Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Elasticity values for variables for a simulated population of female fishers. by Roger A. Powell (21222116)

Image1_Phytochemical and toxicological evaluation of Zephyranthes citrina.JPEG by Muhammad Haseeb Ur Rehman (13848379)

“…Uric acid was raised at a dose of 100 mg/kg. In acute toxicity, at 2000 mg/kg, creatinine and uric acid increased while urea levels decreased. …”

Temporal evolution of photophobic responses. by Kazunari Ozasa (1959577)

Table_2_A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation.xlsx by Ermeng Xiong (11176635)

“…Hdac1 knock-out led to strongly perturbed protein expression of antagonistic transcription factors that govern plasma cell versus B cell identity (by decreasing IRF4 and BLIMP1 and increasing BACH2 and PAX5).…”

Alpha rhythm cluster. by Eduardo Ekman Schenberg (801650)

“…B) Post-hoc analysis revealed decreases in the cluster depicted at left to be significant after 50 minutes from ingestion of ayahuasca (*p<0.05, corrected). …”

Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach by P., Sneha

“…Missense mutations of the HNF1A were retrieved from public databases and subjected to a three-step computational mutational analysis to identify the underlying mechanism. …”
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Pooling observations. by Stijn Bruneel (8113409)

Combined Serum Biomarkers in Non-Invasive Diagnosis of Non-Alcoholic Steatohepatitis by Mei Yang (51996)

“…</p><p>Results</p><p>Serum levels of CK-18-M30, FGF-21, IL-1Ra and PEDF increased, while OPG decreased in a stepwise fashion in controls, non-NASH NAFLD patients and NASH patients (<i>P</i> < 0.01). …”

Fig 6 - by Xiu-Qi Chen (13832389)

(A) Soil bin experiment site; (B) Air cannon cracking effect^‌‌. by Xia Li (14984)

Effects of riluzole on <i>I_NaP</i> and <i>I_NaT</i> in A-type neurons of the compressed DRG. by Rou-Gang Xie (179362)

“…<p>(A) Traces of <i>I_NaP</i> (bottom) induced by increasing applied voltage (top) in a compressed DRG neuron in the absence (control) and presence of riluzole (2, 10, 50 µM). …”

Fig 2 - by Mengnan Lu (12128694)

Code to generate Figure 3 from KDM1A paper by Jessica Chong (474458)

“…Additionally, as the specificity of the phenotype of interest increases, the proportion of individuals tested who have the phenotype (y-axis) naturally decreases, also resulting in increased power. A small decrease (60% to 50%) in the proportion of individuals who have the phenotype of interest can increase power more than sequencing 10,000 additional trios.…”

EdU⁺/CC-1⁺ cells are present to at least 3 months post-TBI. by Krista A. Dent (709531)

Correlation between protein abundances and R_5-20 z-score among cases at baseline. Protein abundances, normalized to mean 0 and variance 1, are displayed on the y-axis. (... by Spela Kokelj (8356644)