Table_1_Effect of nationwide reimbursement of real-time continuous glucose monitoring on HbA1c, hypoglycemia and quality of life in a pediatric type 1 diabetes population: The RESC... by Francesca De Ridder (7333049)

“…</p>Results<p>Between December 2014 and February 2019, 75 children/adolescents were followed for 12 (n = 62) and 24 months (n = 50). Baseline HbA1c was 7.2 ± 0.7% (55 ± 8mmol/mol) compared to 7.1 ± 0.8% (54 ± 9mmol/mol) at 24 months (p = 1.0). …”

Table_1_Impact of traditional Chinese Baduanjin exercise on menstrual health among international female students studying in China: a randomized controlled trial.DOC by Asem Alkhatib (11244708)

“…In addition, the results of the MANOVA indicated statistically significant decreases in scores for the two subscales of MSQ: premenstrual symptoms (intervention: 17.07 ± 3.33 vs. control: 28.42 ± 7.56; F = 44.70, P < 0.01)and menstrual pain (16.03 ± 4.53 vs. 19.58 ± 5.14; F = 6.50, P < 0.05). …”

Brain-specific deletion of <i>Mef2a</i> and <i>Mef2d</i> causes impairments in motor coordination, as well as presynaptic release probability. by M. Waseem Akhtar (326982)

“…(<b>H</b>) Paired-pulse facilitation is increased in <i>Mef2a/d</i>^DKO mice at Inter-Stimulus Interval 20, 30, 50, 100, 200 and 400 (mS) compared to littermate CTLs, suggesting decreased presynaptic release probability (CTL, n=8; <i>Mef2a/d</i>^DKO, n=7). …”

Down-regulation in antimicrobial and absorption expression programs. by Noam Cohen (319186)

“…Black dashed lines represent mean values; white dots represent median values of 5 repeats of at least 3 individual FAE from 2 mice. …”

Bacterial PAMPs (LPS) and cytokines (IFNγ) increase macrophage phagocytosis and cell elasticity. by Naimish R. Patel (136156)

“…</b> Macrophage elasticity is decreased by actin polymerization inhibitor. Optical Magnetic Twisting Cytometry (OMTC) measurement of RAW macrophages cultured on more rigid (150 kPa) surface and treated with the myosin inhibitor blebbistatin (Bleb, 50 µM) or the actin polymerization inhibitor latrunculin A (Lat A, 1 µM). …”

Image_3_The Association Between Alveolar Dead Space Fraction and Mortality in Pediatric Acute Respiratory Distress Syndrome: A Prospective Cohort Study.TIF by Sheow Boon Oh (12157812)

“…The high AVDSF group had higher mortality [7/19 (36.8%) vs. 5/50 (10.0%); p = 0.009] and lower VFD [2 (0, 18) vs. 21 (15, 24); p = 0.007] and IFD [0 (0, 16) vs. 16 (5, 21); p = 0.013]. …”

Table_1_Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2.xlsx by Christian Klemann (3779056)

“…Cohort analysis extended to all 35 previously published NFKB2-cases revealed occurrence of early-onset PID in 46/50 patients (mean age of onset 5.9 years, median 4.0 years). …”

FIGURE 1 from Remodeling of Stromal Immune Microenvironment by Urolithin A Improves Survival with Immune Checkpoint Blockade in Pancreatic Cancer by Siddharth Mehra (15666660)

“…<b>H,</b> Cytokine array profiling of pancreatic tumor tissues harvested from PKT mice treated with Uro A or vehicle. Scale bar = 50 μm. Individual datapoints with mean ± SEM are shown and compared by two-tailed unpaired <i>t</i> test for two group comparison and one-way ANOVA for multiple comparisons; *, <i>P</i> < 0.05; **, <i>P</i> < 0.01; ***, <i>P</i> < 0.001; ^ns, <i>P</i> > 0.05.…”

Fluorescence time-lapse imaging of a single GPR3-HT-expressing CGN. by Tatsuhiro Miyagi (847543)

“…The cells were treated with 1 μM Latrunculin B, 3 μM Nocodazole, 50 μM Blebbistatin, or 2 mM Monastrol in the culture medium, respectively. …”

Acute effect of timolol on intracellular global Ca²⁺ changes, and the basal levels of intracellular both free Zn²⁺ and Ca²⁺ in ventricular hypergly... by Erkan Tuncay (438815)

“…(C) To record basal levels of both intracellular free Zn²⁺ and Ca²⁺ in resting cells in parallel, we used a ratiometric Fura-2 (4-µM Fura-2 AM) loaded cells and 50-µM N,N,N′,N′-tetrakis (2-pyridylmethyl) ethylenediamine (TPEN) (for more information about methods, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071014#pone.0071014-Tuncay1" target="_blank">[28]</a>). …”

Knockdown of CRT suppressed VEGF-A expression and mRNA stability through ARE in AGS cells. by Po-Chu Lee (438366)

