50 year old female with Libman-Sacks endocarditis complicated with an acute transient ischemic attack, past stroke, and seizure disorder. by Carlos A. Roldan (10151007)

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

nsP4-C483Y or Q192L mutations decrease sensitivity to 4′-FlU. by Peiqi Yin (6533747)

LPS administration demonstrated a significant decrease in the protein expression of both claudin-1 and occludin in BF fed mice as compared to control mice. by Valentina Di Caro (510473)

Leptin deficit hypoxia exposed-MSCs failed to limit cardiac fibroblast activation, through TGF-β/Smad2 and MRTF-A. by Panpan Chen (307628)

Effect of MF (2 MT, 50 Hz) on VEGFR expression and activation. by Simona Delle Monache (402973)

“…<p>Protein of equal quantity was separated by 8% SDS-page and electroblotted on to a PVDF membrane. Representative blots show effects exerted by MF (2 mT, 50 Hz) on VEGFR2 total expression and phosphorylation after 1 h, 6 h and 12 h of exposure A). …”

ChemRich enrichment of the top 50 most changed metabolites for SCD. by Juliette Cooke (11402543)

A small group of plains zebra taken at a real-world equivalent of 16.4 m as they may appear to a human (a,c,e) and lion (b,d,f) under photopic (bright; daylight), mesopic (dim; dus... by Amanda D. Melin (270203)

Image5_PKA inhibition is a central step in D,L-methadone-induced ER Ca2+ release and subsequent apoptosis in acute lymphoblastic leukemia.JPEG by Hamza Kamran (18433152)

“…This is consistent with the decrease in PKA-dependent (i) inhibitory PLCβ3 Ser1105 phosphorylation that leads to PLCβ3 activation and ER Ca²⁺ release, and (ii) BAD Ser118 phosphorylation, which together ultimately result in caspase activation and apoptosis. …”

Image4_PKA inhibition is a central step in D,L-methadone-induced ER Ca2+ release and subsequent apoptosis in acute lymphoblastic leukemia.JPEG by Hamza Kamran (18433152)

“…This is consistent with the decrease in PKA-dependent (i) inhibitory PLCβ3 Ser1105 phosphorylation that leads to PLCβ3 activation and ER Ca²⁺ release, and (ii) BAD Ser118 phosphorylation, which together ultimately result in caspase activation and apoptosis. …”

Image7_PKA inhibition is a central step in D,L-methadone-induced ER Ca2+ release and subsequent apoptosis in acute lymphoblastic leukemia.JPEG by Hamza Kamran (18433152)

“…This is consistent with the decrease in PKA-dependent (i) inhibitory PLCβ3 Ser1105 phosphorylation that leads to PLCβ3 activation and ER Ca²⁺ release, and (ii) BAD Ser118 phosphorylation, which together ultimately result in caspase activation and apoptosis. …”

Image6_PKA inhibition is a central step in D,L-methadone-induced ER Ca2+ release and subsequent apoptosis in acute lymphoblastic leukemia.JPEG by Hamza Kamran (18433152)

“…This is consistent with the decrease in PKA-dependent (i) inhibitory PLCβ3 Ser1105 phosphorylation that leads to PLCβ3 activation and ER Ca²⁺ release, and (ii) BAD Ser118 phosphorylation, which together ultimately result in caspase activation and apoptosis. …”

Image1_PKA inhibition is a central step in D,L-methadone-induced ER Ca2+ release and subsequent apoptosis in acute lymphoblastic leukemia.JPEG by Hamza Kamran (18433152)

“…This is consistent with the decrease in PKA-dependent (i) inhibitory PLCβ3 Ser1105 phosphorylation that leads to PLCβ3 activation and ER Ca²⁺ release, and (ii) BAD Ser118 phosphorylation, which together ultimately result in caspase activation and apoptosis. …”

Image3_PKA inhibition is a central step in D,L-methadone-induced ER Ca2+ release and subsequent apoptosis in acute lymphoblastic leukemia.JPEG by Hamza Kamran (18433152)

“…This is consistent with the decrease in PKA-dependent (i) inhibitory PLCβ3 Ser1105 phosphorylation that leads to PLCβ3 activation and ER Ca²⁺ release, and (ii) BAD Ser118 phosphorylation, which together ultimately result in caspase activation and apoptosis. …”

50% reduction of kinesin-1 or dynein is sufficient to perturb neuronal growth. by Gary J. Iacobucci (192833)

“…<p>(<b>A</b>) Representative neuronal cultures expressing APP-YFP and APP-YFP with 50% genetic reduction of either kinesin-1 or dynein are shown at day 1 and day 2. …”

Table_1_Decrease in Admissions and Change in the Diagnostic Landscape in a Newborn Care Unit in Northern Ghana During the COVID-19 Pandemic.DOC by Alhassan Abdul-Mumin (5986151)

“…</p><p>Conclusion: We observed a marked decrease in admissions and change in the diagnosis landscape and related mortality during the pandemic. …”

Dependence of seizure transition times on (<i>dν</i>_<i>se</i>/<i>dt</i>)^−1/2 with the default parameters as in Table 1 and Δ ranges from 2 s to 50 s. by F. Deeba (8661837)

Data_Sheet_1_Circulating vitamin levels mediate the causal relationship between gut microbiota and cholecystitis: a two-step bidirectional Mendelian randomization study.docx by Changhong Miao (422474)

“…Subsequently, we conducted a two-step analysis to investigate the causal effects between gut microbiota and cholecystitis. …”

Neural networks classify states which differ in neuronal activity levels using ensembles of neurons that increase/decrease their activity in each state. by Nicholas A. Frost (10739821)

“…As a result, there is an increase (neurons 51:100) or decrease (neurons 1:50) in activity levels in State B compared to State A. …”