Discovery of Novel Substituted <i>N</i>‑(4-Amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide Analogues as Potent Human Adenovirus Inhibitors by Jimin Xu (2208961)

“…An effective therapy for human adenovirus (HAdV) infections in immunocompromised patients and healthy individuals with community-acquired pneumonia remains an unmet medical need. We herein reported a series of novel substituted <i>N</i>-(4-amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide analogues as potent HAdV inhibitors. …”

Table_1_Why Does Child Mortality Decrease With Age? Modeling the Age-Associated Decrease in Mortality Rate Using WHO Metadata From 25 Countries.XLSX by Josef Dolejs (5534258)

Frequency of the number of peaks (<i>N</i>_pics) (black, left vertical axis) and average amplitude of pics (<i>A</i>_pics) (red, right vertical axis) observed i... by Sławomir Grzegorczyn (12035398)

Fig 13 - by Jianbo Jia (717814)

“…Finally, by making corresponding test blocks, it was found that the peak value of forward resistance when the 10.5°test block crossed the steps of 1mm, 2mm and 3mm height decreased by 19.8%, 25.0% and 13.9% respectively, and the mean value decreased by 30.8%, 27.2% and 24.1% respectively, which was close to the simulation results, and verified the accuracy of the finite element analysis results.…”

Monofunctional Hyperbranched Ethylene Oligomers by Thomas Wiedemann (1850746)

“…The neutral κ²<i>N</i>,<i>O</i>-salicylaldiminato Ni­(II) complexes [κ²<i>N</i>,<i>O</i>-{(2,6-(3′,5′-R₂C₆H₃)₂C₆H₃-NC­(H)-(3,5-I₂-2-O-C₆H₂)}]­NiCH₃(pyridine)] (<b>1a-pyr</b>, R = Me; <b>1b-pyr</b>, R = Et; <b>1c-pyr</b>, R = <i>i</i>Pr) convert ethylene to hyperbranched low-molecular-weight oligomers (<i>M</i>_n ca. 1000 g mol^–1) with high productivities. …”

DAS and Y27632 down-regulated the mRNA and protein expression of CK8-RhoA/ROCK1 pathway and up-regulated TJs expression in intestines of infected mice. by Wen Wen Zheng (17721404)

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qPCR analysis of CK8 knockdown affecting Clauding-1 mRNA expression. by Wen Wen Zheng (17721404)

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PAS staining of intestinal sections from <i>T. spiralis</i>-infected mice pretreated with DAS and Y27632. by Wen Wen Zheng (17721404)

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qPCR and Western blotting of CK8 knockdown blocking the rTsSPc-activated pathway and -reduced TJs expression. by Wen Wen Zheng (17721404)

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IFA, GST pull-down and Co-IP assay of specific binding between rTsSPc and CK8. by Wen Wen Zheng (17721404)

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Intraperitoneal injection protocol for inhibitors (A), inhibitors DAS and Y27632 reduced intestinal permeability (B) and intestinal adult worm burden (C) of infected mice. by Wen Wen Zheng (17721404)

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HE staining showed that DAS and Y27632 alleviated intestinal inflammation in <i>T. spiralis</i>-infected mice. by Wen Wen Zheng (17721404)

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The ROCK1 pathway inhibitor Y27632 prevented rTsSPc from activating the ROCK1 pathway and reducing TJs expression. by Wen Wen Zheng (17721404)

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qPCR (A-D) and ELISA (E-H) detection of inflammatory cytokines in intestine of <i>T. spiralis</i>-infected mice. by Wen Wen Zheng (17721404)

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Intracellular TFV-DP levels detected in PBMC with a single 2-hour TAF pulse and washout. by Christian Callebaut (2276590)

False-positive percentage by days postpartum (A) and parity (B) utilizing the Rapid Visual Pregnancy Test. by Adalaide C. Kline (19226172)

False positive percentage by days postpartum (A) and parity (B) utilizing the OnFarm Pregnancy Test. by Adalaide C. Kline (19226172)

Mechanical data for the two drill bits in the MIPS system (MIPS GS, MIPS WD) and the single drill bits in the MONO system at different feed rates (mm/s). The data are shown as the... by Marsel Ganeyev (21453399)

The dynamics of sickle RBCs interacting with a macrophage under a blood flow with step-wise changes. by Guansheng Li (10170467)

Self-Healable, Injectable Hydrogel with Enhanced Clotrimazole Solubilization as a Potential Therapeutic Platform for Gynecology by Monika Gosecka (1607017)

“…Injectable, self-healing hydrogels with enhanced solubilization of hydrophobic drugs are urgently needed for antimicrobial intravaginal therapies. Here, we report the first hydrogel systems constructed of dynamic boronic esters cross-linking unimolecular micelles, which are a reservoir of antifungal hydrophobic drug molecules. …”