Effect of 4‑HNE Modification on ZU5-ANK Domain and the Formation of Their Complex with β‑Spectrin: A Molecular Dynamics Simulation Study by Antistio Alviz-Amador (8174016)

“…However, effects at the atomic level of this carbonylation on structure and function of modified protein are not yet fully understood. We present a study based on molecular dynamics simulations of nine 4-HNE modified residues of the ZU5-ANK ankyrin domain with β-spectrin and their binding energy profiles. …”

Effect of 4‑HNE Modification on ZU5-ANK Domain and the Formation of Their Complex with β‑Spectrin: A Molecular Dynamics Simulation Study by Antistio Alviz-Amador (8174016)

“…However, effects at the atomic level of this carbonylation on structure and function of modified protein are not yet fully understood. We present a study based on molecular dynamics simulations of nine 4-HNE modified residues of the ZU5-ANK ankyrin domain with β-spectrin and their binding energy profiles. …”

Downregulation of <i>wnt5b</i> during gastrulation by <i>lbx1b</i> overexpression. by Long Guo (548453)

“…<p>(A) <i>In situ</i> hybridization for non-canonical Wnt/PCP ligands (<i>wnt5b</i> and <i>wnt11</i>) in control and <i>lbx1b</i>-overexpressing embryos at 90% epiboly. …”

miR-10b confers anchorage-independence and increases invasive capacity of melanoma cell lines. by Ila Datar (433874)

Intensification of Antiretroviral Therapy with a CCR5 Antagonist in Patients with Chronic HIV-1 Infection: Effect on T Cells Latently Infected by Carolina Gutiérrez (192894)

B-Raf^V600E melanoma cells acquire cancer phenotypes partly by increasing the expression levels of miR-10b. by Ila Datar (433874)

“…<p>(a) Upper panel: B-Raf^V600E knockdown decreases number of colonies in soft agar in sk-mel-28 cell line. …”

Relative <i>CHRNA5</i> promoter activity in BE(2)-C cells. by Glenn A. Doyle (209929)

“…The deletion (“d” in construct name) or normal (“i” in construct name) allele at rs3841324 is indicated by a red triangle or blue square, respectively. The deletion (“d”) constructs exhibited decreased activity (1.6–2.0-fold) relative to the normal (“i”) constructs. …”

LOH unlinks 189R/R from a stop codon with masking effects on phenotype. by Pétra Vande Zande (17628246)

Long-noncoding RNA HOXA transcript at the distal tip ameliorates the insulin resistance and hepatic gluconeogenesis in mice with gestational diabetes mellitus via the microRNA-423-... by Qianqian Cao (7309022)

“…The relations among HOTTIP, miR-423-5p and WNT7A were validated. HOTTIP and WNT7A levels were decreased while miR-423-5p was elevated in GDM mice. …”

Exendin–4 and metformin decrease the number of Ki67 and P504S-positive cells, and increase GLP-1R expression. by Yoko Tsutsumi (803696)

Anti-influenza A virus activity of rhein through regulating oxidative stress, TLR4, Akt, MAPK, and NF-κB signal pathways - Fig 4 by Qian-Wen Wang (3467420)

Comparing A) ROS and B) GSH levels in COCs versus DOs recovered from PMSG-stimulated NMRI mice cultured in absence or presence of 0.5 µM PA during IVM. Data are presented as means... by Shahrzad Ronasi (20933556)

Impact of LVAD support level on infarct size in a dog model of ischemia reperfusion. by Keita Saku (714525)

“…Compared to control (no LVAD support, n = 6), p-LVAD (n = 5) moderately lowers the infarct ratio (<i>p</i> = 0.011), while t-LVAD (n = 5) strikingly decreases the infarct ratio by more than 80% (<i>p</i><0.01). …”

DataSheet4_Yi-Shen-Hua-Shi granules inhibit diabetic nephropathy by ameliorating podocyte injury induced by macrophage-derived exosomes.ZIP by Mingzhu Liang (11011660)

