Image_3_Essential Oil Derived From Eupatorium adenophorum Spreng. Mediates Anticancer Effect by Inhibiting STAT3 and AKT Activation to Induce Apoptosis in Hepatocellular Carcinoma.... by Hao Chen (5190)

“…Mechanistically, EAEO significantly decreased the ratio of Bcl-2/Bax and resulted in the activation of caspase-9 and -3. …”

Supplementary Material for: Ketamine’s Effects on the Glutamatergic and GABAergic Systems: A Proteomics and Metabolomics Study in Mice by Weckmann K. (5977448)

“…In addition, myelin basic protein levels were analyzed by Western Blot. We found altered GABA, glutamate and glutamine metabolite levels and ratios as well as increased levels of putrescine and serine – 2 positive modulators of the NMDAR. …”

Frequencies of chromosomal inversions in <i>Drosophila melanogaster</i> in Fukushima after the nuclear power plant accident by Masanobu Itoh (4530676)

“…<div><p>In order to investigate genetic impact of a large amount of radionuclides released by the Fukushima Dai-ichi Nuclear Power Plant accident in 2011, we surveyed 2,304 haploid genomes of <i>Drosophila melanogaster</i> collected in three localities in Fukushima in 2012 and 2013 for chromosomal inversions. …”

Table 1_Analysis and validation of biomarkers and immune cell infiltration profiles in unstable coronary atherosclerotic plaques using bioinformatics and machine learning.xlsx by Pengyue Jin (11657894)

“…</p>Results<p>In conclusion, enrichment analyses demonstrate that genes are significantly enriched in inflammatory and immune-related pathways. We identified HSPA2 and GEM as key genes and validated them experimentally. …”

This figure shows the effective refractive index correction given the specific geometry of the source, crystal and detector system by C T Chantler (557430)

“…This 4.5 ppm result decreases the uncertainty over the past literature by a factor of 2.6 and is 2.4 standard deviations from the previous standard. …”

Image_6_Identification of Sorafenib as a Treatment for Type 1 Diabetes.tif by Qin Zeng (166641)

“…Mechanistically, sorafenib indirectly inhibited janus kinase 2 (JAK2) activity and blocked IL-12-induced phosphorylations of JAK2 and signal transducer and activator of transcription 4 (STAT4). …”

Supplementary Material for: Indicated Stress Prevention addressing adolescents with high stress levels based on principles of Acceptance and Commitment Therapy – a Randomized Contr... by Binder F. (17499465)

“…Via block-randomization n = 70 participants were allocated to receive ACT (n = 38) or WLC (n = 32) and subsequent ACT. We used a multimodal assessment (self-reports, interviews, ecological momentary assessment, physiological markers), before treatment (T1), after the training of the ACT-group (T2) and after subsequent training in the WLC-group (T3). …”

Image_5_Identification of Sorafenib as a Treatment for Type 1 Diabetes.tif by Qin Zeng (166641)

“…Mechanistically, sorafenib indirectly inhibited janus kinase 2 (JAK2) activity and blocked IL-12-induced phosphorylations of JAK2 and signal transducer and activator of transcription 4 (STAT4). …”

Image_3_Identification of Sorafenib as a Treatment for Type 1 Diabetes.tif by Qin Zeng (166641)

“…Mechanistically, sorafenib indirectly inhibited janus kinase 2 (JAK2) activity and blocked IL-12-induced phosphorylations of JAK2 and signal transducer and activator of transcription 4 (STAT4). …”

Noise Propagation in Gene Regulation Networks Involving Interlinked Positive and Negative Feedback Loops by Hui Zhang (7197)

“…Here, by using the signal sensitivity (susceptibility) and noise amplification to quantify noise propagation, we analyze an abstract model of the Myc/E2F/MiR-17-92 network that is composed of a coupling between the E2F/Myc positive feedback loop and the E2F/Myc/miR-17-92 negative feedback loop. …”

ATRA Inhibits the Proliferation of DU145 Prostate Cancer Cells through Reducing the Methylation Level of HOXB13 Gene by Zhiwei Liu (151279)

“…Moreover, ATRA could upregulate <em>HOXB13</em> through decreasing EZH2 and DNMT3b expressions and reducing their interactions with the <em>HOXB13</em> promoter. …”

Cohesin Is Limiting for the Suppression of DNA Damage–Induced Recombination between Homologous Chromosomes by Shay Covo (246428)

“…Unlike <em>RAD50</em> and <em>RAD51</em>, which play a direct role in HR, a 4-fold reduction in the number of essential <em>MCD1</em> sister chromatid cohesion subunit genes affected survival of gamma-irradiated G₂/M cells. The decreased survival reflected a reduction in DSB repair. …”

The ERF versus the number, <i>n</i>, of positions in the viral genome giving rise to concerning (or viable) mutations. by Gabriela Lobinska (13229443)

“…We observe that the ERF decreases as function of <i>n</i>. …”

Image1_Halofuginone inhibits tumor migration and invasion by affecting cancer-associated fibroblasts in oral squamous cell carcinoma.jpeg by Danni Wang (3953762)

“…In the orthotopic transplanted tongue carcinoma in mice model, we confirmed that HF administration inhibited tumor growth and lymph node metastasis (LNM) with reduced CAF population, MMP2 expression and collagen deposition in tumor. …”

Image_1_Essential Oil Derived From Eupatorium adenophorum Spreng. Mediates Anticancer Effect by Inhibiting STAT3 and AKT Activation to Induce Apoptosis in Hepatocellular Carcinoma.... by Hao Chen (5190)

“…Mechanistically, EAEO significantly decreased the ratio of Bcl-2/Bax and resulted in the activation of caspase-9 and -3. …”

Discovery of Novel Pyrazolo[3,4‑<i>b</i>] Pyridine Derivatives with Dual Activities of Vascular Remodeling Inhibition and Vasodilation for the Treatment of Pulmonary Arterial Hyper... by Liqing Hu (9409143)

“…Given the unique advantages of significant vascular remodeling inhibition and moderate vascular relaxation based on the dual pathway regulation, we proposed <b>2</b> as a promising lead for anti-PAH drug discovery.…”

Winter Conditions and Land Cover Structure the Subnivium, A Seasonal Refuge beneath the Snow by Sonia K. Petty (746990)

“…To explore the effects of land cover and climate change on the subnivium, we measured snow pack characteristics (depth and density), and ambient and subnivium temperatures from three different land cover types (prairie, deciduous forest, and coniferous forest) and within a micro-greenhouse (2.5 x 2.5 x 2 m) that maintained a temperature of 5°C warmer than outdoor ambient temperatures, and automatically opened during snow events throughout the winter of 2013/14. …”

Data Sheet 1_Distinct Arnica montana L. extracts modulate human T cell activation in different ways via differential inhibition of NFκB and NFAT pathways.zip by Karina M. Berschneider (14001561)

“…This could be traced back to reduced IL-2 responsiveness due to decreased CD25 (IL–2Rα chain) expression, accompanied by reduced IL-2 production. …”

Diverse Outcomes of REST Function on ESC and NSC Gene Expression Profiles by Rory Johnson (172986)

“…<div><p>(A and B) The numbers of genes decreasing (“down”) and increasing (“up”) in response to DN:REST treatment are shown (<i>p</i> < 0.01 threshold for statistical significance) for (A) NSC and (B) ESC.…”

Lesion size was significantly reduced at day 7 after laser injury in mice with sympathetic nerves blockade. by Xue Tan (2994324)

“…(C) Splenectomized mice also showed a decreased lesion size after laser injury compared with controls. …”