Bioassay and NMR-HSQC-Guided Isolation and Identification of Phthalide Dimers with Anti-Inflammatory Activity from the Rhizomes of Angelica sinensis by Hongyan Wen (9226895)

“…Among them, compound <b>9</b> showed a remarkable inhibitory activity with IC₅₀ values of 425 nM and could significantly decrease IL-1β and IL-6 transcription levels. …”

Platinum-Based Modification of Styrylbenzylsulfones as Multifunctional Antitumor Agents: Targeting the RAS/RAF Pathway, Enhancing Antitumor Activity, and Overcoming Multidrug Resis... by Zhikun Liu (389939)

“…Among them, compound <b>29</b> showed the most potent antitumor activity in vitro with IC₅₀ values at the nanomolar level against the tested tumor cell lines and 1000-fold higher than cisplatin against the multidrug resistant cells (A549/CDDP, A549/DOX, and SKOV-3/CDDP cells), while it showed only moderate cytotoxicity against normal cells (HEUVC cells). …”

Validation of selected genes associated with p53 connection pathway was carried out using quantitative real-time polymerase chain reaction (qRT-PCR) and western immunoblotting. by Mei Yi Sim (4067998)

A Membrane-bound eIF2 Alpha Kinase Located in Endosomes Is Regulated by Heme and Controls Differentiation and ROS Levels in <i>Trypanosoma cruzi</i> by Leonardo da Silva Augusto (195970)

“…This occurs by the activation of protein kinases that phosphorylate the alpha subunit of the translation initiation factor 2 (eIF2α), which decreases translation, and in higher eukaryotes favors the expression of stress remedial response genes. …”

Tuning Magnetic and Structural Transitions through Valence Electron Concentration in the Giant Magnetocaloric Gd_5–<i>x</i>Eu_<i>x</i>Ge₄ Phases by Jinlei Yao (1712740)

“…A decrease in the valence electron concentration achieved through the substitution of Eu²⁺ for Gd³⁺ leads to the formation of the interslab Ge–Ge dimers, phase transitions to the Gd₅Si₂Ge₂- and Gd₅Si₄-type structures, and a ferromagnetic ordering in the Gd_5–<i>x</i>Eu_<i>x</i>Ge₄ system. …”

Image_1_EGTA Can Inhibit Vesicular Release in the Nanodomain of Single Ca2+ Channels.JPEG by Yukihiro Nakamura (735502)

“…In proximity to a channel, the vesicular sensor is often saturated for a long voltage step, but not for a brief Ca²⁺ influx typically evoked by an action potential. …”

Distinct Patterns of IgG and IgA against Food and Microbial Antigens in Serum and Feces of Patients with Inflammatory Bowel Diseases by Lisa Frehn (629123)

Solvent accessible surface area. by Jingran Wen (4047724)

Solvent-polyQ hydrogen bond count. by Jingran Wen (4047724)

Solvent-polyQ hydrogen bond count at the atomic level. by Jingran Wen (4047724)

Intra-polyQ hydrogen bonding. by Jingran Wen (4047724)

IgG Fc-binding motif-conjugated HIV-1 fusion inhibitor exhibits improved potency and <i>in vivo</i> half-life: Potential application in combination with broad neutralizing antibodi... by Wenwen Bi (8086730)

“…The newly engineered peptide IBP-CP24 exhibited potent and broad anti-HIV-1 activity with IC₅₀ values ranging from 0.2 to 173.7 nM for inhibiting a broad spectrum of HIV-1 strains with different subtypes and tropisms, including those resistant to enfuvirtide. …”

BRSV RNA detected in nasal swabs of cows that were naturally re-infected four years after a previous natural BRSV infection (n = 7, reinfection) and cows that were naturally infect... by Sara Hägglund (580500)

Data_Sheet_3_Exploring the active ingredients and pharmacological mechanisms of the oral intake formula Huoxiang Suling Shuanghua Decoction on influenza virus type A based on netwo... by Ruying Tang (14036640)

Data_Sheet_14_Exploring the active ingredients and pharmacological mechanisms of the oral intake formula Huoxiang Suling Shuanghua Decoction on influenza virus type A based on netw... by Ruying Tang (14036640)

Data_Sheet_2_Exploring the active ingredients and pharmacological mechanisms of the oral intake formula Huoxiang Suling Shuanghua Decoction on influenza virus type A based on netwo... by Ruying Tang (14036640)

Number of intra-polyQ hydrogen bonds vs. the number of solvent-polyQ hydrogen bond. by Jingran Wen (4047724)

Secondary structure of polyQ fragments of different lengths. by Jingran Wen (4047724)

CONSORT diagram. by Aurélie Chabanon (5562944)

Mitochondrial proteins <i>in situ</i> tagged with BioID2. by Jan Pyrih (229124)