Cilia stability and structure are impaired in <i>Ttbk2</i>^{<i>sca11/gt</i>} cilia. by Emily Bowie (543704)

Potential mechanism of action of bergenin in suppressing cytokine-induced apoptosis in INS-1E cells. by Sajid Ali Rajput (9904140)

MT tip tracking of dynein-dynactin is not required for targeting the motor to the cell cortex, nor for the generation of robust cortical pulling forces. by Daniel J. Barbosa (4288462)

Dephosphorylation of AMPK by PP2A phosphatase promotes neuritogenic effect of SIM in SH-SY5Y cells. by Varshiesh Raina (457377)

“…Error bar graph shows the difference in neurite length between SIM, SIM + Fostriecin and SIM + AICAR treated cells for 12 hrs (mean ± SEM; N = 50 cells per condition from 3 separate cultures). …”

Reduced epithelial cell proliferation in Vps35^+/- cornea. by Wei Liu (20030)

Localization of IFT proteins is perturbed in <i>Ttbk2</i> hypomorphic alleles. by Emily Bowie (543704)

RNS60 treatment decreased expression of hypoxia inducible factor 1α (HIF1α) in the peri infarct cortical area of tMCAo mice 4 days after onset of daily dose of RNS60. by Gloria Patricia Baena-Caldas (17721328)

Data Sheet 1_Isoform-specific vs. pan-histone deacetylase inhibition as approaches for countering glioblastoma: an in vitro study.docx by Ameya Joshi (1290186)

“…We characterized the effect of the 3D half-maximal inhibitory concentrations (IC50) on spheroids using a live–dead assay to figure out which inhibitors inhibited cell viability in 3D the most. …”

The number of Brn3a-expressing RGCs undergoes a reduction during the first postnatal week. by Sylvie Voyatzis (332702)

“…The inner surface of the retina (RGC layer) is down. The density of Brn3a-expressing cells decreases from P0 to P7 and the retinal ganglion cell layer reorganizes from a multiple cell layer at P0 to a single cell layer at P7. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Fig 7 - by B. Ulfhake (6293984)

Fig 8 - by B. Ulfhake (6293984)

Fig 6 - by B. Ulfhake (6293984)