Image_1_Extracellular Vesicles Carry lncRNA SNHG16 to Promote Metastasis of Breast Cancer Cells via the miR-892b/PPAPDC1A Axis.TIFF by Wenfei Xia (5055482)

Anti-inflammatory Meroterpenoids from <i>Baeckea frutescens</i> by Ji-Qin Hou (3642946)

“…Compound <b>8</b> exhibited anti-inflammatory activity with an IC₅₀ value of 0.36 μM, which might be related to the regulation of the NF-κB signaling pathway via the suppression of p65 nuclear translocation and the consequent decrease of IL-6 and TNF-α.…”

Anti-inflammatory Meroterpenoids from <i>Baeckea frutescens</i> by Ji-Qin Hou (3642946)

“…Compound <b>8</b> exhibited anti-inflammatory activity with an IC₅₀ value of 0.36 μM, which might be related to the regulation of the NF-κB signaling pathway via the suppression of p65 nuclear translocation and the consequent decrease of IL-6 and TNF-α.…”

Anti-inflammatory Meroterpenoids from <i>Baeckea frutescens</i> by Ji-Qin Hou (3642946)

“…Compound <b>8</b> exhibited anti-inflammatory activity with an IC₅₀ value of 0.36 μM, which might be related to the regulation of the NF-κB signaling pathway via the suppression of p65 nuclear translocation and the consequent decrease of IL-6 and TNF-α.…”

High blood glucose levels in rats after exposure to STZ. by Shatw Khalid Ali (13020885)

Potent 5‑Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1–UBE2M Interaction by Wenjuan Zhou (115285)

“…After finding a novel inhibitor <b>DC-1</b> with IC₅₀ = 1.2 μM, we performed a series of chemical optimizations, which finally led to the discovery of a potent thiazole containing 5-cyano-6-phenylpyrimidin-based inhibitor <b>DC-2</b> (IC₅₀ = 15 nM). …”

Enantiomeric Deoxycholic Acid:  Total Synthesis, Characterization, and Preliminary Toxicity toward Colon Cancer Cell Lines by Bryson W. Katona (2465581)

“…To further explore DCA induced changes in cell signaling, we completed a total synthesis of enantiomeric deoxycholic acid (<i>ent</i>-DCA) from achiral 2-methyl-1,3-cyclopentanedione. Using a modified method of the synthesis of <i>ent</i>-testosterone that proceeds through the (<i>R</i>)-(−)-Hajos−Parrish ketone, we have completed the successful synthesis of <i>ent</i>-DCA in 25 steps with a yield of 0.3% with all stereochemical assignments of the product confirmed by X-ray crystallography. …”

Enantiomeric Deoxycholic Acid:  Total Synthesis, Characterization, and Preliminary Toxicity toward Colon Cancer Cell Lines by Bryson W. Katona (2465581)

“…To further explore DCA induced changes in cell signaling, we completed a total synthesis of enantiomeric deoxycholic acid (<i>ent</i>-DCA) from achiral 2-methyl-1,3-cyclopentanedione. Using a modified method of the synthesis of <i>ent</i>-testosterone that proceeds through the (<i>R</i>)-(−)-Hajos−Parrish ketone, we have completed the successful synthesis of <i>ent</i>-DCA in 25 steps with a yield of 0.3% with all stereochemical assignments of the product confirmed by X-ray crystallography. …”

Enantiomeric Deoxycholic Acid:  Total Synthesis, Characterization, and Preliminary Toxicity toward Colon Cancer Cell Lines by Bryson W. Katona (2465581)

“…To further explore DCA induced changes in cell signaling, we completed a total synthesis of enantiomeric deoxycholic acid (<i>ent</i>-DCA) from achiral 2-methyl-1,3-cyclopentanedione. Using a modified method of the synthesis of <i>ent</i>-testosterone that proceeds through the (<i>R</i>)-(−)-Hajos−Parrish ketone, we have completed the successful synthesis of <i>ent</i>-DCA in 25 steps with a yield of 0.3% with all stereochemical assignments of the product confirmed by X-ray crystallography. …”

Enantiomeric Deoxycholic Acid:  Total Synthesis, Characterization, and Preliminary Toxicity toward Colon Cancer Cell Lines by Bryson W. Katona (2465581)

“…To further explore DCA induced changes in cell signaling, we completed a total synthesis of enantiomeric deoxycholic acid (<i>ent</i>-DCA) from achiral 2-methyl-1,3-cyclopentanedione. Using a modified method of the synthesis of <i>ent</i>-testosterone that proceeds through the (<i>R</i>)-(−)-Hajos−Parrish ketone, we have completed the successful synthesis of <i>ent</i>-DCA in 25 steps with a yield of 0.3% with all stereochemical assignments of the product confirmed by X-ray crystallography. …”

The effects of metformin, donepezil, insulin glargine, and glibenclamide on brain biomarkers: Amyloid β 42, nitric oxide, acetylcholinesterase, malondialdehyde, β secretase, and pM... by Shatw Khalid Ali (13020885)

A trial of seven footfalls in which the subject (emu) underwent a gradual deceleration. by P. J. Bishop (4219759)

Activity of miR-124 and miR-23a in NSC-derived neurons and astrocytes. by Annalisa Lattanzi (427545)

“…(B–E) A significant decrease of GFP expression is observed in bdLV.miRT124-transduced neurons (βtubIII, MAP2) (<b>B, C</b>) and in bdLV.miRT23a-transduced astrocytes (GFAP) and immature glial cells (nestin) (<b>D, E</b>). …”

Linear stability of the flow of a second order fluid past a wedge by Martina Cracco (19655263)

Individual based stochastic simulation as two type Moran process. by Benjamin Werner (194068)

“…At time there are resistant cells and wild type cells. During the next time step three cases are possible: (i) the number of resistant cells increases by one with probability , (ii) stays the same with probability (iii) or decreases by one with probability , (see equation (2a) and (2b)).…”

Elution profile of PC-Sepharose and SDSPAGE analysis. by Rafael I. Monsalve (2948826)

“…The SDSPAGE in the inset shows the proteins separated in these steps: Lane 1 corresponds to the initial extract, lane 2 corresponds to the FT, and lane 3 to the Vesp v 1 peak. …”

The effect of glibenclamide on channel activity at +20, 0 and -20 mV. by Sajjad Salari (736104)

“…Histogram bars show current amplitudes and P_o of reconstituted channels in absence or presence of glibenclamide. The addition of 50 μM glibenclamide resulted in a decreased current jump amplitude and a reduction in P_o. 100 μM glibenclamide caused a total channel inhibition at +20 and 0 mV (n = 5), but was ineffective at -20 mV. …”

Solvent Dependent Fluorescent Properties of a 1,2,3-Triazole Linked 8-Hydroxyquinoline Chemosensor: Tunable Detection from Zinc(II) to Iron(III) in the CH₃CN/H<sub>2</su... by Erhong Hao (1365990)

“…A triazole-containing 8-hydroxyquinoline (8-HQ) ether <b>2</b> was efficiently synthesized in two steps from the “click” strategy. …”

S1 Fig - by Caleb Larnerd (20664157)

ICA decomposition quality is sensitive to recording spatial and temporal resolution. by Sydney C. Weiser (15383531)