Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers by Viera Dobrotkova (6832433)

“…We found that the cell lines that were HMGA2-positive and/or HOXC9-negative have a reduced sensitivity to retinoids. Furthermore, the experiments revealed that the retinoid-sensitive cell lines showed a uniform pattern of change after treatment with both natural and sensitive retinoids: increased DDX39A and decreased PBX1 protein levels. …”

Supplementary Material for: Development of a root caries prediction model in a population of dental attenders by Fee P.A. (13545517)

Temperature-dependence of A) the ratio of rate constants k1/k2. The presence of the DII loop made the first rate constant ratio less affected by temperature changes, as seen for <i... by Roberto F. Delgadillo (843498)

RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity by Brandon L. Probst (727964)

“…Here, we characterized the in vitro antioxidant, anti-inflammatory, and anticancer activities of RTA 408, a novel AIM that is currently being evaluated in patients with advanced malignancies. …”

FLIM FRET efficiency of: (A) αA-crystallin (B) WT αB-crystallin, their deamidated and domain mutants. by Ekta Tiwary (836674)

Data file. by Maryam Khalaji (21743611)

“…The results showed that mental fatigue significantly decreased QE duration (Mean difference = −138.75 ms, p = .0009) and fixation duration (Mean difference = 67.50 ms, p = .001), indicating a detrimental effect on sustained attention. …”

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…In this work, we reported the structure-based design of triazolo­[1,5-<i>a</i>]­pyrimidines as new ABCB1 modulators, of which <b>WS-691</b> significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC₅₀ = 22.02 nM). …”

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…In this work, we reported the structure-based design of triazolo­[1,5-<i>a</i>]­pyrimidines as new ABCB1 modulators, of which <b>WS-691</b> significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC₅₀ = 22.02 nM). …”

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…In this work, we reported the structure-based design of triazolo­[1,5-<i>a</i>]­pyrimidines as new ABCB1 modulators, of which <b>WS-691</b> significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC₅₀ = 22.02 nM). …”

N⁶-methyladenosine-dependent primary microRNA-126 processing activated PI3K-AKT-mTOR pathway drove the development of pulmonary fibrosis induced by nanoscale carbon blac... by Bin Han (45760)

“…We found that both of m⁶A modifications of pri-miRNA-126 and its binding with DGCR8 were decreased after CB treatment, which resulted in the reduction of mature miRNA-126 accompanied by accumulation of unprocessed pri-miRNA-126. …”

On a steepening environmental gradient, a sharp and stable range margin forms near the expansion threshold. by Jitka Polechová (5400749)

“…(<b>b</b>) As the environmental gradient steepens, the frequency of limited adaptation within the metapopulation increases (black and grey), and hence neutral variation decreases (blue). The black line gives the proportion of demes with limited adaptation after 50,000 generations, when the range margin appears stable; grey gives the proportion after 40,000 generations (depicted is an average over a sliding window of 15 demes). …”

DataSheet_1_A20 Establishes Negative Feedback With TRAF6/NF-κB and Attenuates Early Brain Injury After Experimental Subarachnoid Hemorrhage.zip by Hong-Ji Deng (11182902)

“…<p>Nuclear factor (NF)-κB–ty -50mediated neuroinflammation plays a crucial role in early brain injury (EBI) after subarachnoid hemorrhage (SAH). …”

Course of T_body of a female pup before, during and after a thunderstorm. by Nicola Erdsack (443390)

“…</b>: The thunderstorm stopped but it still rained on. <b>5:50 p.m.</b>: T_air = 19.7°C. T_body had decreased by 0.7°C to 36.9°C. …”

Importance of the features. by Zhi Jiang (269212)

Variable selection in the RF algorithm. by Zhi Jiang (269212)

DN Rab5 (S34N) retards endocytosis of KCa2.3. by Yajuan Gao (309862)

“…</b> Expression of S34N Rab5 resulted in a significant decrease of KCa2.3 endocytosis, relative to WT Rab5 (<i>n</i> = 3; *P<0.05). …”

Reversible Interconversion Between a Monomeric Iridium Hydroxo and a Dinuclear Iridium μ‑Oxo Complex by Richard J. Burford (1841908)

“…Eyring analysis is consistent with the bimolecular nature of the reaction, with Δ<i>H</i>^⧧ = 13.1(5) kcal mol^–1 and Δ<i>S</i>^⧧ = −13(2) cal K^–1. Finally, <i>k</i>_obs is observed to increase when electron-withdrawing groups are incorporated in the <i>para</i> position of the phenol substrate and decrease when electron-donating groups are employed. …”

Maternal kidney changes due to STZ administration and pregnancy. by Narumi Takahashi (5343218)

Dynamic binding of patient serum antibody isotypes over short to medium term for moderate and mild COVID-19 disease. by Marie Le Berre (6299012)

Healthy control group HR and CBF changes. by Liuchuang Wei (19273099)

“…Computational results revealed that hypovolemia reduces cerebral blood flow by approximately 100 mL/min due to a 30% decrease in blood volume, while vascular dysfunction—marked by a 50–100% increase in arterial stiffness—further diminishes cardiac output and cerebral perfusion. …”