“…VEGF-A mRNA was significantly less stable in the CRT-knockdown cells with lower half-life and 50% mRNA remaining time. The remaining amount of VEGF-A mRNA in the CRT-knockdown cells was significantly decreased at 60 and 90 minutes compared to that in the control cells. …”

The effect of the PI3K inhibitor LY294002 (LY) on the cell viability and the [Ca²⁺]_i of primary cultured SD rat retinal cells in H₂O₂ in... by Yan Feng (128912)

“…<p>A: Western blot results of the activation of the PI3K/Akt pathway after βE2 treatment for 0.5 hrs; B: Quantitative data of A; C, E, G, and I: Cell viability quantitative data; D, F, H, and J: [Ca²⁺]_i quantitative data; C and D: The effects of LY treatments for 24 hrs and 0.5 hrs on the cell viability and the resting [Ca²⁺]_i; E and F: The inhibitory effect of LY pretreatment for 0.5 hrs on the increased cell viability and [Ca²⁺]_i induced by 10 μM βE2 treatment for 0.5 hrs (10 μM LY in E, 10 μM and 20 μM LY in F); G and H: The effect of LY pretreatment for 0.5 hrs on the decreased cell viability and increased [Ca²⁺]_i induced by 100 μM H₂O₂ treatment for 2 hrs (10 μM LY in G, 10 μM and 20 μM LY in H); I and J: The dose-dependent attenuating impact of 20-50 μM LY pretreatment for 0.5 hrs on the βE2 retinal protective role against H₂O₂ injury, which is associated with the dose-dependent attenuation of the increased [Ca²⁺]_i (Protocol of drug application: LY for 0.5 hrs, E2 for 0.5 hrs and H₂O₂ for 2 hrs). …”

Treatment with a muscarinic receptor agonist, acetylcholine (ACh), alters the expression of microRNAs (miRs) in human colon cancer cells. by Shannon M. Larabee (12770415)

Automated detection of moderate and large pneumothorax on frontal chest X-rays using deep convolutional neural networks: A retrospective study by Andrew G. Taylor (5993075)

“…Using an internal validation set (<i>n</i> = 1,993), we selected the 2 top-performing models; these models were then evaluated on a held-out internal test set based on area under the receiver operating characteristic curve (AUC), sensitivity, specificity, and positive predictive value (PPV). …”

Data_Sheet_1_Genetically predicted serum metabolites mediate the association between inflammatory proteins and polycystic ovary syndrome: a Mendelian randomization study.CSV by Ming-Jie Jia (18267391)

“…This analysis involved genetically predicted PCOS (1,639 cases and 218,970 controls) and inflammatory proteins (14,824 participants of primarily European descent). Additionally, a two-step MR analysis was performed to quantify the proportion of the effect of serum metabolites-mediated inflammatory proteins on PCOS. …”

Entropy optimization and stability analysis in flow of quadratic radiative <i>Ag−MgO</i>/<i>water</i> hybrid micropolar nanofluid over an exponentially contracting permeable Riga s... by Gopinath Mandal (17767951)

“…Such endeavors are crucial steps towards fostering more efficient and sustainable industrial practices, aligning with the overarching objectives of enhancing energy utilization and promoting industrial growth.…”

Analysis of the bistable behavior of RMD neuron. by Martina Nicoletti (6900464)

“…At lower values of , and by decreasing the parameter, two unstable solutions and arise from a LP bifurcation (LP-H), with . …”

Soluble HLA-DR alpha 2 domain inhibits IFN-γ cytokine expression and phosphorylation of STAT4, but not STAT6. by Grit-Carsta Bulwin (75307)

“…The results shown represent the means of five independent experiments, respectively. …”

Image_1_Assessment of causal associations between uric acid and 25-hydroxyvitamin D levels.tif by Yingdong Han (11904761)

“…MR analyses were also conducted using genetic risk scores (GRS) as instrumental variables in both directions by using the same summary-level GWAS data.</p>Results<p>Our two-sample MR analysis suggested a causal association of genetically predicted uric acid on 25-hydroxyvitamin D [IVW method: β(SE), −0.0352(0.0149); p = 0.0178], which suggested that a per mg/dl increase in uric acid was associated with a decrease of 0.74 nmol/L of 25-hydroxyvitamin D, and the above results remained stable in the sensitivity analysis. …”

DataSheet_1_Assessment of causal associations between uric acid and 25-hydroxyvitamin D levels.pdf by Yingdong Han (11904761)

“…MR analyses were also conducted using genetic risk scores (GRS) as instrumental variables in both directions by using the same summary-level GWAS data.</p>Results<p>Our two-sample MR analysis suggested a causal association of genetically predicted uric acid on 25-hydroxyvitamin D [IVW method: β(SE), −0.0352(0.0149); p = 0.0178], which suggested that a per mg/dl increase in uric acid was associated with a decrease of 0.74 nmol/L of 25-hydroxyvitamin D, and the above results remained stable in the sensitivity analysis. …”