Showing 1,061 - 1,080 results of 30,505 for search '(( 2 step decrease ) OR ( 50 ((teer decrease) OR (((nn decrease) OR (a decrease)))) ))', query time: 0.91s Refine Results
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    Isoindolin-1-ones Fused to Barbiturates: From Design and Molecular Docking to Synthesis and Urease Inhibitory Evaluation by Houman Kazemzadeh (12742141)

    Published 2022
    “…The synthesis route consisted of two steps. These steps increased the yield rate and decreased the percentage of byproducts while approaching green chemistry using ethanol and water as green solvents and microwave irradiation instead of conventional methods. …”
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    Image2_PKA inhibition is a central step in D,L-methadone-induced ER Ca2+ release and subsequent apoptosis in acute lymphoblastic leukemia.JPEG by Hamza Kamran (18433152)

    Published 2024
    “…This is consistent with the decrease in PKA-dependent (i) inhibitory PLCβ3 Ser1105 phosphorylation that leads to PLCβ3 activation and ER Ca<sup>2+</sup> release, and (ii) BAD Ser118 phosphorylation, which together ultimately result in caspase activation and apoptosis. …”
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    Decreased Striatal RGS2 Expression Is Neuroprotective in Huntington's Disease (HD) and Exemplifies a Compensatory Aspect of HD-Induced Gene Regulation by Tamara Seredenina (213942)

    Published 2011
    “…</p> <h3>Methodology/Principal Findings</h3><p>We used protein-encoding and shRNA-expressing lentiviral vectors to evaluate the effects of RGS2, RASD2, STEP and NNAT downregulation in HD. Of these four genes, only RGS2 and RASD2 modified mutant htt fragment toxicity in cultured rat primary striatal neurons. …”
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    An Analysis of Porphyrin Molecular FlexibilityUse of Porphyrin Diacids by Beisong Cheng (2970567)

    Published 1997
    “…Molecular mechanics calculations, using a modified version of MM2(87) and a newly developed force field for porphyrin diacids, correctly predict that the flexibility of <i>meso</i>-tetraaryl porphyrin diacids decreases as the steric bulk of the peripheral substituents increases:  [H<sub>4</sub>TPyP]<sup>2+</sup> ≈ [H<sub>4</sub>TPP]<sup>2+</sup> > [H<sub>4</sub>T-2,6-(OH)<sub>2</sub> PP]<sup>2+</sup> ≈ [H<sub>4</sub>T-2,6-F<sub>2</sub> PP]<sup>2+</sup> > [H<sub>4</sub>T-2,6-Cl<sub>2</sub> PP]<sup>2+</sup> ≈ [H<sub>4</sub>TMP]<sup>2+</sup>. …”
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