N-terminal huntingtin fragments in control temporal cortex tissue from an individual subject. by Menno H. Schut (4060249)

3D model of the compressor. by Jingya Dong (19959282)

Proteomic Profiling in <i>Drosophila</i> Reveals Potential Dube3a Regulation of the Actin Cytoskeleton and Neuronal Homeostasis by Laura Jensen (405470)

“…<div><p>The molecular defects associated with Angelman syndrome (AS) and 15q duplication autism are directly correlated to expression levels of the E3 ubiquitin ligase protein UBE3A. Here we used <i>Drosophila melanogaster</i> to screen for the targets of this ubiquitin ligase under conditions of both decreased (as in AS) or increased (as in dup(15)) levels of the fly Dube3a or human UBE3A proteins. …”

Data_Sheet_1_Ribozyme-Mediated Downregulation Uncovers DNA Integrity Scanning Protein A (DisA) as a Solventogenesis Determinant in Clostridium beijerinckii.pdf by Victor Chinomso Ujor (10939044)

“…Unexpectedly, C. beijerinckii_M1GS^CcpA–Sc produced 50% more solvent than C. beijerinckii_pMTL500E grown on glucose + arabinose. …”

DataSheet_2_Immunotherapeutic Effects of Different Doses of Mycobacterium tuberculosis ag85a/b DNA Vaccine Delivered by Electroporation.pdf by Yan Liang (139654)

“…</p>Methods<p>Ninety-six female BALB/c mice were challenged with 2×10⁴ colony-forming units (CFUs) of MTB H₃₇Rv through tail vein injection, then was treated with 10μg, 50μg, 100μg, and 200μg of Mycobacterium tuberculosis (MTB) ag85a/b chimeric DNA vaccine delivered by intramuscular injection (IM) and electroporation (EP), respectively. …”

DataSheet_1_Immunotherapeutic Effects of Different Doses of Mycobacterium tuberculosis ag85a/b DNA Vaccine Delivered by Electroporation.pdf by Yan Liang (139654)

“…</p>Methods<p>Ninety-six female BALB/c mice were challenged with 2×10⁴ colony-forming units (CFUs) of MTB H₃₇Rv through tail vein injection, then was treated with 10μg, 50μg, 100μg, and 200μg of Mycobacterium tuberculosis (MTB) ag85a/b chimeric DNA vaccine delivered by intramuscular injection (IM) and electroporation (EP), respectively. …”

DCP-LA treatment of SN56 cells diverts APP into early endosome compartments. by Joshua H. K. Tam (836784)

Mutational landscape of TCL cell lines. by Rufino Mondejar (4025846)

Effectiveness of community-based complementary food supplement (Yingyangbao) distribution in children aged 6-23 months in poor areas in China by Jie Wang (16762)

“…Compared with the baseline situation (n = 823), the proportion of children fed a diverse diet and foods rich in iron or vitamin A increased (<i>P</i> < 0.01) in the follow-up study. …”

Difficulty as a function of the level. by Federico Zimmerman (3607586)

Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells by Magdalena Circu (4458754)

“…We investigated whether triggering lysosomal membrane permeabilization (LMP) or suppressing autophagy can restore cisplatin susceptibility in lung cancer with acquired chemoresistance. Cisplatin IC₅₀ in A549Pt (parental) and A549cisR (cisplatin resistant) cells was 13 μM and 47 μM, respectively. …”

Poly (A) Binding Protein Cytoplasmic 1 Is a Novel Co-Regulator of the Androgen Receptor by Kurtis Eisermann (95302)

“…Co-immunoprecipitation assays confirmed the association of PABPC1 with a.a. 50-250 of the NTD of the AR. Knockdown of PABPC1 decreased nuclear AR protein levels and inhibited androgen activation of the AR target PSA in LNCaP and C4-2 cells. …”

GO annotation analyses of DEGs. by Benzun Wei (21485639)

Soluble lytic transglycosylase SLT of <i>Francisella novicida</i> is involved in intracellular growth and immune suppression by Takemasa Nakamura (8190540)

Tyrosine motif mutations affect on APP/AP-3 interaction. by Joshua H. K. Tam (836784)

⁶⁸Ga-Labeled TMTP1 Derivatives with Moderate Hydrophilicity for Positron Emission Tomography of Hepatocellular Carcinoma in High Contrast by Xiaowei Fan (10198883)

“…Subnanomolar and nanomolar affinities comparable to the non-PEGylated TMTP1 derivative were revealed by the IC₅₀ values in SMMC-7721 cells. [⁶⁸Ga]Ga-NOTA-PEG₂-TMTP1 presented a significantly higher tumor/liver ratio (4.19 ± 0.54, at 30 min post intravenous injection) and tumor/muscle ratio (2.14 ± 0.17) compared to the others and the previously radiolabeled TMTP1 derivatives. …”

Effect of fenretinide and its metabolites on SCD expression and activity. by Eugenia Poliakov (116500)

“…<p>A) SCD1 protein expression is decreased after treatment with fenretinide, and its metabolite 3-keto-HPR. …”

Loss of PRC2 activity leads to changes in DNA methylation. a, by James A. Hagarman (104059)

“…<b>f,</b> Gene ontology classifications for genes with increased (red) or decreased (green) DNAme. <b>g,</b> Gene ontology classifications for genes with increased DNAme upstream of the TSS (cluster 1, white) or across the entire promoter (cluster 2, grey). …”

Contour plot of thresholds to achieve national and ambitious targets with varying levels of management cost reductions and treatment cost reductions. by Andrew J. Shattock (720510)

“…The ‘no increase’ contour is the threshold for satisfying the national targets (and is hence the border for the light grey region), whilst the ‘50% decrease’ contour satisfies the ambitious targets (and is hence the border for the dark grey region). …”

All naive T cells undergo turnover throughout adult life. by Jeff E. Mold (7571855)