Showing 6,721 - 6,740 results of 30,319 for search '(( 2 step decrease ) OR ( 50 ((((we decrease) OR (nn decrease))) OR (a decrease)) ))', query time: 0.88s Refine Results
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    Shape-Based Reprofiling of FDA-Approved Drugs for the H<sub>1</sub> Histamine Receptor by Sridhar R. Vasudevan (589877)

    Published 2012
    “…Reprofiling of existing drugs to treat conditions not originally targeted is an attractive means of addressing the problem of a decreasing stream of approved drugs. To determine if 3D shape similarity can be used to rationalize an otherwise serendipitous process, we employed 3D shape-based virtual screening to reprofile existing FDA-approved drugs. …”
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    Reduction in skeletal muscle fibrosis of spontaneously hypertensive rats after laceration by microRNA targeting angiotensin II receptor by Roberta Sessa Stilhano (328847)

    Published 2017
    “…Lv-mirAT1 treatment decreased <i>At1</i> gene expression in 50% and reduced fibrosis to 7% 30 days after. …”
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    Image_2_Characterization of the Signaling Modalities of Prostaglandin E2 Receptors EP2 and EP4 Reveals Crosstalk and a Role for Microtubules.pdf by Ward Vleeshouwers (10133363)

    Published 2021
    “…Here, we employed quantitative imaging methods to characterize the early EP2 and EP4 signaling events in myeloid cells and their contribution to the dissolution of adhesion structures called podosomes, which is a first and essential step in DC maturation. …”