KatN is crucial for the survival of EHEC in macrophages. by Baoshan Wan (3833551)

“…<p>(A) The intracellular survival of the WT, Δ<i>katN</i> and Δ<i>katN-</i>c in RAW264.7 macrophages. …”

UTX-1 is required for VPA action in <i>C. elegans</i> embryos and in human cells. by Rakel Brendsdal Forthun (121022)

“…Numbers shown are arbitrary units compared to negative control siRNA. The blot shows a 60% decrease in UTX by siRNA treatment, confirming the efficacy of transfection. …”

Simultaneous Multi-Species Tracking in Live Cells with Quantum Dot Conjugates by Mathias P. Clausen (492769)

“…We show that a large number of the trajectories are longer than 50 steps, which we by simulations show to be sufficient for robust single trajectory analysis. …”

DataSheet1_Evaluation of the immune response of peripheral blood mononuclear cells cultured on Ti6Al4V-ELI polished or etched surfaces.pdf by Hugo Abreu (19815654)

“…</p>Discussion<p>The dysregulation of the cytokine profile upon contact with untreated Ti6Al4V-ELI discs, namely upregulation of IL-2 could be responsible for the decrease in Th17 frequency, and thus might contribute to implant-associated bacterial infection. …”

Data_Sheet_1_Genome-Wide Expression Analysis of Glyoxalase I Genes Under Hyperosmotic Stress and Existence of a Stress-Responsive Mitochondrial Glyoxalase I Activity in Durum Wheat... by Mario Soccio (12961406)

“…Expression profile by qRT-PCR analysis revealed that most of the putative active TdGLYI genes were up-regulated by salt and osmotic stress in roots and shoots from 4-day-old seedlings, although a different behavior was observed between the two types of stress and tissue. Accordingly, in the same tissues, hyperosmotic stress induced an increase (up to about 40%) of both GLYI activity and MG content as well as a decrease of GSH (up to about –60%) and an increase of GSSG content (up to about 7-fold) with a consequent strong decrease of the GSH/GSSG ratio (up to about –95%). …”

Table_1_Genome-Wide Expression Analysis of Glyoxalase I Genes Under Hyperosmotic Stress and Existence of a Stress-Responsive Mitochondrial Glyoxalase I Activity in Durum Wheat (Tri... by Mario Soccio (12961406)

“…Expression profile by qRT-PCR analysis revealed that most of the putative active TdGLYI genes were up-regulated by salt and osmotic stress in roots and shoots from 4-day-old seedlings, although a different behavior was observed between the two types of stress and tissue. Accordingly, in the same tissues, hyperosmotic stress induced an increase (up to about 40%) of both GLYI activity and MG content as well as a decrease of GSH (up to about –60%) and an increase of GSSG content (up to about 7-fold) with a consequent strong decrease of the GSH/GSSG ratio (up to about –95%). …”

Data_Sheet_3_Genome-Wide Expression Analysis of Glyoxalase I Genes Under Hyperosmotic Stress and Existence of a Stress-Responsive Mitochondrial Glyoxalase I Activity in Durum Wheat... by Mario Soccio (12961406)

“…Expression profile by qRT-PCR analysis revealed that most of the putative active TdGLYI genes were up-regulated by salt and osmotic stress in roots and shoots from 4-day-old seedlings, although a different behavior was observed between the two types of stress and tissue. Accordingly, in the same tissues, hyperosmotic stress induced an increase (up to about 40%) of both GLYI activity and MG content as well as a decrease of GSH (up to about –60%) and an increase of GSSG content (up to about 7-fold) with a consequent strong decrease of the GSH/GSSG ratio (up to about –95%). …”

Gene-gene interaction network underlying LRO accumulation of Nile red and autofluorescence. by Alexander A. Soukas (476353)

“…(F) RNAi to acyl-coenzyme A synthetase <i>acs-6</i> increases blue autofluorescence in a manner genetically dependent upon TOR complex 2 mutant <i>rict-1</i>. (C–F, N as in table S3 and S4; significance by unequal variance, two-tailed Student's t-test with Bonferroni step-down correction.)…”

Image_1_Genome-Wide Expression Analysis of Glyoxalase I Genes Under Hyperosmotic Stress and Existence of a Stress-Responsive Mitochondrial Glyoxalase I Activity in Durum Wheat (Tri... by Mario Soccio (12961406)

“…Expression profile by qRT-PCR analysis revealed that most of the putative active TdGLYI genes were up-regulated by salt and osmotic stress in roots and shoots from 4-day-old seedlings, although a different behavior was observed between the two types of stress and tissue. Accordingly, in the same tissues, hyperosmotic stress induced an increase (up to about 40%) of both GLYI activity and MG content as well as a decrease of GSH (up to about –60%) and an increase of GSSG content (up to about 7-fold) with a consequent strong decrease of the GSH/GSSG ratio (up to about –95%). …”

Proxy-based paleoclimate series for the last 5000 years. by David Kaniewski (218243)

