Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Relationships between each parameter relative change and stent wire mesh density. by Shunsuke Masuda (12859231)

PRISMA flow diagram. by Apoorva Anand (17921197)

“…Lower sensitivity was attributed to absence of symptoms, errors in test conduct and absence of supervision or a digital support. We found no difference in COVIDST sensitivity between delta and omicron pre-dominant period. …”

An Allosteric Modulator of RNA Binding Targeting the N‑Terminal Domain of TDP-43 Yields Neuroprotective Properties by Niloufar Mollasalehi (9511076)

“…<i>In silico</i> docking of 50K compounds to the NTD domain of TDP-43 identified a small molecule (nTRD22) that is bound to the N-terminal domain. …”

Meta-analyses of COVIDST diagnostic accuracy. by Apoorva Anand (17921197)

“…Lower sensitivity was attributed to absence of symptoms, errors in test conduct and absence of supervision or a digital support. We found no difference in COVIDST sensitivity between delta and omicron pre-dominant period. …”

Thalamic DBS modulates VPC occurrence over acute and longer time frames. by Michelle J. Redinbaugh (13029044)

Results of t-tests comparing nutrient supply rates (micrograms / 10cm² / burial length) in sterilized versus live soil, in seedling pots. by Katherine E. A. Wood (17325907)

This figure shows the results for 200 epochs at each lookback starting from 1 to 500. by Muhammad Muneeb (3244095)

Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier Bricks by Sofia Benfeito (4345591)

“…Although the lipophilic triphenylphosphonium (TPP⁺) cation is widely used to target antioxidants to mitochondria, TPP⁺-based derivatives have shown cytotoxicity in several biological <i>in vitro</i> models. We confirmed that <b>Mito.TPP</b> is cytotoxic to both human neuronal (SH-SY5Y) and hepatic (HepG2) cells, decreasing intracellular adenosine triphosphate (ATP) levels, leading to mitochondrial membrane depolarization and reduced mitochondrial mass after 24 h. …”

Proportional symbol map of arsenic (As) in micrograms per liter (μg/L) in Bangladesh’s drinking well water. by Seth H. Frisbie (7821866)

S2 Fig - by Linda Karoline Dämmer (16839021)

Video_2_Characterization of tmt-opsin2 in Medaka Fish Provides Insight Into the Interplay of Light and Temperature for Behavioral Regulation.MP4 by Theresa Zekoll (9955507)

“…However, detailed analyses of fish position revealed that the tmt-opsin2 mutants spent more time in central locations of the dish, possibly because of decreased anxiety. …”

Understanding and Improving the Kinetics of Bulk Carbonation on Sodium Carbonate by Tianyi Cai (1511026)

“…We find that the kinetics of Na₂CO₃ bulk carbonation is controlled by the <i>I</i>_H⁺/<i>V</i>_Na^– defect pair generation in Na₂CO₃; we predict that the kinetics can be enhanced by doping lithium into Na₂CO₃, which decreases the defect formation energy by 0.13 eV. …”

Understanding and Improving the Kinetics of Bulk Carbonation on Sodium Carbonate by Tianyi Cai (1511026)

“…We find that the kinetics of Na₂CO₃ bulk carbonation is controlled by the <i>I</i>_H⁺/<i>V</i>_Na^– defect pair generation in Na₂CO₃; we predict that the kinetics can be enhanced by doping lithium into Na₂CO₃, which decreases the defect formation energy by 0.13 eV. …”

Understanding and Improving the Kinetics of Bulk Carbonation on Sodium Carbonate by Tianyi Cai (1511026)

“…We find that the kinetics of Na₂CO₃ bulk carbonation is controlled by the <i>I</i>_H⁺/<i>V</i>_Na^– defect pair generation in Na₂CO₃; we predict that the kinetics can be enhanced by doping lithium into Na₂CO₃, which decreases the defect formation energy by 0.13 eV. …”

Understanding and Improving the Kinetics of Bulk Carbonation on Sodium Carbonate by Tianyi Cai (1511026)

“…We find that the kinetics of Na₂CO₃ bulk carbonation is controlled by the <i>I</i>_H⁺/<i>V</i>_Na^– defect pair generation in Na₂CO₃; we predict that the kinetics can be enhanced by doping lithium into Na₂CO₃, which decreases the defect formation energy by 0.13 eV. …”

Understanding and Improving the Kinetics of Bulk Carbonation on Sodium Carbonate by Tianyi Cai (1511026)

“…We find that the kinetics of Na₂CO₃ bulk carbonation is controlled by the <i>I</i>_H⁺/<i>V</i>_Na^– defect pair generation in Na₂CO₃; we predict that the kinetics can be enhanced by doping lithium into Na₂CO₃, which decreases the defect formation energy by 0.13 eV. …”