Validation of complete model with trafficking and phosphorylation parameters. by Lindsay Wendel Clegg (754229)

“…TIME cells, [V] = 50 ng/mL, measurements taken at t = 5 min. In the model, the experimentally observed decrease in VEPTP expression to 20% of control values with VEPTP siRNA was simulated by decreasing the dephosphorylation rate for Y951 and Y1175 by a factor of 5 on the cell surface. …”

Influence of <i>k</i>₁ on the homeostatic behavior of the m7 ping-pong controller when <i>E</i>₁ binds first to free enzyme <i>Ez</i>. by Qaiser Waheed (5095328)

“…(c) A decrease of <i>k</i>₆ from 5.0 to 1.0 while <i>k</i>₁ is kept at 100.0 gives a general improvement of the homeostatic performance of the ping-pong controller, except for the higher end <i>k</i>₅ range between 900–1000, where <i>A</i>_<i>ss</i> becomes constant (indicated by the red circle). …”

Wet laboratory validation of in silico results. by Patrick Baum (235495)

“…IL-6 secretion was analyzed as surrogate marker for pro-inflammatory processes. A: High content screen images of HaCaT cells treated with increasing concentrations (3.2 nM – 50 µM) of Ex1 and BI5 including DMSO (negative control) or 100 µM Valinomycin and 10 µM Chloroquine (positive control) for 24 h. …”

Inter-county mobility patterns reflect social distancing and travel restrictions. by Hengfang Deng (7003667)

“…While the data only lost a small number of devices, the two measures both plummeted more than 50% within two weeks before recovering.…”

Supplementary Material for: Polypharmacy and the Progression of Chronic Kidney Disease: Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease by Min H.K. (10922121)

“…Polypharmacy was defined as taking 6 or more medications at the time of enrollment; renal events were defined as a ≥50% decrease in kidney function from baseline values, doubling of the serum creatinine levels, or initiation of renal replacement treatment. …”

hERG Potassium Channel Blockage by Scorpion Toxin BmKKx2 Enhances Erythroid Differentiation of Human Leukemia Cells K562 by Jian Ma (170138)

“…</p> <p>Principal Findings</p><p>The hERG potassium channel blockage by a new 36-residue scorpion toxin BmKKx2, a potent hERG channel blocker with IC₅₀ of 6.7±1.7 nM, enhanced the erythroid differentiation of K562 cells. …”

KMM cells do not require glucose for proliferation, survival and formation of colonies in Softagar. by Ying Zhu (90057)

“…<p>(<b>A</b>). KMM cells do not require glucose for proliferation. …”

Alterations of sirtuins in mitochondrial cytochrome c-oxidase deficiency by Arne Björn Potthast (4529689)

“…</p><p>Results</p><p>We observed a significant decrease in cellular levels of all three sirtuins at the activity, protein and transcriptional level (by 15% to 50%) in COX-deficient cells. …”

Waist-to-Height Ratio and Cardiovascular Risk Factors among Chinese Adults in Beijing by Li Cai (3899)

“…AUCs for the relationships between anthropometric indices and the three outcomes were larger in women than in men, and tended to decrease with age. Optimal cutoffs for WHtR were 0.51–0.53 and 0.48–0.50 in men and women, respectively. …”

Table_1_Meta-Analysis of Dyslipidemia Management for the Prevention of Ischemic Stroke Recurrence in China.DOCX by Kang-Ning Chen (9659927)

“…</p><p>Conclusions: Effective lipid-lowering therapy could decrease the blood LDL-C level, which had a protective effect against stroke recurrence. …”

Insights of Zinc Ion Storage in Chilli-Stem Derived Porous Carbon Enabling Ultrastability and High Energy Density of Zinc-Ion Hybrid Supercapacitors by Himanshu Gupta (412433)

“…Simulations further reveal important atomic interactions, demonstrating that higher currents drawn from the device cause partial filling of pores and blockages in the channels and result in a decrease in the device’s specific capacity. Benefitted by CSK’s impressive performance, the aqueous Zn@pCu//CSK full-cell device has demonstrated good energy-power densities (57.7 W h/kg and 4.5 k W/kg) and durability over tens of thousands of cycles, further substantiating ZIHSCs’ application prospects in real life.…”

Effect of MTDH gene overexpression on clinical sensitivity of doxorubicin. by Zhenchuan Song (741160)

“…<b>(</b>F, G) In the MTDH transfected group, the cell cycle measured by FCM and showed a increase in the proportion of cells in the S and G2/M phase and decrease in cells in the G0/G1 phases compared to the untransfected group. …”

datasheet1_COVID-19 Incidence in Patients With Immunomediated Inflammatory Diseases: Influence of Immunosuppressant Treatments.docx by Natalia Soldevila-Domenech (9903768)

“…Our results report a decreased incidence of COVID-19 in patients receiving specific DMARDs with different immunodepressor mechanisms with striking sex differences. …”

Data_Sheet_1_Short-term effectiveness of baricitinib in children with refractory and/or severe juvenile dermatomyositis.xlsx by Zhaoling Wang (630187)

“…</p>Results<p>The skin rash improved in 95% of patients (19/20) at week 24, with a significant decrease of skin-DAS at weeks 12 (6.0 vs. 2.0, p < 0.05] and week 24 [6.0 vs. 1.0, p < 0.05) by median statistics. …”

Table_1_Longitudinal Gut Bacterial Colonization and Its Influencing Factors of Low Birth Weight Infants During the First 3 Months of Life.DOCX by Cheng Chi (655368)

“…Alpha-diversity of both groups displayed a decreasing trend followed by slight variations. …”

Planning Study of Flattening Filter Free Beams for Volumetric Modulated Arc Therapy in Squamous Cell Carcinoma of the Scalp by Youqun Lai (674895)

“…For HFQ-VMAT-FF plans, there was a significant decrease by 12.6% in the mean dose to the brain compared with HFF-VMAT-FF. …”

Effect of light wavelength on hot spring microbial mat biodiversity by Akifumi Nishida (4807494)

“…The specific activation of <i>Thermosynechococcus</i> led to increased abundance of several other bacteria, whereas wavelengths specific to <i>Chloroflexus</i> and <i>Roseiflexus</i> induced a decrease in >50% of the community members as compared to the dark conditions. …”

Protective Effects of Carbon Monoxide-Releasing Molecule-2 on the Barrier Function of Intestinal Epithelial Cells by Xinwei Mu (611008)

“…</p><p>Results</p><p>CORM-2 significantly reduced LPS-induced secretion of TNF-α and IL-1β. The LPS-induced decrease of TER and increase of permeability to FITC-dextran were inhibited by CORM-2 in a concentration dependent manner (P<0.05). …”

Supplementary Material for: Different Roles of Functional and Structural Renal Markers Measured at Discontinuation of Renal Replacement Therapy for Acute Kidney Injury by Yoshida T. (2879729)

“…Major adverse kidney events (MAKEs) were defined as death, requirement for dialysis, or a decrease in the estimated glomerular filtration rate (eGFR) of more than 25% from the baseline at day 90. …”

FOXC1 modulates MYOC secretion through regulation of the exocytic proteins RAB3GAP1, RAB3GAP2 and SNAP25 by Alexandra Rasnitsyn (4062982)

“…FOXC1 positively regulates RAB3GAP1 and RAB3GAP2, while either increase or decrease in FOXC1 levels beyond its normal range results in decreased SNAP25. …”