Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…XZB108, selectively inhibited HDAC8 (IC₅₀ = 0.90 ± 0.014 μM), suggesting that it may be a promising nonhydroxamate HDAC8 inhibitor. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…XZB108, selectively inhibited HDAC8 (IC₅₀ = 0.90 ± 0.014 μM), suggesting that it may be a promising nonhydroxamate HDAC8 inhibitor. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…XZB108, selectively inhibited HDAC8 (IC₅₀ = 0.90 ± 0.014 μM), suggesting that it may be a promising nonhydroxamate HDAC8 inhibitor. …”

Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments by Stefania Ferro (76724)

“…The inhibition of tyrosinase (Ty, EC 1.14.18.1) represents an efficient strategy of decreasing melanogenesis and skin hyperpigmentation. …”

Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies by Brianna D. Mackie (9212677)

“…Its cell-permeable analogue <b>DC432</b> (IC₅₀ of 54 ± 4 nM) decreases the N-terminal methylation level of the regulator of chromosome condensation 1 and SET proteins in HCT116 cells. …”

Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes by Wipawee Wongchana (5367968)

“…A similar impact on IL-10 production was observed when Notch signaling was inhibited with a gamma-secretase inhibitor (GSI). …”

Effects of GSI treatment on MAPK, PI3K/AKT and NF-κB pathway activation in LPS/IC-activated macrophages. by Wipawee Wongchana (5367968)

“…The arrows indicate cells with decreased or no p50 nuclear translocation (green). …”

Liquid cultures in RPMI-1640. by Nicholas C. Schena (16541975)

CgA silencing, processing enzyme inhibition and functional analysis of CgA peptides in SI-NEN cell lines. by Francesco Giovinazzo (487256)

“…Inhibition of the CgA processing enzyme prohormone convertase using Decanoyl-Arg-Val-Lys-Arg-CMK also decreased proliferation of H-STS cells (25 µM [<i>data not shown</i>] and 50 µM, <b>4D</b>, *<i>p</i><0.05). …”

Phase Behavior and Self-Assembly of Semiflexible Polymers in Poor-Solvent Solutions by Tobia Arcangeli (19540447)

Evaluation of Efficiency of Liposome-Entrapped Iridium(III) Complexes Inhibiting Tumor Growth In Vitro and In Vivo by Huiyan Hu (9376570)

“…Surprisingly, its liposome-entrapped complexes 3alip, 3blip, and 3clip on B16 cells showed strong cytotoxicity (IC₅₀ = 13.6 ± 2.8, 9.6 ± 1.1, and 18.9 ± 2.1 μM). …”

Regulation of Motility of Myogenic Cells in Filling Limb Muscle Anlagen by Pitx2 by Adam L. Campbell (167812)

“…The regulatory mechanisms that control the later steps of this myogenic program are not well understood. …”

CDK2/Speedy A localization in <i>Cdk2</i>^<i>T160A</i> spermatocytes. by Nathan Palmer (264897)

“…Data are presented as individual foci counts for WT (orange bars, N = 72) and <i>Cdk2</i>^<i>T160A</i> (blue bars, N = 50); error bars are indicative of the mean and SD. …”

Estimated numbers of people aged 65+ years living with dementia under various scenarios and difference to ageing-only scenario. by Binod Nepal (625271)

Fig 1 - by Gilda Cennamo (448296)

“…</b> Left eye of a patient (50 years-old female) with pitituary adenoma before surgery reveals a reduction of vessel density in SCP (A1), DCP (B1), RPC (C1) and an increase of FAZ area (D1) respect to healthy subject. …”

B6 <i>mA3</i> is a saturable innate restriction factor <i>in vivo</i>. by Diana S. Smith (176104)

Fig 5 - by Maryam Banar (3220221)

Examples of dynamic response of g_s and A_max after detachment of the leaf (A: calculation of the dynamic parameters in a leaf with 0% visible injury, B: time c... by Yasutomo Hoshika (319347)

HCV RNA was quantified by RT-QPCR after infection in stable cell lines. by Sobia Manzoor (11372369)

Cashtags become substantially more popular after Musk purchased X. by Daniel Hickey (20714822)