Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

KS1 and KS2 combined RNA-seq experiment differentially expressed genes: <i>Kmt2d</i>^<i>-/-</i> vs <i>Kmt2d</i>^<i>+/+</i>, Day 7. by Christine W. Gao (18794576)

Developmental toxicity induced by 2 μg/ml propofol. by Yali Ge (417371)

Assessment of similarities between selected terms and their nearest neighbors present in 4 embeddings. by Halima Alachram (11570633)

Superposition of conserved PARG1 C1-RhoGAP domains bound to RhoA protein. by Zen Kouchi (14898435)

Impact of age on sharing of top 5000 TCRβ clones. by Sarah A. Johnson (11355817)

Serum cholesterol concentrations in hyperthyroid cats and euthyroid controls. by Molly A. Bechtold (18794251)

Proteome and Metabolome Profiling of Anticoagulant Disorders Induced by Familial Protein S Deficiency by Caiping Zhang (6745976)

PPM1A facilitates both nuclear distribution and transcription potency of YAP/TAZ. by Ruyuan Zhou (10197187)

“…<b>(B–D)</b> Transcription potency of YAP (5 ng), which was suppressed by coexpression of MST1 (50 ng) (B), LATS1 (500 ng) (C), or MAP4K1 (50 ng) (D), was markedly recovered by cotransfection of wild-type PPM1A but not the enzyme-dead PPM1A (D239N). …”

Sub-counties by key attributes. by Eric Nturibi (10163914)

“…We will conduct a 12-month stepped wedge cluster randomized trial involving 15-24-year-old HIV patients with smartphone access. …”

Life cycle of a digital intervention. by Eric Nturibi (10163914)

“…We will conduct a 12-month stepped wedge cluster randomized trial involving 15-24-year-old HIV patients with smartphone access. …”

COM-B theoretical framework for behaviour change. by Eric Nturibi (10163914)

“…We will conduct a 12-month stepped wedge cluster randomized trial involving 15-24-year-old HIV patients with smartphone access. …”

Randomization of clusters into sequences. by Eric Nturibi (10163914)

“…We will conduct a 12-month stepped wedge cluster randomized trial involving 15-24-year-old HIV patients with smartphone access. …”

PICOT framework. by Eric Nturibi (10163914)

“…We will conduct a 12-month stepped wedge cluster randomized trial involving 15-24-year-old HIV patients with smartphone access. …”