Showing 7,801 - 7,820 results of 31,172 for search '(( 2 step decrease ) OR ( 50 ((((we decrease) OR (mean decrease))) OR (a decrease)) ))', query time: 1.20s Refine Results
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    Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

    Published 2021
    “…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC<sub>50</sub> < 200 nM). …”
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    Enhanced pyruvate dehydrogenase activity improves cardiac outcomes in a murine model of cardiac arrest by Lin Piao (4452487)

    Published 2017
    “…In both heart and brain, CA increased lactate concentrations (1.9-fold and 3.1-fold increase, respectively, <i>P</i><0.01), decreased PDH enzyme activity (24% and 50% reduction, respectively, <i>P</i><0.01), and increased PDK protein expressions (1.2-fold and 1.9-fold, respectively, <i>P</i><0.01). …”
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    Neurally mediated syncope diagnosis based on adenylate cyclase activity in Japanese patients - Fig 3 by Tomoyoshi Komiyama (474366)

    Published 2019
    “…B: Isoproterenol was decreased by 5 mM for each 1/10 at the following concentrations: 5 nM, 50 nM, 500 nM, 5 μM, 50 μM, 500 μM, and 5 mM. …”
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    DN dynamin II (K44A) slows down endocytosis of KCa2.3. by Yajuan Gao (309862)

    Published 2013
    “…<p><b>A.</b> BLAP-KCa2.3 was co-expressed with either WT or K44A dynamin II and cell surface expression of the channel evaluated in triplicate as detailed in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044150#s2" target="_blank">Methods</a> (top panel). …”
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