Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

A Minor (<50%) Signet-Ring Cell Component Associated with Poor Prognosis in Colorectal Cancer Patients: A 26-Year Retrospective Study in China by Yinuo Tan (705777)

“…<div><p>Background</p><p>We performed a retrospective study to determine the cancer-specific survival of colorectal cancer patients with a component of signet-ring cells or mucin comprising < 50% of the tumor mass.…”

The minimum inhibitory concentrations (µg/mL) and the minimum bactericidal concentrations (µg/mL) of synthesized 1,2,3,5-tetrazine derivatives. by Jean Paul Dzoyem (6424445)

Subjects:

Percentages of inhibition of biofilm formation and eradication of synthesized 1,2,3,5-tetrazine derivatives. by Jean Paul Dzoyem (6424445)

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Reactions’ sequences to compounds 4. by Jean Paul Dzoyem (6424445)

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Percentage of violacein production in <i>Chromobacterium violaceum</i> by the most active synthesized 1,2,3,5-tetrazine derivatives (4a, 4b and 4c). by Jean Paul Dzoyem (6424445)

Subjects:

Image_1_Decreased MEF2A Expression Regulated by Its Enhancer Methylation Inhibits Autophagy and May Play an Important Role in the Progression of Alzheimer’s Disease.TIF by Hui Li (32376)

The S75A mutation of LeishIF4E3 leads to a decrease in granule formation in response to PBS starvation and to a reduced interaction with LeishIF4G-4. by Rohit Shrivastava (6459608)

Anti-cancer stem cell activity of a sesquiterpene lactone isolated from <i>Ambrosia arborescens</i> and of a synthetic derivative by Wendy Soria Sotillo (4408105)

“…<div><p>New regimens are constantly being pursued in cancer treatment, especially in the context of treatment-resistant cancer stem cells (CSCs) that are assumed to be involved in cancer recurrence. Here, we investigated the anti-cancer activity of sesquiterpene lactones (SLs) isolated from <i>Ambrosia arborescens</i> and of synthetic derivatives in breast cancer cell lines, with a specific focus on activity against CSCs. …”

Presentation_1_Do We Overestimate the Within-Variability? The Impact of Measurement Error on Intraclass Coefficient Estimation.pdf by Rafael Wilms (8858795)

A heat map was generated for all the miRs utilized in the array, as a function of a fold change from referent control values. by Stephanie L. Samani (17896610)

Root cell wall proteins with significant decreased in expression level under 50 µM Cu treatment identified by LC-ESI-MS/MS-based proteomics using SIEVE (<i>p</i><0.05 and fold chan... by Tingting Liu (267387)

“…</p><p>Root cell wall proteins with significant decreased in expression level under 50 µM Cu treatment identified by LC-ESI-MS/MS-based proteomics using SIEVE (<i>p</i><0.05 and fold chang >1.5).…”

Inner sphere oxidation of N,N′-ethylenebis(isonitrosoacetyleacetoneimine)copper(II) by N-bromosuccinimide in aqueous weakly acidic solutions by Salih, Isam M.

“…The mechanism of the title reaction is consistent with an inner sphere mechanism in which a pre-equilibrium step precedes the electron transfer step. The overall rate law is represented by Eq. (2) where [CuIL]t and K 1 represent the total copper(II) complex concentration and the pre- equilibrium formation constant, respectively. d [CuL+]/dt = {(ko+k₁ [H+]) [SBr] [CuL]}/(1 + K₁ [SBr])…”
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IFNγ increases PRL immunoreactivity in the hair follicle, whilst TNFα decreases follicular PRL immunoreactivity. by Ewan A. Langan (405804)

“…<p>(A) PRL IR in control hair follicle outer root sheath keratinocytes (black arrows), (B) after INFγ treatment and (C) negative control. …”

A) Exemplary relative quantification of AUREO1a concentration in protein extracts of <i>P. tricornutum</i> WT, <i>aureo1a-15</i> and <i>aureo1a-50</i> by an immunoblot using an ant... by Benjamin Schellenberger Costa (461158)

Proteins in thyroid tissue with differential expression levels above or below 1.5 for all activity groups (0.5, 5, 50 and 500 kBq) (totally 133 proteins). by Malin Larsson (1616557)

Infections per activity type. by Sebastian A. Müller (10688740)