Effect of CA-Inhibitors on sperm beat frequency and CA-activity. by Petra M. Wandernoth (149629)

“…The addition of varying EZA concentrations results in a decrease of enzymatic activity of between 35.0% (4.53±0.87 U/ml) for 50 nM EZA and 62.12% (2.72±0.12 U/ml) for 5 µM EZA (<i>n</i> = 6). …”

Data_Sheet_1_Long-Term Prognosis of Cognitive Function in Patients With Idiopathic Normal Pressure Hydrocephalus After Shunt Surgery.xlsx by Akihiro Kambara (10006775)

“…The patients were classified in to the cognitive decline group [11 (23%) patients; a decrease in the MMSE score by ≥ 2 points 2 years after surgery] and the maintenance/improvement group [37 (77%) patients]. …”

Phylodynamics and Dispersal of HRSV Entails Its Permanence in the General Population in between Yearly Outbreaks in Children by Hagit Katzov-Eckert (127635)

“…</p> <h3>Methodology/Principal Findings</h3><p>Here through a comprehensive analysis of the two major HRSV groups A and B (n = 1983) which comprise of several genotypes, we present a complex pattern of population dynamics of HRSV over a time period of 50 years (1956–2006). …”

Antigenic evolution of viruses in host populations by Igor M. Rouzine (525036)

“…The fitness slope (effective selection coefficient) is proportional to the reproductive number in the absence of immunity <i>R</i>₀ and inversely proportional to the cross-immunity distance <i>a</i>, defined as the genetic distance of a virus strain from a previously infecting strain conferring 50% decrease in infection probability. …”

DNMT3L was found within the adult testis and mature sperm. by Natasha M. Zamudio (225855)

“…Results are presented as means ± SEM. <b>*</b> Indicates a statistically significant decrease in relative intensity of DNMT3L with a p≤0.05.…”

DataSheet1_Restoring Nature at Lower Food Production Costs.docx by Yiorgos Vittis (10870491)

“…Although production inputs per unit of output increase at local scales, a reduction of cultivated land of 50% overcompensates the slightly higher field-scale costs enabling improved overall cost-effectiveness. …”

Metformin does not further increase the median lifespan of DR-constitutive mutant eat-2, and metformin treatment triggers several DR phenotypes in wild-type <i>C. elegans</i> witho... by Brian Onken (86790)

“…We performed this experiment a total of four times, with two of the trials showing significantly different survival curves for the 10 mM and 50 mM groups. …”

Supplementary Material for: Time of delivery contributes to mortality and morbidity in preterm infants by Teivaanmäki T. (17006268)

“…Methods We explored the time and mode of birth of infants with birthweight of <1500g and gestational age of <32+0/7 weeks. …”

Increases in turbidity reduce territory defense and exploration in an East African cichlid (<i>Neolamprologus pulcher</i>) by Markus Zöttl (10309796)

“…Half of all subjects underwent the treatment first and one day later the control whereas in the other half, we reversed this order. To measure turbidity, we collected water samples in 50 mL falcon tubes for each individual before each behavioural assay and measured turbidity with a WTW Lab Turbidity Meter Turb 550 IR.…”

Scutellarin’s Cardiovascular Endothelium Protective Mechanism: Important Role of PKG-I<i>α</i> by Lin Li (28817)

“…The activation of PKG–1α was then studied using targeted proteomic analysis (MRM-MS) checking the phosphorylation state of the autophosphorylation domain (aa42-94). Significant decrease in phosphorylation of PKG-Iα at Ser50, Ser72, Ser89 was induced by HR injury while SCU treatment significantly increased the phosphorylation of PKG-Iα, not only at Ser50, Ser72 and Ser89, but also at Ser44 and Thr58 (two novel phosphorylation domains). …”

Mitochondrial superoxide governs cell number. by Tejas M. Gupte (743674)

“…(the depletion of mitofusin alone) to 5.4 x 10⁸ ± 0.7 x 10⁸. Values are mean ± SD from a three experiments with 50 cells per genotype.…”

Expression of Lyn^WT and Lyn^Y397F in 663 cells. by Olivier Kosmider (372523)

Ethnic inequality impacts after 10 years from two sodium reduction interventions (CVD mortality rates, rate ratios and rate differences, and QALYs gained for individuals given mode... by Nhung Nghiem (112428)

Cost-utility analysis of de-escalating biological disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis by Benjamin Birkner (8212203)

“…We compared continuing treatment (standard care) to a tapering approach (i.e., an immediate 50% dose reduction), withdrawal (i.e., an immediate 100% dose reduction) and tapering followed by withdrawal of bDMARDs. …”

Galectin-3 Functions as an Alarmin: Pathogenic Role for Sepsis Development in Murine Respiratory Tularemia by Bibhuti B. Mishra (392001)

“…<div><p>Sepsis is a complex immune disorder with a mortality rate of 20–50% and currently has no therapeutic interventions. …”

Distinct Populations of Hepatic Stellate Cells in the Mouse Liver Have Different Capacities for Retinoid and Lipid Storage by Diana N. D'Ambrosio (204864)

“…<div><p>Hepatic stellate cell (HSC) lipid droplets are specialized organelles for the storage of retinoid, accounting for 50–60% of all retinoid present in the body. When HSCs activate, retinyl ester levels progressively decrease and the lipid droplets are lost. …”

Comparison of the Simulated Activities of PI3K, Membrane-Bound PTEN, and the Resulting Behavior of PIP₃ (Composite Screenshot) by Martin Meier-Schellersheim (63389)

“…<p>Stimulation of a cell in a 2:1 cAMP gradient (mean concentration 500 nmol) leads to a rapid 3-fold increase in the membrane proximal activity of PI3K (green) and to a loss of membrane-bound PTEN (blue; tracked as GFP-PTEN in real cells). …”

Effects of adenosine receptor-specific antagonists on responses to hypoxia at E9.5 and E12.5. by Daniela L. Buscariollo (140729)

“…At both ages, heart rates were not affected by SCH-58261 treatment (A and B). In contrast, at both ages DPCPX elevated heart rates above vehicle levels in normoxic conditions and inhibited hypoxia-mediated heart rate decrease below baseline (A and B). …”

Transmembrane signaling in cell-derived plasma membrane vesicles. by Luigino Grasso (208932)

“…(D) The FRET signal increases with the concentration of agonist APEC added to the bulk solution (concentrations indicated above the bars in nM). (E) A dose-dependent increase of the FRET yields <i>EC₅₀</i> = 100±11 nM; shown are averages and standard deviations of the mean of nine titration experiments each performed on different, individual vesicles.…”

Implications of high species turnover on the south-western Australian sandplains by Neil Gibson (3272331)

“…This high replacement rate, well documented in the mega-diverse south-west, appears to also be a consistent feature of arid zone vegetation systems despite a decrease in overall species richness. …”