Design, Synthesis, and Biological Evaluation of New PDE4 Inhibitors for the Treatment of Pressure Ulcers by Xudong Qian (13182676)

Data_Sheet_1_WSV056 Inhibits Shrimp Nitric Oxide Synthase Activity by Downregulating Litopenaeus vannamei Sepiapterin Reductase to Promote White Spot Syndrome Virus Replication.doc... by Wei Wang (17594)

“…L. vannamei challenged with WSSV revealed a significant decrease in LvSpr transcription and Spr activity in hemocytes. …”

Can Forest Management Practices Counteract Species Loss Arising from Increasing European Demand for Forest Biomass under Climate Mitigation Scenarios? by Francesca Rosa (3509216)

“…This outcome stems from a projected increase in EU forest biomass imports, partially from biodiversity-vulnerable regions to compensate for a decrease in domestic harvest. …”

Protein Biomarkers and Risk Scores in Pulmonary Arterial Hypertension Associated with Ventricular Septal Defect: Integration of Multi-Omics and Validation by Chao Yuan (408257)

“…Proteomics (iTRAQ) identified 107 differential proteins (DPs) between patients with/without PAH including significantly increased ADIPO, DBH, ANPEP, TRF1, GP1BA and decreased GNAS in VSD-PAH. Metabolomics discovered 191 differential metabolites between patients with/without PAH including elevation of 5-HT, taurine, creatine, sarcosine, and 2-oxobutanoate and decrease of vanillylmandelic acid, 3,4-dihydroxymandelate, 15-Keto-PGF2, fructose-6-phosphate , L-glutamine, dehydroascorbate, hydroxypyruvate, threonine, L-cystine, and 1-aminocyclopropane-1-carboxylate. …”

Bunched, the homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth-2 by Silvia Gluderer (70476)

“…The effect on clone area is slightly more pronounced than the effect on cell number, indicating a decrease in size of mutant cells. (F) The average area of the mutant cells is 5% () and 10% () smaller than the average area of the wild-type sister cells.…”

Amplex Red H₂O₂ measurements in <i>E</i>. <i>faecalis</i>-fed worms. by Saida Benomar (561001)

“…<p>(A) PBO-1, but not PBO-4, is important for H₂O₂ production in response to <i>E</i>. …”

The acute exposure effects of inhaled nickel nanoparticles on murine endothelial progenitor cells by Eric N. Liberda (502920)

“…These results coincided with a decrease in the mRNA of receptors involved in EPC mobilization and homing. …”

Nest design as an adaptative tool to escape brood parasitism by Angela Moreras (12024272)

“…Redstarts seem to adopt nest design strategies to decrease brood parasitism risk, while cuckoos’ preference for certain aspects of redstart nest design may be shaped by a conflict between female laying success and chick eviction success. …”

Reduction of Alcian blue staining in <i>fam20b</i> and <i>xylt1</i> mutants is less severe than in <i>uxs1</i> mutants. by B. Frank Eames (208061)

“…Compared to wild-type Alcian blue staining, <i>fam20b^b1127</i> mutants had 50±3.0%, <i>xylt1^b1128</i> mutants had 57±2.0%, <i>fam20b^b1127;xylt1^b1128</i> double mutants had 39±2.6%, and <i>uxs1</i> mutants had 22±1.5%. G, Simplified pathway of PG synthesis, demonstrating that <i>uxs1</i> is upstream of both <i>xylt1</i>, which adds xylose to a serine (Ser) residue of the core protein, and also <i>fam20b</i>, which phosphorylates (P) xylose in the nascent GAG chain. …”

Sex Role Segregation and Mixing among Men Who Have Sex with Men: Implications for Biomedical HIV Prevention Interventions by Benjamin Armbruster (110448)

“…</p><p>Materials and Methods</p><p>We developed a deterministic compartmental model to predict HIV incidence among Indian MSM using data from 2003–2010. …”

Data_Sheet_1_Screening effects of HCN channel blockers on sleep/wake behavior in zebrafish.PDF by Fusun Doldur-Balli (3459110)

