Combinatorial Synthesis and in Vitro Evaluation of a Biaryl Hydroxyketone Library as Antivirulence Agents against MRSA by Guanping Yu (1345770)

“…An acylation bond-forming process afforded resorcinols (<b>1</b>) and aryloxy acetonitriles (<b>2</b>) as synthons. A Lewis-acid-activated Friedel–Crafts’ acylation step involving a nitrile functionality of <b>2</b> by ZnCl₂, followed by nucleophilic attack by <b>1</b> was executed to obtain biaryl hydroxyketones in excellent yields. …”

Combinatorial Synthesis and in Vitro Evaluation of a Biaryl Hydroxyketone Library as Antivirulence Agents against MRSA by Guanping Yu (1345770)

“…An acylation bond-forming process afforded resorcinols (<b>1</b>) and aryloxy acetonitriles (<b>2</b>) as synthons. A Lewis-acid-activated Friedel–Crafts’ acylation step involving a nitrile functionality of <b>2</b> by ZnCl₂, followed by nucleophilic attack by <b>1</b> was executed to obtain biaryl hydroxyketones in excellent yields. …”

Right Atrial Deformation Analysis in Cardiac Amyloidosis - Results from the Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Path Study by Attila Nemes (730521)

Quantitative comparison of protein expression between two <i>P</i>. <i>vivax</i> salivary gland sporozoite field isolates. by Kristian E. Swearingen (2301094)

“…The population of log-transformed protein ratios of proteins detected in both samples assumed a Gaussian distribution with a mean near zero. …”

Adverse effect of ND251 aggregates on neurite outgrowth. by Huei-Ying Li (210957)

“…Cells expressing ND251S5A had a further decrease in the percentage of neurite-bearing cells in comparison with ND251. …”

Shapley Additive Explanations (SHAP) summary plot. by Yue Lv (549862)

Efficacy of dexamethasone and ACTH in drug resistant pediatric epilepsy. by Nicola Marchi (4967)

“…(<b>B</b>) Mosaic plot showing the correlation between etiology of epilepsy and likelihood of a response ≥50%. Note that etiology did not always predict response. …”

Characterization of gemcitabine-resistant subclones. by Fredrik I. Thege (12646919)

“…E-cadherin enrichment at cell-cell junctions was determined by calculating the ratio of the mean E-cadherin intensity proximal to the cellular edge and the mean E-cadherin intensity in the rest of the cell using CellProfiler, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0267882#pone.0267882.s002" target="_blank">S2 Fig</a> for analysis pipeline. …”

Image_6_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”

Image_4_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”

Image_1_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”

Image_5_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”

Image_2_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”

Image_3_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”

Deconvolution of Kombucha Tea facilitates the creation of fermenting and non-fermenting mixes of KTM. by Rachel N. DuMez-Kornegay (18271479)

“…(C) Oil Red O staining of day 1 adult animals fed an <i>E</i>. <i>coli</i> OP50, KTM-Mix, or KTMs diet, as well as a 5X concentrated version of the KTM diet (mean ± SD, ****, <i>P</i><0.0001, one-way ANOVA). …”

AZ2.0 Scripts & Code by Binay Panda (768771)

“…The updated genome assembly (v2.0) yielded 3- and 3.5-fold increase in N50 and N75, respectively; 2.6-fold decrease in the total number of scaffolds; 1.25-fold increase in the number of valid transcriptome alignments; 13.4-fold less mis-assembly and 1.85-fold increase in the percentage repeat, over the earlier assembly (v1.0). …”

Altered Heart Rates Precede Death. by David S. Auerbach (470466)

“…<p>A. DS mice exhibit significant QT prolongation (50 - 90%). …”

Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia-1 by John K Neubert (30743)

“…Animals pretreated with vehicle (0.25% Tween-80, PBS 50 μl, N = 10) had a significant decrease in their heat withdrawal latency (P < 0.05, 1 way RM-ANOVA) following induction of inflammation.…”

Behavioral stress fails to delay surgical castration-induced involution and apoptosis in mice prostates. by Sazzad Hassan (454373)

“…<p><b>A)</b> Castration-induced prostate involution. …”

Watermelon cultivation in the semi-arid irrigated with different heights of treated domestic sewage by Vinicius Couto Salgado (5668235)

“…We observed an increase in the cation exchange capacity and a decrease of the soil pH in all the treatments. …”