Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity by Valentina Noemi Madia (1585285)

“…Most of the designed derivatives were active at micromolar or submicromolar concentration, and the most promising compounds are fluorinated and/or amino acids derivatives <b>13a</b>, <b>14d</b>, and <b>15</b> that showed IC₅₀ 0.16–0.82 μM. …”

Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity by Valentina Noemi Madia (1585285)

“…Most of the designed derivatives were active at micromolar or submicromolar concentration, and the most promising compounds are fluorinated and/or amino acids derivatives <b>13a</b>, <b>14d</b>, and <b>15</b> that showed IC₅₀ 0.16–0.82 μM. …”

Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity by Valentina Noemi Madia (1585285)

“…Most of the designed derivatives were active at micromolar or submicromolar concentration, and the most promising compounds are fluorinated and/or amino acids derivatives <b>13a</b>, <b>14d</b>, and <b>15</b> that showed IC₅₀ 0.16–0.82 μM. …”

A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization-5 by Chandrashekhar D Kamat (60176)

“…<p><b>Copyright information:</b></p><p>Taken from "A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization"</p><p>BMC Cardiovascular Disorders 2007;7():4-4.…”

Activation of axonal GABA_A receptors decreases AP-induced Ca²⁺ transients. by Yang Xia (104600)

“…<p>A, Left, projection of 2-photon fluorescence images of a recorded pyramidal neuron filled with Alexa Fluor 594 (50 µM) and OGB-1 (200 µM). …”

Decreased MRPS34 levels cause a reduction in mitochondrial protein synthesis and steady state levels of mitochondrial proteins. by Tara R. Richman (713532)

Loss of primary cilia and decreased nephron number in mice with Tamoxifen-induced <i>Kif3a</i> deficiency. by Lijun Chi (196000)

“…(H) Quantitation of the number of cells with a primary cilium. Tamoxifen administration to <i>Kif3a™</i> embryos decreases cilia number by approximately 50% in both ureteric and metanephric mesenchyme cells (***, P<0.001). …”

Chromosomal Translocations in the Parasite <i>Leishmania</i> by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism by Marie-Claude N. Laffitte (669627)

“…Attempts to generate <i>RAD50</i> null mutants in a wild-type background failed and we provide evidence that this gene is essential. …”

Effect of Ca²⁺ on foam cell formation. by Bruno Musetti (9527085)

A-p50 affects tumor cell survival through inhibition of NF-κB-mediated transcriptional activation by Jing Mi (18654)

“…</p><p>© 2006 The Author(s)</p> () MTT assay of cell viability. Ad-A-p50-infected A549 cells show a significant decrease in cell viability (Ad-A-p50) compared to Ad-siNT-infected cells, = 3–5 per group, = 0.0001. () Hoechst 33342 staining of apoptotic nuclei. …”

<i>Nf1</i> OPG mice exhibit decreased hole poking in response to a novel holeboard apparatus. by David F. Wozniak (78177)

“…(C) <i>Nf1</i> OPG mice also showed a trend toward decreased general ambulatory activity although this difference was also not significant (p = 0.053). …”

Decreased aqueous humor outflow rate in sGCα₁^−/− mice. A by Emmanuel S. Buys (392112)

Targeted point mutation (F639A) in the GluN1 subunit decreases ethanol sensitivity of NMDA receptors. by Carolina R. den Hartog (484817)

A homozygous missense variant in <i>VWA2</i>, encoding an interactor of the Fraser-complex, in a patient with vesicoureteral reflux by Amelie T. van der Ven (4782093)

“…We identified a homozygous missense mutation (c.1336C>T, p.Arg446Cys) in the gene <i>Von Willebrand factor A domain containing 2</i> (<i>VWA2</i>). …”

Morphology Control of Lanthanide Doped NaGdF₄ Nanocrystals via One-Step Thermolysis by Miao Wang (248377)

“…The negative contrast enhancement on <i>T</i>₂-weighted magnetic resonance images caused by the upconverting nanocrystals was increased with increasing size with the exception of the nanorods, which performed the best as <i>T</i>₂ contrast agents despite being smaller compared to the nanoplates. …”

Nucleophilicity of Oximes Based upon Addition to a Nitrilium <i>closo</i>-Decaborate Cluster by Dmitrii S. Bolotin (1953220)

“…The results of DFT calculations indicate that the mechanism for these reactions is stepwise and is realized through the formation of the orientation complex of the nitrone form, R²R³CN⁺­(H)­O^–, of oximes with [B₁₀H₉­NCEt]⁻, giving further an acyclic intermediate (the rate-determining step), followed by proton migration, leading to the addition product. …”

Nucleophilicity of Oximes Based upon Addition to a Nitrilium <i>closo</i>-Decaborate Cluster by Dmitrii S. Bolotin (1953220)

“…The results of DFT calculations indicate that the mechanism for these reactions is stepwise and is realized through the formation of the orientation complex of the nitrone form, R²R³CN⁺­(H)­O^–, of oximes with [B₁₀H₉­NCEt]⁻, giving further an acyclic intermediate (the rate-determining step), followed by proton migration, leading to the addition product. …”

Kat60 lacking the MIT domain or the MIT domain and linker region detectably colocalizes with only a few, if any, microtubules in cells. by Kyle D. Grode (725568)

<i>neurod1</i>^<i>ΔUCE</i> homozygous mutants display a decrease in the expression of several EE hormones. by Anne Sophie Reuter (12239993)

50% Reduction of dynein perturbs the movement of APP vesicles. by Gary J. Iacobucci (192833)

“…<p>(<b>A</b>) A representative movie montages from a single neuron is shown from a primary neuronal culture expressing APP-YFP in the context of 100% dynein (APP-YFP) or 50% dynein (APP-YFP; robl^K −/+). …”