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step decrease » sizes decrease (Expand Search), we decrease (Expand Search)
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7181
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7182
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7183
Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo
Published 2016“…Among them, <b>14k</b> exhibited most potent activity, with IC<sub>50</sub> values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”
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7184
Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo
Published 2016“…Among them, <b>14k</b> exhibited most potent activity, with IC<sub>50</sub> values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”
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7185
Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo
Published 2016“…Among them, <b>14k</b> exhibited most potent activity, with IC<sub>50</sub> values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”
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7186
Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo
Published 2016“…Among them, <b>14k</b> exhibited most potent activity, with IC<sub>50</sub> values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”
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7187
Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo
Published 2016“…Among them, <b>14k</b> exhibited most potent activity, with IC<sub>50</sub> values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”
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7188
Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo
Published 2016“…Among them, <b>14k</b> exhibited most potent activity, with IC<sub>50</sub> values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”
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7189
Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo
Published 2016“…Among them, <b>14k</b> exhibited most potent activity, with IC<sub>50</sub> values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”
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7190
Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo
Published 2016“…Among them, <b>14k</b> exhibited most potent activity, with IC<sub>50</sub> values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”
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7191
Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo
Published 2016“…Among them, <b>14k</b> exhibited most potent activity, with IC<sub>50</sub> values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”
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7192
Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo
Published 2016“…Among them, <b>14k</b> exhibited most potent activity, with IC<sub>50</sub> values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”
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7193
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7194
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7195
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7196
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7197
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7198
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7199
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7200
PPM1A facilitates both nuclear distribution and transcription potency of YAP/TAZ.
Published 2021“…<b>(B–D)</b> Transcription potency of YAP (5 ng), which was suppressed by coexpression of MST1 (50 ng) (B), LATS1 (500 ng) (C), or MAP4K1 (50 ng) (D), was markedly recovered by cotransfection of wild-type PPM1A but not the enzyme-dead PPM1A (D239N). …”