Ethyl pyruvate inhibits oxidation of LDL in vitro and attenuates oxLDL toxicity in EA.hy926 cells by Christine Rossmann (4350973)

“…</p><p>Results</p><p>Oxidation of nLDL using Cu²⁺ ions was remarkably inhibited by EP in a concentration-dependent manner, reflected by decreased levels of LPO, MDA, REM, oxidation-specific epitopes, and diminished cytotoxicity of the obtained oxLDLs in EA.hy926 cells. …”

Table1_A new perspective on selenium’s impact on renal function: European population-based analysis of plasma proteome-mediated Mendelian randomization study.xlsx by Shaojie Fu (9658334)

“…</p>Methods<p>Utilizing two-sample two-step mediating mendelian randomization (MR) methodology to investigate the genetically causal relationship between selenium level and renal function as well as the role of the plasma proteome in mediating them. …”

datasheet1_Hepatic Cytochrome P450 Abundance and Activity in the Developing and Adult Göttingen Minipig: Pivotal Data for PBPK Modeling.docx by Laura Buyssens (10651334)

“…In the adult samples, sex-related differences were detected for CYP1A1, CYP1A2, CYP2A19, CYP2E1_2, CYP3A22, CYP4V2_2a and CYP4V2_2b with higher values in female compared to male Göttingen Minipigs. …”

Sequential extraction of DNA and proteins from AUP samples. by Yanbao Yu (387270)

“…The aggregate in sample #134 released DNA in a decreasing size range with each incubation step. DNase I can cleave nucleic acids to nucleosome monomers (~ 0.2 kbp). …”

Blocking interaction between phospho-cofilin and PLD1 prevents gLTP-induced spine head enlargement. by Barbara Calabrese (553229)

EARP, not GARP, is important for locomotion and trafficking dense-core vesicle cargos. by Irini Topalidou (2794261)

“…(D) IDA-1::GFP (<i>ceIs72</i> transgene) fluorescence levels in the dorsal cord. The <i>vps-50(ok2627)</i> deletion mutant had decreased IDA-1::GFP fluorescence (**, P<0.01) but the <i>vps-50(n4022)</i> late stop mutant and a <i>vps-54(ok1463)</i> deletion mutant had no decrease. …”

Open-Shell Lanthanide(II+) or -(III+) Complexes Bearing σ‑Silyl and Silylene Ligands: Synthesis, Structure, and Bonding Analysis by Rainer Zitz (1355943)

Knockdown of leptin receptor in pancreatic cancer cells leads to functional impairment of leptin signaling. by Alisha M. Mendonsa (456343)

“…<p>Long and short leptin receptor RNA levels measured through realtime PCR analysis were both significantly decreased using two different shRNAmir lentiviral titers in the Panc02 cell line (A). …”

Anthocyanin-rich compounds extracted from bilberry and blackcurrants inhibit <i>in vitro</i> osteoclastogenesis, but not osteogenesis. by Sawako Moriwaki (563407)

“…B: Anti-osteoclastogenic activity of anthocyanin compound was evaluated by the absorption ratio of the red-stained area per well at 520 nm on a spectrometer. C: Primary osteoblastic cells were cultured in the medium containing 50 µg AA, 10 µM Dex and 10 mM β-GP with or without anthocyanin compound for 2 weeks. …”

Proposed epigenetic regulatory mechanism during the somatic embryogenesis of <i>Coffea canephora</i>. by Geovanny I. Nic-Can (448043)

“…Finally, during the late developmental embryo stage, T, an increase of H3K9me2 promotes the transcriptional repression of <i>WOX4</i> and H3K27me3 again starts accumulating on <i>LEC1</i> and the expression of <i>BBM1</i> decreases. …”

Clinical and virological profiles of EVN_Term challenged vaccinated and naïve ponies. by Jodi K. Craigo (421284)

“…<p>The profiles depicted in A–I display the clinical and virological outcomes observed in EIAV_D9 vaccinated animals (<b>A–E</b>), and EIAV naïve animals (<b>F–I</b>) upon challenge with 10³ TCID₅₀ EV_NTerm chimeric proviral strain. …”

Inhibition of full-length wild-type capsid polymerization kinetics by two CA binding agents. by Magdeleine Hung (158371)

“…The dose response curves of inhibition of polymerization kinetics and the concentration of inhibitor resulting in a half-maximal inhibition (IC₅₀) for (<b>B</b>) CAI-4 and (<b>D</b>) BM2. …”

Bortezomib inhibits infectious DENV production in primary monocytes. by Milly M. Choy (790882)

“…(E) Bortezomib also inhibited 50% of virus production of the attenuated strain of yellow fever virus, YF17D, at a concentration of 0.5 nM. …”

The effect of sonication and heat treatment on the physicochemical, nutritional and microbiological properties of different sugarcane variants by Nazariah JASMI (8183856)

The K_V10.1 life cycle includes recycling of internalized channels to the plasma membrane. by Tobias Kohl (254238)

Model of the relationship between lifespan and DR protocols that reduce access to food either by intermittent exposure (left panel) or nutrient dilution (right panel). by Richard C. Grandison (375194)

DataSheet_1_Patient-Reported Outcomes-Guided Adaptive Radiation Therapy for Head and Neck Cancer.docx by Sarah Weppler (10931013)

“…Dose-PRO relationships were strongest between delivered pharyngeal constrictor Dmean and patient-reported dysphagia, with MDADI composite scores (mean ± SD) of 25.7 ± 18.9 for patients with Dmean <50 Gy vs. 32.4 ± 17.1 with Dmean ≥50 Gy. Based on logistic regression models, during-treatment dose corrections back to planned values may confer ≥5% decrease in the absolute risk of self-reported physical dysphagia symptoms ≥1 year post-treatment in 1.2% of patients, with a ≥5% decrease in relative risk in 23.3% of patients.…”

Practical facility-level approaches to reduce the malaria test positivity rate in Oyo State, Nigeria dataset.csv by Esther Oluwayemisi Ayandipo (18777193)

“…A review of the period from January to December 2021 showed a decrease in TPR from 53%-29%, compared to January to December 2022 with TPR decrease from 25%-31%. …”

Elastic fibers were disrupted via MMP in the presence of plasminogen. by Junichi Saito (4740162)

“…The blue color indicates nuclei. Scale bars, 50 μm. <b>(E)</b> Quantitative RT-PCR shows a decrease in <i>PLAT</i> mRNA expression in HUVECs transfected with <i>PLAT</i>-targeted siRNA (si PLAT 1 or si PLAT 2). n = 4, *<i>p</i> < 0.05, **<i>p</i> < 0.01. …”

Poly-3-thienylboronic Acid Nanoparticles: Synthesis, Characterization, and Interaction with Saccharides Studied at the Level of Individual Nanoparticles by Olga S. Kolosova (2350060)