Activity of the small molecule PLK1, 2, and 3 inhibitor BI 2536 in preclinical models of MM in the absence of the bone microenvironment. by Douglas W. McMillin (348456)

“…<p>(A) BI 2536 (0–80 nM; 72 hrs) was tested against a panel of MM cell lines by MTT assay, the majority having IC50 values <40 nM. …”

N-Way FRET on the excitation-emission landscape. by Adam D. Hoppe (280794)

“…Linear unmixing with <b>B</b> to allows estimation of concentrations of total fluorophores ([CFP] and [YFP]) and apparent FRET (E_CY[CFP-YFP]) which are contained in vector <b>c</b>. During this step, a negative component (blue color) couples the FRET-associated decrease in donor fluorescence to an increase in acceptor fluorescence. …”

DSS-induced colitis mouse model. by William C. Reisdorf (6616148)

“…Experimental groups were: Sham = vehicle control (no DSS or other treatment, n = 6), DSS = DSS-only (n = 12), CsA = 10 mg/kg i.p. treatment (n = 6), EPHX2i = GSK1910364A 50 mg/kg orally, twice daily (n = 6). …”

Chemical Force Spectroscopy Evidence Supporting the Layer-by-Layer Model of Organic Matter Binding to Iron (oxy)Hydroxide Mineral Surfaces by Alexander W. Chassé (1664638)

“…Increasing molecular mass was shown to decrease the adhesion force between the mineral surface and the DOM. …”

Effect of age group and TBI on change in muscle thickness in critically-ill children. by Ryan W. Johnson (6103013)

“…To account for multiple comparisons, discovery (q) was determined using the two-stage linear step-up procedure of Benjamini, Krieger and Yekuteli (BKY) with FDR = 10%; *q = 0.061, **q = 0.028, ***q = 0.005. …”

Intense reelin IR neurons synthesize reelin whereas punctate reelin IR neurons are characterized by the presence of receptor-bound reelin. by Cecilia Gonzalez Campo (264260)

“…GST-RAP was used at 25, 40 and 50 µg/ml. A significant decrease of punctate reelin IR was observed with 40 and 50 µg/ml of GST-RAP (4.5±1.5% and 3.1±0.7%; n = 3 and 3) whereas no effect was detected with a concentration of 25 µg/ml compared to untreated (22.2±1.4% and 21.3±2.2%; n = 3 and 3; F_(3,8) = 45.7, ***P<0.001). …”

Clinical and virological profiles of D9 vaccine trial group. by Jodi K. Craigo (421284)

“…<p>(<b>A</b>) Eight EIAV-naïve ponies were vaccinated with 3×10³ TCID₅₀ D9 I.M. …”

Video_1_Pak1 Kinase Promotes Activated T Cell Trafficking by Regulating the Expression of L-Selectin and CCR7.AVI by Ana Dios-Esponera (6422411)

“…Lymphocyte homing to lymph nodes requires that they cross endothelial barriers present in blood vessels and lymphatics. This multi-step process requires a remodeling of the lymphocyte plasma membrane, which is mediated by the dynamic re-arrangement of the actin cytoskeleton. …”

Video_3_Pak1 Kinase Promotes Activated T Cell Trafficking by Regulating the Expression of L-Selectin and CCR7.AVI by Ana Dios-Esponera (6422411)

“…Lymphocyte homing to lymph nodes requires that they cross endothelial barriers present in blood vessels and lymphatics. This multi-step process requires a remodeling of the lymphocyte plasma membrane, which is mediated by the dynamic re-arrangement of the actin cytoskeleton. …”

Data_Sheet_1_Pak1 Kinase Promotes Activated T Cell Trafficking by Regulating the Expression of L-Selectin and CCR7.docx by Ana Dios-Esponera (6422411)

“…Lymphocyte homing to lymph nodes requires that they cross endothelial barriers present in blood vessels and lymphatics. This multi-step process requires a remodeling of the lymphocyte plasma membrane, which is mediated by the dynamic re-arrangement of the actin cytoskeleton. …”

Table1_A Mendelian randomization study for drug repurposing reveals bezafibrate and fenofibric acid as potential osteoporosis treatments.docx by Xiao-Hua Li (1508020)

“…</p><p>Methods: We conducted two-step Mendelian randomization (MR) analyses to investigate the causal association of genetically proxied lipid-lowering drugs on the risk of OP. …”

Table_1_Protective Effects of Dietary Supplements Containing Probiotics, Micronutrients, and Plant Extracts Against Lead Toxicity in Mice.DOCX by Qixiao Zhai (830803)

“…A step-through passive avoidance task confirmed that the dietary supplements could recover the learning and memory capacities of Pb-exposed mice. …”

Table_3_Protective Effects of Dietary Supplements Containing Probiotics, Micronutrients, and Plant Extracts Against Lead Toxicity in Mice.DOCX by Qixiao Zhai (830803)

“…A step-through passive avoidance task confirmed that the dietary supplements could recover the learning and memory capacities of Pb-exposed mice. …”

Effect of the lytic enzyme PeiR on M1 growth <i>in vitro</i>. by Sinead C. Leahy (244590)

Effect of anisotropy. by Diarmuid J. Cahalane (233294)

The effect of inhibition on metabolically efficient information transfer. by Tomas Barta (8067509)

Effect of aerobic exercise on intramyocellular (IMCL) and intrahepatocellular lipids (IHCL). by Andrea Egger (107540)

“…<p><b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0070865#pone-0070865-g003" target="_blank"><b>Figure 3a</b></a></b> Individual IMCL and IHCL measurements before (pre) and after (post) a 2h-aerobic exercise at 50% VO_2max of each subject. …”

Analytical vs numerical evaluation of oscillatory solutions in the Gaussian-drift approximation. by Natalie Schieferstein (17996519)

“…Including the reset does not affect <i>μ</i>_max but leads to a decrease in <i>μ</i>_min (Eqs (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1011886#pcbi.1011886.e181" target="_blank">50</a>) vs (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1011886#pcbi.1011886.e172" target="_blank">43</a>)) and thus a decrease in network frequency. …”

Data_Sheet_1_The Mental Health Ecosystem: Extending Symptom Networks With Risk and Protective Factors.docx by Gabriela Lunansky (10320749)

“…These risk and protective factors influence symptom development patterns and thereby increase or decrease the probability that the symptom network is pulled toward a healthy or disorder state. …”

Quantitative Analysis of Lipid Droplet Fusion: Inefficient Steady State Fusion but Rapid Stimulation by Chemical Fusogens by Samantha Murphy (144193)

“…LD fusion involved an initial step in which the two adjacent membranes became continuous (<10 s), followed by the slower merging (100 s) of the neutral lipid cores to produce a single spherical LD. …”