siRNAs targeting IDH1. by Xi Chen (35903)

“…Two good siRNAs (-G-) and three bad siRNAs (-B-) are designed to target the IDH1 gene; all of them decrease the target gene expression by about 50%. (B–E) The relative expression levels of off-target genes predicted by Picky. …”

SIRT1 regulates the maintenance of the dendritic tree. by Juan F. Codocedo (304388)

“…Neurons were fixed at 14 DIV and immunostained against Tau protein. (<b>A</b>) Representative images of Tau immunodetection in trasfected GFP positive neurons. …”

Laccase-catalyzed iodination of different mono-methoxy-substituted phenolic compounds (structures: see Figure 2). by Julian Ihssen (417694)

“…a<p>Reaction conditions: 4 mM educt, 50 mM potassium iodide, 100 µM ABTS and 0.25 mg mL⁻¹<i>T. versicolor</i> laccase, % conversion was calculated as the relative decrease in educt peak area compared to enzyme-free control reactions.…”

Assessment of vascular density with CD31 labeling. by Deepa Sharma (278210)

“…Scale bar: 50 μm. (B) Quantification of vascularity from whole tumour sections measured from high magnification microscopy indicates a decrease in vascularity with combined treatment (570 kPa, 40 min) when compared with heat alone 0 kPa, 40 min (n = 3–5). …”

Single-leg stance center of pressure velocity. by Evangelia-Regkina Symeonidou (16378663)

“…<p>Mean mediolateral and anterior-posterior center of pressure (CoP) velocity during the single-leg stance task. Both groups showed a decrease in CoP velocity in the medio-lateral and anterior-posterior direction. …”

Normal occlusion in maturational life process by Daniela GARIB (12682165)

“…Objective: In this article, the occlusal and facial aging changes occurred during almost 50 years of follow-up are described. A normal occlusion sample from Bauru Dental School, University of São Paulo, Brazil, was evaluated at 13 (T1), 17 (T2) and 60 (T3) years of age. …”

SS-induced effects on the NB2/NB1 ratio of P1 amplitude. by Andrea S. Lowe (693855)

“…Only at 16 kHz did the post-SS ratio significantly decrease compared to the pre-SS 50 dB test (multiple comparisons significance: *<i>p</i><0.05, **<i>p</i> <0.01; ***<i>p</i> <0.01).…”

NFHp immunolabeling. by Damián Dorfman (293002)

“…In SE-housed animals, experimental diabetes induced a significant decrease in these parameters in the distal (but not proximal) ON which was prevented by EE housing. …”

Live-cell imaging of cAMP in Flamindo2/nlsFlamindo2-expressing COS7 cells. by Haruki Odaka (575909)

“…<p>(A) Representative images showing changes in fluorescence intensity (FI) by 50 µM forskolin application in Flamindo2-expressing COS7 cells. …”

Table_1_Angiotensin-I-converting enzyme inhibitory peptides from eel (Anguilla japonica) bone collagen: preparation, identification, molecular docking, and protective function on H... by Huan Xiang (460100)

“…</p>Results<p>Eel (Anguilla japonica) bone collagen was hydrolyzed by alcalase and the hydrolysate was separated into three fractions, among which the F2 displayed a higher level of ACE inhibitory activity. …”

Effect of Chain Length on the Dipole Moment of Polyisobutylene Succinate Anhydride by Minh Nguyen Vo (3374639)

Data_Sheet_1_Hypoxia signaling in the equine small intestine: Expression and distribution of hypoxia inducible factors during experimental ischemia.PDF by Nicole Verhaar (8781686)

“…Additionally, mucosal HIF1α protein levels were determined by an Enzyme Linked Immunosorbent Assay (ELISA), and mRNA levels of HIF1α and its target genes by a two-step real-time Reverse Transcriptase Polymerase Chain Reaction. …”

Data_Sheet_1_A Comparative Analysis of Reactive Müller Glia Gene Expression After Light Damage and microRNA-Depleted Müller Glia—Focus on microRNAs.pdf by Seoyoung Kang (10033280)

“…Taken together, results show there is an overlap of gene regulatory events that occur in reactive MG after light damage (direct damage of neurons) and miRNA-depleted MG (Dicer-cKO), two very different paradigms. This suggests that MG miRNAs play an important role in a ubiquitous MG stress response and manipulating these miRNAs could be a first step to attenuate gliosis.…”

Autophagy core protein ATG5 is required for elongating spermatid development, sperm individualization and normal fertility in male mice by Qian Huang (127640)

“…In <i>Atg5^flox/flox; Stra8− iCre</i> mutant mice, testicular expression of the autophagosome marker LC3A/B-II was significantly reduced, and expression of autophagy receptor SQSTM1/p62 was significantly increased, indicating a decrease in testicular autophagy activity. …”

Data_Sheet_1_A Comparative Analysis of Reactive Müller Glia Gene Expression After Light Damage and microRNA-Depleted Müller Glia—Focus on microRNAs.pdf by Seoyoung Kang (10033280)

“…Taken together, results show there is an overlap of gene regulatory events that occur in reactive MG after light damage (direct damage of neurons) and miRNA-depleted MG (Dicer-cKO), two very different paradigms. This suggests that MG miRNAs play an important role in a ubiquitous MG stress response and manipulating these miRNAs could be a first step to attenuate gliosis.…”

Igf signaling is required for cardiomyocyte proliferation during zebrafish heart development. by Ying Huang (53474)

“…E. A significant decrease (***<i>p</i><0.0001) in cardiomyocyte proliferation was detected in embryos treated with NVP-AEW541.…”

Synthesis and bioactivity of the γ-secretase modulator photo-probe AR243. by Thorsten Jumpertz (188948)

“…AR243 caused a dose-dependent decrease in Aβ42 levels with a concomitant increase in Aβ38 levels, confirming its bioactivity as a potent GSM with an IC₅₀ for Aβ42 reduction of 290 nM.…”

<b>Contrasting strategies, shared risk: 12-yr nitrogen addition compromises hydraulic safety in young and mature trees via distinct pathways</b> by Shijie Ning (17757825)

“…We found that, in young trees, N50 decreased soluble sugars in leaves, twigs, and branches, but increased in roots, suggesting a preferential belowground allocation, whereas N20 responses were limited. …”

DataSheet_6_Evaluating NetMHCpan performance on non-European HLA alleles not present in training data.csv by Thomas Karl Atkins (17791715)

“…Thus, investigating the composition of training datasets used in machine learning models with healthcare applications is vital to ensure equity. Two such machine learning models are NetMHCpan-4.1 and NetMHCIIpan-4.0, used to predict antigen binding scores to major histocompatibility complex class I and II molecules, respectively. …”

DataSheet_1_Evaluating NetMHCpan performance on non-European HLA alleles not present in training data.pdf by Thomas Karl Atkins (17791715)

“…Thus, investigating the composition of training datasets used in machine learning models with healthcare applications is vital to ensure equity. Two such machine learning models are NetMHCpan-4.1 and NetMHCIIpan-4.0, used to predict antigen binding scores to major histocompatibility complex class I and II molecules, respectively. …”