“…Compared with the exosomes secreted by macrophages after an HG treatment, the exosome from macrophages treated with HG and YSHS granule showed lower inhibitory effects on podocyte activity, accompanied by the decreased upregulating effects of macrophage-derived exosomes on the miR-21a-5p in podocytes. miR-21a-5p mimics could reduce podocyte activity and promote caspase-3 shearing. …”

DataSheet2_Yi-Shen-Hua-Shi granules inhibit diabetic nephropathy by ameliorating podocyte injury induced by macrophage-derived exosomes.ZIP by Mingzhu Liang (11011660)

“…Compared with the exosomes secreted by macrophages after an HG treatment, the exosome from macrophages treated with HG and YSHS granule showed lower inhibitory effects on podocyte activity, accompanied by the decreased upregulating effects of macrophage-derived exosomes on the miR-21a-5p in podocytes. miR-21a-5p mimics could reduce podocyte activity and promote caspase-3 shearing. …”

Image1_Yi-Shen-Hua-Shi granules inhibit diabetic nephropathy by ameliorating podocyte injury induced by macrophage-derived exosomes.TIFF by Mingzhu Liang (11011660)

“…Compared with the exosomes secreted by macrophages after an HG treatment, the exosome from macrophages treated with HG and YSHS granule showed lower inhibitory effects on podocyte activity, accompanied by the decreased upregulating effects of macrophage-derived exosomes on the miR-21a-5p in podocytes. miR-21a-5p mimics could reduce podocyte activity and promote caspase-3 shearing. …”

Table1_Yi-Shen-Hua-Shi granules inhibit diabetic nephropathy by ameliorating podocyte injury induced by macrophage-derived exosomes.DOCX by Mingzhu Liang (11011660)

“…Compared with the exosomes secreted by macrophages after an HG treatment, the exosome from macrophages treated with HG and YSHS granule showed lower inhibitory effects on podocyte activity, accompanied by the decreased upregulating effects of macrophage-derived exosomes on the miR-21a-5p in podocytes. miR-21a-5p mimics could reduce podocyte activity and promote caspase-3 shearing. …”

DataSheet1_Yi-Shen-Hua-Shi granules inhibit diabetic nephropathy by ameliorating podocyte injury induced by macrophage-derived exosomes.ZIP by Mingzhu Liang (11011660)

“…Compared with the exosomes secreted by macrophages after an HG treatment, the exosome from macrophages treated with HG and YSHS granule showed lower inhibitory effects on podocyte activity, accompanied by the decreased upregulating effects of macrophage-derived exosomes on the miR-21a-5p in podocytes. miR-21a-5p mimics could reduce podocyte activity and promote caspase-3 shearing. …”

DataSheet6_Yi-Shen-Hua-Shi granules inhibit diabetic nephropathy by ameliorating podocyte injury induced by macrophage-derived exosomes.ZIP by Mingzhu Liang (11011660)

“…Compared with the exosomes secreted by macrophages after an HG treatment, the exosome from macrophages treated with HG and YSHS granule showed lower inhibitory effects on podocyte activity, accompanied by the decreased upregulating effects of macrophage-derived exosomes on the miR-21a-5p in podocytes. miR-21a-5p mimics could reduce podocyte activity and promote caspase-3 shearing. …”

DataSheet7_Yi-Shen-Hua-Shi granules inhibit diabetic nephropathy by ameliorating podocyte injury induced by macrophage-derived exosomes.ZIP by Mingzhu Liang (11011660)

“…Compared with the exosomes secreted by macrophages after an HG treatment, the exosome from macrophages treated with HG and YSHS granule showed lower inhibitory effects on podocyte activity, accompanied by the decreased upregulating effects of macrophage-derived exosomes on the miR-21a-5p in podocytes. miR-21a-5p mimics could reduce podocyte activity and promote caspase-3 shearing. …”