Mixed Ligand Copper(II) Complexes of <i>N</i>,<i>N</i>-Bis(benzimidazol-2-ylmethyl)amine (BBA) with Diimine Co-Ligands: Efficient Chemical Nuclease and Protease Activities and Cyto... by Rangasamy Loganathan (2081950)

“…The highest efficiency of <b>3</b> to cleave both DNA and protein in the presence of H₂O₂ is consistent with its strong hydrophobic interaction with the biopolymers. The IC₅₀ values of <b>1</b>–<b>4</b> against cervical cancer cell lines (SiHa) are almost equal to that of cisplatin, indicating that they have the potential to act as effective anticancer drugs in a time-dependent manner. …”

DataSheet1_Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disord... by Johannes Matthaei (3534620)

“…In a second, independent study sample of 50 patients who underwent amitriptyline therapy of 75 mg twice daily, a significant trend of increasing amitriptyline plasma concentrations with decreasing OCT1 activity was observed (p = 0.018), while nortriptyline plasma concentrations were unaffected by the OCT1 genotype. …”

Glucose-Dependent Insulin Secretion in Pancreatic β-Cell Islets from Male Rats Requires Ca²⁺ Release via ROS-Stimulated Ryanodine Receptors by Paola Llanos (750250)

“…We propose that RyR2-mediated Ca²⁺ release, induced by the concomitant increases in [Ca²⁺] and ROS produced by stimulatory glucose, is an essential step in GSIS.…”

Self-renewal and differentiation of neural stem/progenitor cells. by Qingfa Chen (739620)

“…Error bars represent SD. Scale bars, 50 μm. <b>K and L,</b> Neurosphere formation from cortical cells isolated from <i>Nestin;Epha4</i>^<i>fx/fx</i> cortex in the presence of FGF2 alone, clustered ephrin-A1 alone, or FGF2 plus clustered ephrin-A1. …”

Schematic representation of the study protocol. by Neng Pan (5262032)

Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells by Magdalena Circu (4458754)

“…Cisplatin IC₅₀ in A549Pt (parental) and A549cisR (cisplatin resistant) cells was 13 μM and 47 μM, respectively. …”

Canonical correspondence analysis of mosquito assemblages and landscape structure classifications at each sampling unit. by Leonardo Suveges Moreira Chaves (5554235)

Soluble lytic transglycosylase SLT of <i>Francisella novicida</i> is involved in intracellular growth and immune suppression by Takemasa Nakamura (8190540)

Principal components dimensions showed in PCA. by Leonardo Suveges Moreira Chaves (5554235)

TG-DTG curves at different heating rates. by Meihui Wu (8586993)

Data_Sheet_1_HMG-Coenzyme A Reductase as a Drug Target for the Prevention of Ankylosing Spondylitis.docx by Zhenyu Zhong (6861935)

“…No significant association with ankylosing spondylitis was observed for the PCSK9 score (OR, 0.89; 95% CI, 0.68–1.16) and the NPC1L1 score (OR, 1.50; 95% CI, 0.39–5.77). For the LDL score, genetically determined per mmol/L decrease in LDL cholesterol levels led to a reduced risk of ankylosing spondylitis (OR, 0.64; 95% CI, 0.43–0.94), with significant heterogeneity and pleiotropy in the estimate. …”

Pandemic Influenza A Viruses Escape from Restriction by Human MxA through Adaptive Mutations in the Nucleoprotein by Benjamin Mänz (369793)

Fig 5 - by Leonardo Suveges Moreira Chaves (5554235)

Intramyocellular triacylglycerol accumulation across weight loss strategies; Sub-study of the CENTRAL trial by Yftach Gepner (4633801)

A simplified visualization of a patient’s healthcare timeline. by Mohamed Abdalla (10100115)

Two different models of secretion. A. Sequential Pool Model (SPM). by Alexander M. Walter (493797)

“…A Michaelis-Menten Ca²⁺-dependent step fills the NRP from the Depot Pool (recruitment, brown background). …”

Fig 3 - by Yan Shu (441370)

Image_8_2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression.JPEG by Wen-I Liao (586146)

Image_6_2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression.JPEG by Wen-I Liao (586146)

Image_7_2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression.JPEG by Wen-I Liao (586146)