“…Positive scores correspond to higher humidity whereas negative scores indicate dry periods <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071004#pone.0071004-Kaniewski1" target="_blank">[11]</a>; (<b>c</b>) Time-series (5000 BP to present by step of 100 years) of annual precipitation (anomalies from the present in mm/yr) averaged on Southeastern Mediterranean region (longitude 20°E−50°E, latitude 30°N-45°N); the data are reconstructed from pollen data extracted from the European Pollen Database; (<b>d</b>) fluctuations in Nile floods, indicated by lake level variations of Lake Qarun (Fayum depression, Egypt) inferred from paleoshorelines and lake sediments <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071004#pone.0071004-Hassan2" target="_blank">[73]</a>; (<b>e</b>) reconstruction of annual precipitation based on botanical-climatological transfer functions applied to pollen data from Ain Gedi sediments (Dead Sea shore) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071004#pone.0071004-Litt1" target="_blank">[15]</a>; (<b>f</b>) Abundance of Cyperaceae pollen, a marker of fresh water input, in a sediment core from Burullus Lagoon in the north-central Nile Delta <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071004#pone.0071004-Bernhardt1" target="_blank">[14]</a>. …”

Table_2_Development and validation of risk-adjusted quality indicators for the long-term outcome of acute sepsis care in German hospitals based on health claims data.DOCX by Lisa Wedekind (4994441)

“…Because of a small case-volume per hospital, applying reliability adjustment to the RSMR led to a great decrease in variability across hospitals [from median (1st quartile, 3rd quartile) 54.2% (44.3%, 65.5%) to 53.2% (50.7%, 55.9%) for 90-day mortality; from 39.2% (27.8%, 51.1%) to 39.9% (39.5%, 40.4%) for the 1-year composite endpoint]. …”

Table_1_Development and validation of risk-adjusted quality indicators for the long-term outcome of acute sepsis care in German hospitals based on health claims data.DOCX by Lisa Wedekind (4994441)

“…Because of a small case-volume per hospital, applying reliability adjustment to the RSMR led to a great decrease in variability across hospitals [from median (1st quartile, 3rd quartile) 54.2% (44.3%, 65.5%) to 53.2% (50.7%, 55.9%) for 90-day mortality; from 39.2% (27.8%, 51.1%) to 39.9% (39.5%, 40.4%) for the 1-year composite endpoint]. …”

Image_1_Development and validation of risk-adjusted quality indicators for the long-term outcome of acute sepsis care in German hospitals based on health claims data.TIF by Lisa Wedekind (4994441)

“…Because of a small case-volume per hospital, applying reliability adjustment to the RSMR led to a great decrease in variability across hospitals [from median (1st quartile, 3rd quartile) 54.2% (44.3%, 65.5%) to 53.2% (50.7%, 55.9%) for 90-day mortality; from 39.2% (27.8%, 51.1%) to 39.9% (39.5%, 40.4%) for the 1-year composite endpoint]. …”

Localisation and quantification of NL2 immunoreactivity within the hippocampus of WT and dystrophin-deficient mice, reacted and imaged under identical conditions. by Elżbieta Krasowska (635317)

“…Scale bars (A1, B1, C1) 50 µm; (A2, B2, C2) 10 µm; (A3, B3, C3) 5 µm.…”

Secondary screening and ‘hit’ validation. by Ilona Tkachyova (343715)

“…Distinct decrease in <i>NDST1</i> expression was observed for 2x IC₅₀ SAHA treatment. …”

<i>Listeria monocytogenes</i> InlP interacts with afadin and facilitates basement membrane crossing by Cristina Faralla (5318225)

“…A crystal structure of InlP reveals several unique features, including an extended leucine-rich repeat (LRR) domain with a distinctive Ca²⁺-binding site. Despite afadin’s involvement in the formation of cell-cell junctions, MDCK epithelial cells expressing InlP displayed a decrease in the magnitude of the traction stresses they could exert on deformable substrates, similar to the decrease in traction exhibited by <i>AF-6</i> knock-out MDCK cells. …”

Supplementary Figures from Impact of the 2015–2016 El Nino on the terrestrial carbon cycle constrained by bottom-up and top-down approaches by Ana Bastos (4808796)

“…First, we provide a synthesis of the spatio-temporal evolution of anomalies in net land-atmosphere CO₂ fluxes estimated by two <i>in situ</i> measurements based on atmospheric inversions and 16 land-surface models (LSMs) from TRENDYv6. …”

Supplementary Datasets from Impact of the 2015–2016 El Nino on the terrestrial carbon cycle constrained by bottom-up and top-down approaches by Ana Bastos (4808796)

“…First, we provide a synthesis of the spatio-temporal evolution of anomalies in net land-atmosphere CO₂ fluxes estimated by two <i>in situ</i> measurements based on atmospheric inversions and 16 land-surface models (LSMs) from TRENDYv6. …”

Studies of changes in concentration under different perturbation scenarios. by Xu Gu (276054)

Role of Mixed Boundaries on Flow in Open Capillary Channels with Curved Air–Water Interfaces by Wenjuan Zheng (2049133)

“…Consequently, flow regimes may differ markedly from conventional flows, reflecting strong interfacial influences on small bodies of flowing liquids. In this work, we visualized liquid transport patterns in open capillary channels with a range of opening sizes from 0.6 to 5.0 mm using laser scanning confocal microscopy combined with fluorescent latex particles (1.0 μm) as tracers at a mean velocity of ∼0.50 mm s^–1. …”