Presentation_1_Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis.PPTX by Wan-Chun Li (450324)

“…Loss of HK2 in HNSCC cells resulted in reduced cell (in vitro) and tumor (in vivo) growth, as well as decreased epithelial-mesenchymal transition–mediated cell movement; in contrast, HK2-deficient HNSCC cells exhibited greater sensitivity to chemotherapeutic drugs cisplatin and 5-fluorouracil but are more resistant to photodynamic therapy, indicating that HK2 expression could selectively define treatment sensitivity in HNSCC cells. …”

Presentation_1_Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis.PPTX by Wan-Chun Li (450324)

“…Loss of HK2 in HNSCC cells resulted in reduced cell (in vitro) and tumor (in vivo) growth, as well as decreased epithelial-mesenchymal transition–mediated cell movement; in contrast, HK2-deficient HNSCC cells exhibited greater sensitivity to chemotherapeutic drugs cisplatin and 5-fluorouracil but are more resistant to photodynamic therapy, indicating that HK2 expression could selectively define treatment sensitivity in HNSCC cells. …”

Table_2_Biochemical basis for the formation of organ-specific volatile blends in mint.xlsx by B. Markus Lange (2048524)

Synthesis and Activity of Ruthenium Olefin Metathesis Catalysts Coordinated with Thiazol-2-ylidene Ligands by Georgios C. Vougioukalakis (2290621)

“…A new family of ruthenium-based olefin metathesis catalysts bearing a series of thiazole-2-ylidene ligands has been prepared. These complexes are readily accessible in one step from commercially available (PCy₃)₂Cl₂RuCHPh or (PCy₃)Cl₂RuCH(<i>o</i>-<i>i</i>PrO−Ph) and have been fully characterized. …”

Synthesis and Activity of Ruthenium Olefin Metathesis Catalysts Coordinated with Thiazol-2-ylidene Ligands by Georgios C. Vougioukalakis (2290621)

“…A new family of ruthenium-based olefin metathesis catalysts bearing a series of thiazole-2-ylidene ligands has been prepared. These complexes are readily accessible in one step from commercially available (PCy₃)₂Cl₂RuCHPh or (PCy₃)Cl₂RuCH(<i>o</i>-<i>i</i>PrO−Ph) and have been fully characterized. …”

Table_4_Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis.xlsx by Wan-Chun Li (450324)

“…Loss of HK2 in HNSCC cells resulted in reduced cell (in vitro) and tumor (in vivo) growth, as well as decreased epithelial-mesenchymal transition–mediated cell movement; in contrast, HK2-deficient HNSCC cells exhibited greater sensitivity to chemotherapeutic drugs cisplatin and 5-fluorouracil but are more resistant to photodynamic therapy, indicating that HK2 expression could selectively define treatment sensitivity in HNSCC cells. …”

Synthesis and Activity of Ruthenium Olefin Metathesis Catalysts Coordinated with Thiazol-2-ylidene Ligands by Georgios C. Vougioukalakis (2290621)

“…A new family of ruthenium-based olefin metathesis catalysts bearing a series of thiazole-2-ylidene ligands has been prepared. These complexes are readily accessible in one step from commercially available (PCy₃)₂Cl₂RuCHPh or (PCy₃)Cl₂RuCH(<i>o</i>-<i>i</i>PrO−Ph) and have been fully characterized. …”

Organic Reaction as a Stimulus for Polymer Phase Separation by Masami Naya (4339054)

Specificity of 1xSPS₁₅, 2xCSL₁₇ and 2xCSL₁₇mut probes as unlabeled competitors for Su(H). by Yi Kuang (1873354)

“…<p>EMSA data reveals that the addition of the unlabeled 1xSPS₁₅ and 2xCSL₁₇ probes, but not the 2xCSL₁₇mut probe results in decreased Su(H) binding to the labeled 2xCSL₁₇ probe. 3.5nM labeled probe and 40nM Su(H) was used in indicated lanes. …”

Targeting hTERT Promoter G‑Quadruplex DNA Structures with Small-Molecule Ligand to Downregulate hTERT Expression for Triple-Negative Breast Cancer Therapy by Wei Long (411482)

“…Human telomerase reverse transcriptase (hTERT) may have noncanonical functions in transcriptional regulation and metabolic reprogramming in cancer cells, but it is a challenging target. We thus developed small-molecule ligands targeting hTERT promoter G-quadruplex DNA structures (hTERT G4) to downregulate hTERT expression. …”

Developmental patterns of expression of tectal EphA3 and retinal ephrin-As and Tyr-602 phosphorylated-EphA4. by Ana Laura Ortalli (159899)

“…The expression of ephrin-A2 extends along all the retina, presenting a decreasing naso-temporal gradient mainly in the RGCs. …”

Exploration of 2‑((Pyridin-4-ylmethyl)­amino)­nicotinamide Derivatives as Potent Reversal Agents against P‑Glycoprotein-Mediated Multidrug Resistance by Qianqian Qiu (3859564)

“…In-depth studies demonstrated <b>9n</b> has high potency (EC₅₀ = 119.6 ± 6.9 nM), low cytotoxicity, and long duration (>24 h) in reversing adriamycin (ADM) resistance in K562/A02 cells. …”

Wind speed box plots at observation stations (red) and ERA5 cells (green) at heights of 10m and 100m, respectively. by Weidong Ji (129916)

A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells by V Bhattacharjee (681247)

“…A sublethal dose (50 nM) of the drug was used to model situations of limiting drug availability to PCa tumors in vivo. …”

High-performance thin-layer chromatogram of mouse brain ganglioside distribution in control (Ctl 1, Ctl 2) and experimental (VCS, #8566, #8568) brain tissue. by Jay S. Schneider (671374)

“…Note the increase in GM1 in VCS animals and decreased GD1a, GT1a, GT1b, and GQ1b, in striatal (CD) and hippocampus (HP) samples.…”

Baseline characteristics of the study subjects^a. by Ga Young Lee (1809919)

Polysome-associated cellular mRNAs are longer and more AU-rich. by William J. Neidermyer Jr. (6866672)

“…<p>(A) Analysis of cellular mRNAs with high cytoplasmic abundance (purple) or low cytoplasmic abundance (orange) as compared to mRNAs with cytoplasmic abundance within 2 standard deviations of the mean abundance (gray) in uninfected cells. …”

Gally performs lateral transduction of over 200 kb of adjacent chromosomal DNA, including Perceval. by Pauline Misson (14559971)

“…Red bars indicate 40.1 kb steps of decreasing coverage from the <i>pac</i> site of Gally prophage, which could correspond to DNA packaged by a headful mechanism. …”

Photomicrographs of DG from control gerbils and during and after infection with <i>Giardia</i>. by Angélica González Maciel (18946369)

Visualization of a classified 3D volume. by Amrita Das Gupta (17364749)