N-terminal huntingtin fragments in control temporal cortex tissue from an individual subject. by Menno H. Schut (4060249)

3D model of the compressor. by Jingya Dong (19959282)

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…In this work, we reported the structure-based design of triazolo­[1,5-<i>a</i>]­pyrimidines as new ABCB1 modulators, of which <b>WS-691</b> significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC₅₀ = 22.02 nM). …”

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…In this work, we reported the structure-based design of triazolo­[1,5-<i>a</i>]­pyrimidines as new ABCB1 modulators, of which <b>WS-691</b> significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC₅₀ = 22.02 nM). …”

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…In this work, we reported the structure-based design of triazolo­[1,5-<i>a</i>]­pyrimidines as new ABCB1 modulators, of which <b>WS-691</b> significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC₅₀ = 22.02 nM). …”

DataSheet_2_Immunotherapeutic Effects of Different Doses of Mycobacterium tuberculosis ag85a/b DNA Vaccine Delivered by Electroporation.pdf by Yan Liang (139654)

“…</p>Methods<p>Ninety-six female BALB/c mice were challenged with 2×10⁴ colony-forming units (CFUs) of MTB H₃₇Rv through tail vein injection, then was treated with 10μg, 50μg, 100μg, and 200μg of Mycobacterium tuberculosis (MTB) ag85a/b chimeric DNA vaccine delivered by intramuscular injection (IM) and electroporation (EP), respectively. …”

DataSheet_1_Immunotherapeutic Effects of Different Doses of Mycobacterium tuberculosis ag85a/b DNA Vaccine Delivered by Electroporation.pdf by Yan Liang (139654)

“…</p>Methods<p>Ninety-six female BALB/c mice were challenged with 2×10⁴ colony-forming units (CFUs) of MTB H₃₇Rv through tail vein injection, then was treated with 10μg, 50μg, 100μg, and 200μg of Mycobacterium tuberculosis (MTB) ag85a/b chimeric DNA vaccine delivered by intramuscular injection (IM) and electroporation (EP), respectively. …”

N⁶-methyladenosine-dependent primary microRNA-126 processing activated PI3K-AKT-mTOR pathway drove the development of pulmonary fibrosis induced by nanoscale carbon blac... by Bin Han (45760)

“…After CB treatment, PI3K-AKT-mTOR pathway was activated and regulated by miRNA-126. We found that both of m⁶A modifications of pri-miRNA-126 and its binding with DGCR8 were decreased after CB treatment, which resulted in the reduction of mature miRNA-126 accompanied by accumulation of unprocessed pri-miRNA-126. …”

A Novel Splice-Site Mutation in Angiotensin I-Converting Enzyme (ACE) Gene, c.3691+1G>A (IVS25+1G>A), Causes a Dramatic Increase in Circulating ACE through Deletion of the Transmem... by Alexandre Persu (396983)

“…The levels of renin-angiotensin-aldosterone system components in the mutated cases and wild-type controls were similar, both at baseline and after 50 mg captopril. Compared with non-affected members, quantification of ACE surface expression and shedding using flow cytometry assay of dendritic cells derived from peripheral blood monocytes of affected members, demonstrated a 50% decrease and 3-fold increase, respectively. …”

DCP-LA treatment of SN56 cells diverts APP into early endosome compartments. by Joshua H. K. Tam (836784)

Mutational landscape of TCL cell lines. by Rufino Mondejar (4025846)

Effectiveness of community-based complementary food supplement (Yingyangbao) distribution in children aged 6-23 months in poor areas in China by Jie Wang (16762)

“…Compared with the baseline situation (n = 823), the proportion of children fed a diverse diet and foods rich in iron or vitamin A increased (<i>P</i> < 0.01) in the follow-up study. …”

DataSheet_1_A20 Establishes Negative Feedback With TRAF6/NF-κB and Attenuates Early Brain Injury After Experimental Subarachnoid Hemorrhage.zip by Hong-Ji Deng (11182902)

“…<p>Nuclear factor (NF)-κB–ty -50mediated neuroinflammation plays a crucial role in early brain injury (EBI) after subarachnoid hemorrhage (SAH). …”

Difficulty as a function of the level. by Federico Zimmerman (3607586)

GO annotation analyses of DEGs. by Benzun Wei (21485639)

Image_1_Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota.tiff by Tejpal Gill (618904)

Image_2_Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota.tiff by Tejpal Gill (618904)

Tyrosine motif mutations affect on APP/AP-3 interaction. by Joshua H. K. Tam (836784)

⁶⁸Ga-Labeled TMTP1 Derivatives with Moderate Hydrophilicity for Positron Emission Tomography of Hepatocellular Carcinoma in High Contrast by Xiaowei Fan (10198883)

“…Subnanomolar and nanomolar affinities comparable to the non-PEGylated TMTP1 derivative were revealed by the IC₅₀ values in SMMC-7721 cells. [⁶⁸Ga]Ga-NOTA-PEG₂-TMTP1 presented a significantly higher tumor/liver ratio (4.19 ± 0.54, at 30 min post intravenous injection) and tumor/muscle ratio (2.14 ± 0.17) compared to the others and the previously radiolabeled TMTP1 derivatives. …”

Effect of fenretinide and its metabolites on SCD expression and activity. by Eugenia Poliakov (116500)

“…<p>A) SCD1 protein expression is decreased after treatment with fenretinide, and its metabolite 3-keto-HPR. …”