“…Results of interest included shorter latency to daytime sleep at 0.1 μM dose of Ivabradine (ANOVA, p: 0.02), moderate reduction in average activity at 30 μM dose of Zatebradine Hydrochloride (ANOVA, p: 0.024) in daytime, and increased nighttime sleep at 4.5 μM dose of ZD7288 (ANOVA, p: 0.036). Taken together, shorter latency to daytime sleep, decrease in daytime activity and increased nighttime sleep indicate that different HCN channel antagonists affected different parameters of sleep and activity.…”

Supplemental Figures 1-9 from Combined Targeting of the BRD4–NUT–p300 Axis in NUT Midline Carcinoma by Dual Selective Bromodomain Inhibitor, NEO2734 by Chevaun D. Morrison-Smith (15086536)

“…Supplemental Figure S2: Caspase-mediated apoptosis plays a minimal role in the activity of GNE-781, OTX015, or NEO2734. …”

Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery by Stephan G. Zech (1417117)

Multiaction Platinum(IV) Prodrug Containing Thymidylate Synthase Inhibitor and Metabolic Modifier against Triple-Negative Breast Cancer by Nafees Muhammad (5641151)

“…Cellular uptake and distribution studies reveal that <b>PFL</b> mainly accumulates in mitochondria. As a result, <b>PFL</b> disrupts the mitochondrial ultrastructure and induces significant alterations in the mitochondrial membrane potential, which further leads to an increase in production of reactive oxygen species (ROS) and a decrease in ATP synthesis in MDA-MB-231 TNBCs. …”

Mtb transmission model schematic. by Joshua Havumaki (607091)

“…The parameters are as follows, <i>μ</i> is the mortality rate, λ is the force of infection (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0293519#pone.0293519.e001" target="_blank">Eq 1</a> for details) which is modulated by <i>ω</i> to account for partial immunity among previously or currently infected individuals, <i>ϵ</i> is the rate of progression from early latent to active TB (rates of progression decrease as time since infection increases as represented in the <i>EL</i> sub-states panel), <i>τ</i> is the rate of progression from late latent to active TB, <i>κ</i> is the active TB mortality rate, <i>γ</i> is the rate of spontaneous recovery from active TB, <i>ATB</i> <i>treat</i> is the treatment rate of individuals in active TB, and finally <i>txd</i> is the duration of treatment. …”

Table_2_Comparison Analysis of Different DNA Extraction Methods on Suitability for Long-Read Metagenomic Nanopore Sequencing.docx by Lei Zhang (38117)

“…Compared with the control method, the enzymatic-based method increased the average length of microbial reads by a median of 2.1-fold [Inter Quartile Range (IQR), 1.7–2.5; maximum, 4.8) in 18 of the 20 samples and the mapped reads proportion of specific species by a median of 11.8-fold (Inter Quartile Range (IQR), 6.9–32.2; maximum, 79.27]. …”

Table 1_Exploring the effects of dietary methionine supplementation on European seabass mucosal immune responses against Tenacibaculum maritimum.docx by Inês Carvalho (59935)

“…However, after infection, fish fed higher methionine levels exhibited a dose-dependent decrease in the mRNA expression of some proinflammatory genes. …”

DataSheet_1_Long-term use of rituximab increases T cell count in MS patients.docx by Gunnar Sigfús Björnsson (19159402)

“…Long-term use of rituximab led to an increase in T cell count (p=0,0015) in patients receiving 3-8 doses of rituximab (1.5-8 years of treatment). The increase occurred in both CD4⁺ (p=0,0028) and CD8⁺ T cells (p=0,0015) and led to a decrease in the CD4/CD8 ratio (p=0,004). …”

Distinct Temperature Trends in the Uptake of Gaseous <i>n</i>‑Butylamine on Two Solid Diacids by Yixin Li (1540552)

“…In contrast, the uptake coefficients on GA increase from 0.11 ± 0.04 at 298 K to 0.25 ± 0.04 at 248 K but then decrease to 0.030 ± 0.010 at 177 K. This unusual trend in temperature dependence of the uptake coefficient is due to formation of an ionic liquid (IL) layer upon the surface reaction of BA with GA, leading to a competition between the rate of desorption of BA and the rates of diffusion and reaction within the IL. …”

Table_1_Comparable Stride Time Fractal Dynamics and Gait Adaptability in Active Young and Older Adults Under Normal and Asymmetric Walking.docx by Scott W. Ducharme (7124309)

“…., fractal dynamics) decreases with age. This decrease is suggested to reflect a reduced capacity for locomotor adaptation in older adults. …”