacks between Ser599 in the active site of AT4_FkbB and the carbonyl carbon in the allmal unit, as observed from molecular dynamics simulations. …”

Image_1_Substrate Specificity of Acyltransferase Domains for Efficient Transfer of Acyl Groups.TIF by Jie-Jie Shen (5600129)

“…In Streptomycestsukubaensis YN06, we found that AT4_FkbB [an AT in the fourth module of tacrolimus (FK506) PKS] transferred both allylmalonyl (allmal) and emthylmalonyl (ethmal) units to ACPs, which was supposed responsible for the production of both FK506 and its analog FK520, respectively. Mutations of five residues in AT4_FkbB (Q119A, L185I-V186D-V187T, and F203L) caused decreased efficiency of allmal transfer, but a higher ratio of ethmal transfer, supposedly due to less nucleophilic attacks between Ser599 in the active site of AT4_FkbB and the carbonyl carbon in the allmal unit, as observed from molecular dynamics simulations. …”

Table_1_Substrate Specificity of Acyltransferase Domains for Efficient Transfer of Acyl Groups.DOC by Jie-Jie Shen (5600129)

“…In Streptomycestsukubaensis YN06, we found that AT4_FkbB [an AT in the fourth module of tacrolimus (FK506) PKS] transferred both allylmalonyl (allmal) and emthylmalonyl (ethmal) units to ACPs, which was supposed responsible for the production of both FK506 and its analog FK520, respectively. Mutations of five residues in AT4_FkbB (Q119A, L185I-V186D-V187T, and F203L) caused decreased efficiency of allmal transfer, but a higher ratio of ethmal transfer, supposedly due to less nucleophilic attacks between Ser599 in the active site of AT4_FkbB and the carbonyl carbon in the allmal unit, as observed from molecular dynamics simulations. …”

Generation of mice deficient for Dyrk1a in the glutamatergic neurons. by Véronique Brault (160595)

“…Expression of DYRK1A was detected in the cytoplasm of the neurons of the control (Ctrl) and a net decrease of expression was observed in <i>Dyrk1a</i>^<i>C/C</i> neurons as visible in the high-magnification images of the cortex (1), Cornus Ammonis 1(CA1, 2), Cornus Ammonis 3(CA3, 3) and Dentate Gyrus (DG, 4) (white arrows point at neurons with little or no DYRK1A signal). …”

ΔRMSF of RBD-S477N bound with ACE2 and RBD-T478I bound with ACE2. by George Rucker (17101889)

Data_Sheet_1_Host Factor Nucleoporin 93 Is Involved in the Nuclear Export of Influenza Virus RNA.DOCX by Yuri Furusawa (5546819)

Description of biomarkers, gene, primer sequences and NCBI accession numbers. by Conceição S. Martins (468492)

Effect of topical application of GSNO/HPMC formulation on histopathologic score of rat maxillae. by Conceição S. Martins (468492)

Effect of HPMC/GSNO on the nitrite/nitrate (NOX) levels in experimental periodontitis in rats. by Conceição S. Martins (468492)

Effect of topical application of HPMC/GSNO solutions on the plasma bone alkaline phosphatase (BAP) in experimental periodontitis in rats. by Conceição S. Martins (468492)

Quantification of iNOS, RANK, TRAP and nitrotyrosine immunostainning in periodontal tissue of rats submitted to experimental periodontitis. by Conceição S. Martins (468492)

Effect of topical application of HPMC/GSNO solutions on alveolar bone loss in experimental periodontitis. by Conceição S. Martins (468492)

Structure–Activity Relationships and Discovery of (<i>S</i>)‑5‑(<i>tert</i>-Butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1,2,5,6-tetrahydropyrido[2′,1′:2,3]imidazo[4,5‑<i>h</i>]quin... by Dimitar Gotchev (1893928)

“…Optimization of a novel series of PAPD5/7 inhibitors that decrease HBsAg levels led to the tetracyclic 2-pyridone <b>AB-161</b>, which was similarly potent to <b>AB-452</b> <i>in vitro</i> and <i>in vivo</i> but showed dramatically higher rodent liver-to-plasma ratios. …”