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761
The Interference of Notch1 target Hes1 affects cell growth, differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets
Published 2017“…Depletion of Hes1 protein induces major changes in cell morphology, cell growth rate and in the invasive ability of shHes1-CSC in response to growth factor EGF. shHes1-CSC show a decrease of the stemness marker Nestin concurrently to a marked increase of neuronal marker MAP2 compared to pLKO.1-CSC. …”
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762
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764
NADPH-derived ROS generation drives fibrosis and endothelial-to-mesenchymal transition in systemic sclerosis: Potential cross talk with circulating miRNAs
Published 2022“…Although the etiopathology of this disease is largely unknown, endothelial damage and oxidative stress appear implicated in its initiation and maintenance. Here, we show for the first time that circulating factors present in SSc sera increased reactive oxygen species (ROS) production, collagen synthesis, and proliferation of human pulmonary microvascular endothelial cells (HPMECs). …”
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Reduced Graphene Oxide Incorporated GELMA Hydrogel Promotes Angiogenesis for Wound Healing Applications
Published 2019“…Non-healing or slow healing of chronic wounds is among the serious complications of diabetes. The decrease in blood supply due to lack of angiogenesis leads to reduced supply of oxygen, nutrients and growth factors resulting in decreased proliferation and migration of endothelial cells involved in formation of blood vessels. …”
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768
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769
Global, regional, and national stillbirths at 20 weeks' gestation or longer in 204 countries and territories, 1990–2021: findings from the Global Burden of Disease Study 2021
Published 2024“…The estimated number of stillbirths occurring at 20 weeks' gestation or longer decreased from 5·08 million (95% UI 4·07–6·35) in 1990 to 3·04 million (2·61–3·62) in 2021, corresponding to a 39·8% (31·8–48·0) reduction, which lagged behind a global improvement in neonatal deaths of 45·6% (36·3–53·1) for the same period (down from 4·03 million [3·86–4·22] neonatal deaths in 1990). …”
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STRUCTURAL AND FUNCTIONAL APPROACHES TOWARD ACTIVITY RESTORATION OF NOVEL CYSTATHIONINE BETA-SYNTHASE MUTATIONS
Published 2024“…In contrast, all the other CBS mutation studies did not fully retain heme and, when compared to the wild-type enzyme, exhibited more significant impairments in both the canonical cystathionine synthesis and the alternative H2S-producing reactions. This reduced activity is consistent with both in vitro and in silico evidence, which indicates that the studied CBS mutations, except p.K72I, significantly decrease the overall protein's stability, which may represent the underlying cause of their pathogenicity. …”
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772
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773
Climatology and variability of wind speeds along the southwest coast of India derived from Climate Forecast System Reanalysis winds
Published 2022“…The study reveals significant decreasing trends in annual mean wind speeds, of the order of −2.0 to −2.5 cm·s−1·year−1, for the period 1979–2019. …”
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774
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Experimental investigation on the compressibility of Al/Al2O3 nanocomposites
Published 2016“…The results showed that the grain size of milled powders was about 43 nm with a noticeable presence of agglomerates at 10 wt.% of Al2O3. …”
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776
Investigating the utilization of healthcare services to manage respiratory tract infections (RTIs) among Qatari patients attended selected primary healthcare centers in Qatar
Published 2018“…Highest number of patients with a comorbidity of Diabetes (12.85%), followed by Hypertension (10.54%). …”
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777
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Effect of Magnetic Baffles and Magnetic Nanofluid on Thermo-Hydraulic Characteristics of Dimple Mini Channel for Thermal Energy Applications
Published 2022“…In addition, there is a decrease in the pressure drop of 10.82%, 16.778%, and 26.75% when magnetic fields of 1200 G, 1500 G, and 2000 G, respectively, are applied at x = 15 mm, as compared to flow without magnetic field when the pitch = 10 mm. …”
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